PARAPROTEINEMIC POLYNEUROPATHY ASSOCIATED WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE: СLINICAL CASE DESCRIPTION AND LITERATURE REVIEW
Monoclonal gammopathy of undetermined significance represents a number of conditions, the development of which is based on functional impairment of B-lymphocytes, which results in permanent pathological secretion of a single clone of immunoglobulins or their constituent chains. One of the leading an...
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| Format: | Article |
| Language: | Russian |
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Academician I.P. Pavlov First St. Petersburg State Medical University
2017-09-01
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| Series: | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
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| Online Access: | https://www.sci-notes.ru/jour/article/view/424 |
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| author | A. A. Yakovlev E. S. Tarabanova A. G. Smochilin R. A. Gapeshin M. V. Yakovleva |
| author_facet | A. A. Yakovlev E. S. Tarabanova A. G. Smochilin R. A. Gapeshin M. V. Yakovleva |
| author_sort | A. A. Yakovlev |
| collection | DOAJ |
| description | Monoclonal gammopathy of undetermined significance represents a number of conditions, the development of which is based on functional impairment of B-lymphocytes, which results in permanent pathological secretion of a single clone of immunoglobulins or their constituent chains. One of the leading and often the only clinical manifestation of monoclonal gammopathy is peripheral neuropathy associated with paraproteinemia. The article presents a clinical case of severe peripheral neuropathy associated with monoclonal gammopathy of undetermined significance. The diagnosis was confirmed on the basis of a comprehensive diagnosis, including screening paraproteinemic proteins in serum and a single urine sample is a method of immunofixation. Polyneuropathy was treated by using intravenous human immunoglobulin, as well as non-drug methods of rehabilitation (local cryotherapy, physical therapy and stabilometry). The therapy made a positive effect in reducing the symptoms, primarily the sensory and neuropathic components and polyneuropathy. |
| format | Article |
| id | doaj-art-f8e4eeb280f74b49a6dd555b8771b9a7 |
| institution | DOAJ |
| issn | 1607-4181 2541-8807 |
| language | Russian |
| publishDate | 2017-09-01 |
| publisher | Academician I.P. Pavlov First St. Petersburg State Medical University |
| record_format | Article |
| series | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
| spelling | doaj-art-f8e4eeb280f74b49a6dd555b8771b9a72025-08-20T03:00:35ZrusAcademician I.P. Pavlov First St. Petersburg State Medical UniversityУчёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова1607-41812541-88072017-09-01243718110.24884/1607-4181-2017-24-3-71-81356PARAPROTEINEMIC POLYNEUROPATHY ASSOCIATED WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE: СLINICAL CASE DESCRIPTION AND LITERATURE REVIEWA. A. Yakovlev0E. S. Tarabanova1A. G. Smochilin2R. A. Gapeshin3M. V. Yakovleva4Federal State Budgetary Educational Institution of Higher Education «Academician I. P. Pavlov First Saint-Petersburg State Medical University» of the Ministry of Healthcare of the Russian Federation; Federal State Budgetary Educational Institution of Higher Education North-Western State Medical University named after I. I. MechnikovFederal State Budgetary Educational Institution of Higher Education «Academician I. P. Pavlov First Saint-Petersburg State Medical University» of the Ministry of Healthcare of the Russian FederationFederal State Budgetary Educational Institution of Higher Education «Academician I. P. Pavlov First Saint-Petersburg State Medical University» of the Ministry of Healthcare of the Russian Federation; Federal State Budgetary Educational Institution of Higher Education SPSUFederal State Budgetary Educational Institution of Higher Education Saint-Petersburg State UniversityFederal State Budgetary Educational Institution of Higher Education «Academician I. P. Pavlov First Saint-Petersburg State Medical University» of the Ministry of Healthcare of the Russian FederationMonoclonal gammopathy of undetermined significance represents a number of conditions, the development of which is based on functional impairment of B-lymphocytes, which results in permanent pathological secretion of a single clone of immunoglobulins or their constituent chains. One of the leading and often the only clinical manifestation of monoclonal gammopathy is peripheral neuropathy associated with paraproteinemia. The article presents a clinical case of severe peripheral neuropathy associated with monoclonal gammopathy of undetermined significance. The diagnosis was confirmed on the basis of a comprehensive diagnosis, including screening paraproteinemic proteins in serum and a single urine sample is a method of immunofixation. Polyneuropathy was treated by using intravenous human immunoglobulin, as well as non-drug methods of rehabilitation (local cryotherapy, physical therapy and stabilometry). The therapy made a positive effect in reducing the symptoms, primarily the sensory and neuropathic components and polyneuropathy.https://www.sci-notes.ru/jour/article/view/424paraproteinemic polyneuropathymonoclonal gammapathy of undetermined significanceparaproteinelectroneuromyography |
| spellingShingle | A. A. Yakovlev E. S. Tarabanova A. G. Smochilin R. A. Gapeshin M. V. Yakovleva PARAPROTEINEMIC POLYNEUROPATHY ASSOCIATED WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE: СLINICAL CASE DESCRIPTION AND LITERATURE REVIEW Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова paraproteinemic polyneuropathy monoclonal gammapathy of undetermined significance paraprotein electroneuromyography |
| title | PARAPROTEINEMIC POLYNEUROPATHY ASSOCIATED WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE: СLINICAL CASE DESCRIPTION AND LITERATURE REVIEW |
| title_full | PARAPROTEINEMIC POLYNEUROPATHY ASSOCIATED WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE: СLINICAL CASE DESCRIPTION AND LITERATURE REVIEW |
| title_fullStr | PARAPROTEINEMIC POLYNEUROPATHY ASSOCIATED WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE: СLINICAL CASE DESCRIPTION AND LITERATURE REVIEW |
| title_full_unstemmed | PARAPROTEINEMIC POLYNEUROPATHY ASSOCIATED WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE: СLINICAL CASE DESCRIPTION AND LITERATURE REVIEW |
| title_short | PARAPROTEINEMIC POLYNEUROPATHY ASSOCIATED WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE: СLINICAL CASE DESCRIPTION AND LITERATURE REVIEW |
| title_sort | paraproteinemic polyneuropathy associated with monoclonal gammopathy of undetermined significance сlinical case description and literature review |
| topic | paraproteinemic polyneuropathy monoclonal gammapathy of undetermined significance paraprotein electroneuromyography |
| url | https://www.sci-notes.ru/jour/article/view/424 |
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