RNA binding proteins (RBPs) on genetic stability and diseases
RNA-binding proteins (RBPs) are integral components of cellular machinery, playing crucial roles in the regulation of gene expression and maintaining genetic stability. Their interactions with RNA molecules govern critical processes such as mRNA splicing, stability, localization, and translation, wh...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Global Medical Genetics |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2699940424000328 |
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| author | Abdullahi Tunde Aborode Ohilebo Abdulateef Abass Shaibu Nasiru Mary Ugunnushe Eigbobo Sumana Nefishatu Abdullahi Idowu Zainab Tiamiyu Aeshah A. Awaji Nike Idowu Babawale Roqeeb Busayo Qasim Mehmood Isreal Ayobami Onifade Sodiq Fakorede Ashraf Akintayo Akintola |
| author_facet | Abdullahi Tunde Aborode Ohilebo Abdulateef Abass Shaibu Nasiru Mary Ugunnushe Eigbobo Sumana Nefishatu Abdullahi Idowu Zainab Tiamiyu Aeshah A. Awaji Nike Idowu Babawale Roqeeb Busayo Qasim Mehmood Isreal Ayobami Onifade Sodiq Fakorede Ashraf Akintayo Akintola |
| author_sort | Abdullahi Tunde Aborode |
| collection | DOAJ |
| description | RNA-binding proteins (RBPs) are integral components of cellular machinery, playing crucial roles in the regulation of gene expression and maintaining genetic stability. Their interactions with RNA molecules govern critical processes such as mRNA splicing, stability, localization, and translation, which are essential for proper cellular function. These proteins interact with RNA molecules and other proteins to form ribonucleoprotein complexes (RNPs), hence controlling the fate of target RNAs. The interaction occurs via RNA recognition motif, the zinc finger domain, the KH domain and the double stranded RNA binding motif (all known as RNA-binding domains (RBDs). These domains are found within the coding sequences (intron and exon domains), 5’ untranslated regions (5’UTR) and 3’ untranslated regions (3’UTR). Dysregulation of RBPs can lead to genomic instability, contributing to various pathologies, including cancer neurodegenerative diseases, and metabolic disorders. This study comprehensively explores the multifaceted roles of RBPs in genetic stability, highlighting their involvement in maintaining genomic integrity through modulation of RNA processing and their implications in cellular signalling pathways. Furthermore, it discusses how aberrant RBP function can precipitate genetic instability and disease progression, emphasizing the therapeutic potential of targeting RBPs in restoring cellular homeostasis. Through an analysis of current literature, this study aims to delineate the critical role of RBPs in ensuring genetic stability and their promise as targets for innovative therapeutic strategies. |
| format | Article |
| id | doaj-art-f8fbdf76f2fb4c6f9cff2b669e734b07 |
| institution | OA Journals |
| issn | 2699-9404 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Global Medical Genetics |
| spelling | doaj-art-f8fbdf76f2fb4c6f9cff2b669e734b072025-08-20T02:03:46ZengKeAi Communications Co., Ltd.Global Medical Genetics2699-94042025-03-0112110003210.1016/j.gmg.2024.100032RNA binding proteins (RBPs) on genetic stability and diseasesAbdullahi Tunde Aborode0Ohilebo Abdulateef Abass1Shaibu Nasiru2Mary Ugunnushe Eigbobo3Sumana Nefishatu4Abdullahi Idowu5Zainab Tiamiyu6Aeshah A. Awaji7Nike Idowu8Babawale Roqeeb Busayo9Qasim Mehmood10Isreal Ayobami Onifade11Sodiq Fakorede12Ashraf Akintayo Akintola13Department of Research and Development, Healthy Africans Platform, Ibadan, NigeriaDepartment of Biochemistry, Ambrose Alli University Ekpoma, NigeriaDepartment of Research and Development, Healthy Africans Platform, Ibadan, Nigeria; Department of Biochemistry, Ambrose Alli University Ekpoma, NigeriaDepartment of Biochemistry, Ambrose Alli University Ekpoma, NigeriaDepartment of Biochemistry, Ambrose Alli University Ekpoma, NigeriaDepartment of Biological Sciences, Purdue University Fort Wayne, USADepartment of Biochemistry and Cancer Biology, Medical College of Georgia, Augusta University, USADepartment of Biology, Faculty of Science, University College of Taymaa, University of Tabuk, Tabuk 71491, Saudi ArabiaDepartment of Chemistry, University of Nebraska-Lincoln, USAUniversity of Ilesa, Ilesa, Osun state, NigeriaShifa Clinical Research Center, Shifa International Hospital, Islamabad, PakistanDepartment of Division of Family Health, Health Research Incorporated, New York State Department of Health, USADepartment of Physical Therapy, Rehabilitation Science, and Athletic Training, University of Kansas Medical Center, Kansas City, KS, USADepartment of Biology Education, Teachers College & Institute for Phylogenomics and Evolution, Kyungpook National University, Daegu, South Korea; Corresponding author.RNA-binding proteins (RBPs) are integral components of cellular machinery, playing crucial roles in the regulation of gene expression and maintaining genetic stability. Their interactions with RNA molecules govern critical processes such as mRNA splicing, stability, localization, and translation, which are essential for proper cellular function. These proteins interact with RNA molecules and other proteins to form ribonucleoprotein complexes (RNPs), hence controlling the fate of target RNAs. The interaction occurs via RNA recognition motif, the zinc finger domain, the KH domain and the double stranded RNA binding motif (all known as RNA-binding domains (RBDs). These domains are found within the coding sequences (intron and exon domains), 5’ untranslated regions (5’UTR) and 3’ untranslated regions (3’UTR). Dysregulation of RBPs can lead to genomic instability, contributing to various pathologies, including cancer neurodegenerative diseases, and metabolic disorders. This study comprehensively explores the multifaceted roles of RBPs in genetic stability, highlighting their involvement in maintaining genomic integrity through modulation of RNA processing and their implications in cellular signalling pathways. Furthermore, it discusses how aberrant RBP function can precipitate genetic instability and disease progression, emphasizing the therapeutic potential of targeting RBPs in restoring cellular homeostasis. Through an analysis of current literature, this study aims to delineate the critical role of RBPs in ensuring genetic stability and their promise as targets for innovative therapeutic strategies.http://www.sciencedirect.com/science/article/pii/S2699940424000328RNA binding proteinsGenetic stabilityDiseases |
| spellingShingle | Abdullahi Tunde Aborode Ohilebo Abdulateef Abass Shaibu Nasiru Mary Ugunnushe Eigbobo Sumana Nefishatu Abdullahi Idowu Zainab Tiamiyu Aeshah A. Awaji Nike Idowu Babawale Roqeeb Busayo Qasim Mehmood Isreal Ayobami Onifade Sodiq Fakorede Ashraf Akintayo Akintola RNA binding proteins (RBPs) on genetic stability and diseases Global Medical Genetics RNA binding proteins Genetic stability Diseases |
| title | RNA binding proteins (RBPs) on genetic stability and diseases |
| title_full | RNA binding proteins (RBPs) on genetic stability and diseases |
| title_fullStr | RNA binding proteins (RBPs) on genetic stability and diseases |
| title_full_unstemmed | RNA binding proteins (RBPs) on genetic stability and diseases |
| title_short | RNA binding proteins (RBPs) on genetic stability and diseases |
| title_sort | rna binding proteins rbps on genetic stability and diseases |
| topic | RNA binding proteins Genetic stability Diseases |
| url | http://www.sciencedirect.com/science/article/pii/S2699940424000328 |
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