Knockdown of PDPN in astrocytes reduces hippocampal inflammation in T2DM mice

Knockdown of PDPN in astrocytes reduces hippocampal inflammation in T2DM mice

AimsIndividuals with type 2 diabetes mellitus (T2DM) are at-risk for developing vascular dementia (VaD). Hyperglycemia leads to the activation of astrocytes. These activated cells produce proinflammatory mediators like cytokines or chemokines, that cause cerebrovascular damage. Previous sequencing s...

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Bibliographic Details
Main Authors: Xiaohang Wang, Qianqian Wang, Zhensheng Cai, Chengming Ni, Huan Wang, Hui Liu, Yusong Zhao, Jinbang Wang, Subo Liu, Xueying Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
type 2 diabetes mellitus
vascular dementia
PDPN
astrocytes
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1503807/full
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