Breast cancer survival and season of surgery: an ecological open cohort study
Background Vitamin D has been suggested to influence the incidence and prognosis of breast cancer, and studies have found better overall survival (OS) after diagnosis for breast cancer in summer–autumn, where the vitamin D level are expected to be highest.Objective To compare the prognostic outcome...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2012-01-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/2/1/e000358.full |
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| author | Dorthe Teilum Karsten D Bjerre Anne M Tjønneland Niels Kroman |
| author_facet | Dorthe Teilum Karsten D Bjerre Anne M Tjønneland Niels Kroman |
| author_sort | Dorthe Teilum |
| collection | DOAJ |
| description | Background Vitamin D has been suggested to influence the incidence and prognosis of breast cancer, and studies have found better overall survival (OS) after diagnosis for breast cancer in summer–autumn, where the vitamin D level are expected to be highest.Objective To compare the prognostic outcome for early breast cancer patients operated at different seasons of the year.Design Open population-based cohort study.Setting Danish women operated 1978–2010.Cases 79 658 adjusted for age at surgery, period of surgery, tumour size, axillary lymph node status and hormone receptor status.Statistical analysis The association between OS and season of surgery was analysed by Cox proportional hazards regression models, at survival periods 0–1, 0–2, 0–5 and 0–10 years after surgery. A two-sided p value <0.05 was considered statistical significant.Results Only after adjustment for prognostic factors that may be influenced by vitamin D, 1-year survival was close to significantly associated season of surgery. 2, 5 and 10 years after surgery, the association between OS and season of surgery was not significant.Limitations Season is a surrogate measure of vitamin D.Conclusions The authors found no evidence of a seasonal variation in the survival after surgery for early breast cancer. Lack of seasonal variation in this study does not necessarily mean that vitamin D is of no importance for the outcome for breast cancer patients. |
| format | Article |
| id | doaj-art-f8fe826835874ca38d80a898e94c6af4 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-f8fe826835874ca38d80a898e94c6af42025-02-11T22:20:11ZengBMJ Publishing GroupBMJ Open2044-60552012-01-012110.1136/bmjopen-2011-000358Breast cancer survival and season of surgery: an ecological open cohort studyDorthe Teilum0Karsten D Bjerre1Anne M Tjønneland2Niels Kroman3Brystkirurgisk Klinik PBB, Copenhagen, DenmarkDanish Breast Cancer Cooperative Group, Copenhagen, DenmarkDanish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, DenmarkBrystkirurgisk Klinik PBB, Copenhagen, DenmarkBackground Vitamin D has been suggested to influence the incidence and prognosis of breast cancer, and studies have found better overall survival (OS) after diagnosis for breast cancer in summer–autumn, where the vitamin D level are expected to be highest.Objective To compare the prognostic outcome for early breast cancer patients operated at different seasons of the year.Design Open population-based cohort study.Setting Danish women operated 1978–2010.Cases 79 658 adjusted for age at surgery, period of surgery, tumour size, axillary lymph node status and hormone receptor status.Statistical analysis The association between OS and season of surgery was analysed by Cox proportional hazards regression models, at survival periods 0–1, 0–2, 0–5 and 0–10 years after surgery. A two-sided p value <0.05 was considered statistical significant.Results Only after adjustment for prognostic factors that may be influenced by vitamin D, 1-year survival was close to significantly associated season of surgery. 2, 5 and 10 years after surgery, the association between OS and season of surgery was not significant.Limitations Season is a surrogate measure of vitamin D.Conclusions The authors found no evidence of a seasonal variation in the survival after surgery for early breast cancer. Lack of seasonal variation in this study does not necessarily mean that vitamin D is of no importance for the outcome for breast cancer patients.https://bmjopen.bmj.com/content/2/1/e000358.full |
| spellingShingle | Dorthe Teilum Karsten D Bjerre Anne M Tjønneland Niels Kroman Breast cancer survival and season of surgery: an ecological open cohort study BMJ Open |
| title | Breast cancer survival and season of surgery: an ecological open cohort study |
| title_full | Breast cancer survival and season of surgery: an ecological open cohort study |
| title_fullStr | Breast cancer survival and season of surgery: an ecological open cohort study |
| title_full_unstemmed | Breast cancer survival and season of surgery: an ecological open cohort study |
| title_short | Breast cancer survival and season of surgery: an ecological open cohort study |
| title_sort | breast cancer survival and season of surgery an ecological open cohort study |
| url | https://bmjopen.bmj.com/content/2/1/e000358.full |
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