Immunomodulatory and Antioxidant Effects of Pentoxifylline and Other Therapeutic Agents in The Management of Myocardial Injury
Background: Myocardial injury, particularly during myocardial infarction (MI), triggers an inflammatory response that is crucial for starting the myocardial healing process but is also responsible for cardiac remodeling and heart failure that can develop in as much as a quarter of the patients post-...
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| Language: | English |
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Ain Shams University
2023-12-01
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| Series: | Archives of Pharmaceutical Sciences Ain Shams University |
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| Online Access: | https://aps.journals.ekb.eg/article_332142.html |
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| author | Asmaa Saeed Nagwa A. Sabri Mohamed A. Saleh Marwa A. Ahmed |
| author_facet | Asmaa Saeed Nagwa A. Sabri Mohamed A. Saleh Marwa A. Ahmed |
| author_sort | Asmaa Saeed |
| collection | DOAJ |
| description | Background: Myocardial injury, particularly during myocardial infarction (MI), triggers an inflammatory response that is crucial for starting the myocardial healing process but is also responsible for cardiac remodeling and heart failure that can develop in as much as a quarter of the patients post-MI. Pentoxifylline (PTX) is a drug with potential cardiovascular benefits due to its anti-inflammatory and antioxidant properties. Aim: Highlight the immunomodulatory and antioxidant effects of PTX in the management of myocardial injury. Method: A search strategy was designed using medical subject headings (MeSH) terms of antioxidant effect, immunomodulatory, myocardial injury, and PTX for search on PubMed, and MEDLINE databases. Results and discussion: PTX has been studied for its potential therapeutic effects in managing myocardial injury. It was extensively investigated in-vivo as well as in human clinical trials and has provided promising results. Some of the promising findings include an anti-inflammatory and antioxidant effect with some beneficial clinical outcomes. These findings were evident as decreased levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and certain interleukins as IL-1, decreased oxidative stress markers as malondialdehyde (MDA) while increasing antioxidants such as glutathione, improved ejection fraction in some patients and improved mortality profile in one meta-analysis. Conclusion: It can be concluded that PTX has potential immunomodulatory and antioxidant effects in the management of myocardial injury. |
| format | Article |
| id | doaj-art-f8f12babef61478eb18ffdaf179a80bb |
| institution | OA Journals |
| issn | 2356-8380 2356-8399 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Ain Shams University |
| record_format | Article |
| series | Archives of Pharmaceutical Sciences Ain Shams University |
| spelling | doaj-art-f8f12babef61478eb18ffdaf179a80bb2025-08-20T02:00:06ZengAin Shams UniversityArchives of Pharmaceutical Sciences Ain Shams University2356-83802356-83992023-12-0172440456https://doi.org/10.21608/aps.2023.252451.1148Immunomodulatory and Antioxidant Effects of Pentoxifylline and Other Therapeutic Agents in The Management of Myocardial InjuryAsmaa Saeed 0Nagwa A. Sabri 1Mohamed A. Saleh2Marwa A. Ahmed 3Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.Department of Cardiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.Background: Myocardial injury, particularly during myocardial infarction (MI), triggers an inflammatory response that is crucial for starting the myocardial healing process but is also responsible for cardiac remodeling and heart failure that can develop in as much as a quarter of the patients post-MI. Pentoxifylline (PTX) is a drug with potential cardiovascular benefits due to its anti-inflammatory and antioxidant properties. Aim: Highlight the immunomodulatory and antioxidant effects of PTX in the management of myocardial injury. Method: A search strategy was designed using medical subject headings (MeSH) terms of antioxidant effect, immunomodulatory, myocardial injury, and PTX for search on PubMed, and MEDLINE databases. Results and discussion: PTX has been studied for its potential therapeutic effects in managing myocardial injury. It was extensively investigated in-vivo as well as in human clinical trials and has provided promising results. Some of the promising findings include an anti-inflammatory and antioxidant effect with some beneficial clinical outcomes. These findings were evident as decreased levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and certain interleukins as IL-1, decreased oxidative stress markers as malondialdehyde (MDA) while increasing antioxidants such as glutathione, improved ejection fraction in some patients and improved mortality profile in one meta-analysis. Conclusion: It can be concluded that PTX has potential immunomodulatory and antioxidant effects in the management of myocardial injury.https://aps.journals.ekb.eg/article_332142.htmlimmunomodulationinflammationmyocardial infarctionoxidative stressmyocardial injurypentoxifylline. |
| spellingShingle | Asmaa Saeed Nagwa A. Sabri Mohamed A. Saleh Marwa A. Ahmed Immunomodulatory and Antioxidant Effects of Pentoxifylline and Other Therapeutic Agents in The Management of Myocardial Injury Archives of Pharmaceutical Sciences Ain Shams University immunomodulation inflammation myocardial infarction oxidative stress myocardial injury pentoxifylline. |
| title | Immunomodulatory and Antioxidant Effects of Pentoxifylline and Other Therapeutic Agents in The Management of Myocardial Injury |
| title_full | Immunomodulatory and Antioxidant Effects of Pentoxifylline and Other Therapeutic Agents in The Management of Myocardial Injury |
| title_fullStr | Immunomodulatory and Antioxidant Effects of Pentoxifylline and Other Therapeutic Agents in The Management of Myocardial Injury |
| title_full_unstemmed | Immunomodulatory and Antioxidant Effects of Pentoxifylline and Other Therapeutic Agents in The Management of Myocardial Injury |
| title_short | Immunomodulatory and Antioxidant Effects of Pentoxifylline and Other Therapeutic Agents in The Management of Myocardial Injury |
| title_sort | immunomodulatory and antioxidant effects of pentoxifylline and other therapeutic agents in the management of myocardial injury |
| topic | immunomodulation inflammation myocardial infarction oxidative stress myocardial injury pentoxifylline. |
| url | https://aps.journals.ekb.eg/article_332142.html |
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