Effect of mannan-rich fractions and a mixture of sodium butyrate and zinc proteinate on performance, intestinal morphometry, and gene expression in broilers
This study evaluated the effects of isolated or combined prebiotics blended with sodium butyrate and zinc proteinate on performance, intestinal morphometry, and expression of genes associated with nutrient transport and immune response in broilers. 1,400 birds were randomly assigned to 5 treatments...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Italian Journal of Animal Science |
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| Online Access: | http://dx.doi.org/10.1080/1828051X.2023.2240850 |
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| author | M. A. S. Silva V. Ribeiro Júnior C. M. Silva L. F. C. Silva A. P. Del Vesco G. M. Oliveira Junior A. A. Calderano F. C. Tavernari A. Corassa C. O. Brito |
| author_facet | M. A. S. Silva V. Ribeiro Júnior C. M. Silva L. F. C. Silva A. P. Del Vesco G. M. Oliveira Junior A. A. Calderano F. C. Tavernari A. Corassa C. O. Brito |
| author_sort | M. A. S. Silva |
| collection | DOAJ |
| description | This study evaluated the effects of isolated or combined prebiotics blended with sodium butyrate and zinc proteinate on performance, intestinal morphometry, and expression of genes associated with nutrient transport and immune response in broilers. 1,400 birds were randomly assigned to 5 treatments (Negative control (NC) without antibiotic; Positive control (PC) with antibiotic; Prebiotic (Prebio) composed of mannan fractions; Blend, composed of sodium butyrate, hydrolysed yeast cell wall and zinc proteinate; and the combination Prebio + Blend), with eight replications and 35 birds per experimental unit. The PC led to higher weight gain (WG) and lowered feed conversion (FCR) from 1 to 7 days of life than the other treatments. The use of prebio and blend resulted in high WG from 22 to 42 days (1773; 1768.9 g, respectively). However, the combination of prebio + blend was similar to PC and NC treatments. The additives resulted in longer duodenal villi when administered alone and in ileal villi (p = 0.001) combined, with no effect on jejunal villi. Crypt depth and duodenal villus: crypt ratio was higher for both additives types. A significant difference among treatments in the expression of the sodium-dependent glucose transporter gene (SGLT1) was noted, with greater expression in birds that received NC. There was higher expression of the neutral and cationic amino acid transporter gene (y + LAT-2) with the prebio and blend, either alone or in combination. The prebio blend with sodium butyrate and zinc proteinate additives used separately in broiler diets supported beneficial changes in intestinal morphometry, nutrient absorption, and performance, indicating their value in antibiotic-free broiler production systems. |
| format | Article |
| id | doaj-art-f8e455e5f7dd4b0182cd896a0d012eca |
| institution | OA Journals |
| issn | 1594-4077 1828-051X |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Italian Journal of Animal Science |
| spelling | doaj-art-f8e455e5f7dd4b0182cd896a0d012eca2025-08-20T02:07:48ZengTaylor & Francis GroupItalian Journal of Animal Science1594-40771828-051X2023-12-0122172873810.1080/1828051X.2023.22408502240850Effect of mannan-rich fractions and a mixture of sodium butyrate and zinc proteinate on performance, intestinal morphometry, and gene expression in broilersM. A. S. Silva0V. Ribeiro Júnior1C. M. Silva2L. F. C. Silva3A. P. Del Vesco4G. M. Oliveira Junior5A. A. Calderano6F. C. Tavernari7A. Corassa8C. O. Brito9Department of Animal Science, Federal University of SergipeNucleus of Animal Science, Federal University of SergipeDepartment of Animal Science, Federal University of SergipeAlltech of BrazilDepartment of Animal Science, Federal University of SergipeDepartment of Animal Science, Federal University of SergipeDepartment of Animal Science, Federal University of ViçosaBrazilian Agricultural Research Corporation – EMBRAPA Swine and PoultryDepartment of Animal Science, Universidade Federal de Mato GrossoDepartment of Animal Science, Federal University of SergipeThis study evaluated the effects of isolated or combined prebiotics blended with sodium butyrate and zinc proteinate on performance, intestinal morphometry, and expression of genes associated with nutrient transport and immune response in broilers. 1,400 birds were randomly assigned to 5 treatments (Negative control (NC) without antibiotic; Positive control (PC) with antibiotic; Prebiotic (Prebio) composed of mannan fractions; Blend, composed of sodium butyrate, hydrolysed yeast cell wall and zinc proteinate; and the combination Prebio + Blend), with eight replications and 35 birds per experimental unit. The PC led to higher weight gain (WG) and lowered feed conversion (FCR) from 1 to 7 days of life than the other treatments. The use of prebio and blend resulted in high WG from 22 to 42 days (1773; 1768.9 g, respectively). However, the combination of prebio + blend was similar to PC and NC treatments. The additives resulted in longer duodenal villi when administered alone and in ileal villi (p = 0.001) combined, with no effect on jejunal villi. Crypt depth and duodenal villus: crypt ratio was higher for both additives types. A significant difference among treatments in the expression of the sodium-dependent glucose transporter gene (SGLT1) was noted, with greater expression in birds that received NC. There was higher expression of the neutral and cationic amino acid transporter gene (y + LAT-2) with the prebio and blend, either alone or in combination. The prebio blend with sodium butyrate and zinc proteinate additives used separately in broiler diets supported beneficial changes in intestinal morphometry, nutrient absorption, and performance, indicating their value in antibiotic-free broiler production systems.http://dx.doi.org/10.1080/1828051X.2023.2240850blendprebioticgrowth promotersgenesimmune response |
| spellingShingle | M. A. S. Silva V. Ribeiro Júnior C. M. Silva L. F. C. Silva A. P. Del Vesco G. M. Oliveira Junior A. A. Calderano F. C. Tavernari A. Corassa C. O. Brito Effect of mannan-rich fractions and a mixture of sodium butyrate and zinc proteinate on performance, intestinal morphometry, and gene expression in broilers Italian Journal of Animal Science blend prebiotic growth promoters genes immune response |
| title | Effect of mannan-rich fractions and a mixture of sodium butyrate and zinc proteinate on performance, intestinal morphometry, and gene expression in broilers |
| title_full | Effect of mannan-rich fractions and a mixture of sodium butyrate and zinc proteinate on performance, intestinal morphometry, and gene expression in broilers |
| title_fullStr | Effect of mannan-rich fractions and a mixture of sodium butyrate and zinc proteinate on performance, intestinal morphometry, and gene expression in broilers |
| title_full_unstemmed | Effect of mannan-rich fractions and a mixture of sodium butyrate and zinc proteinate on performance, intestinal morphometry, and gene expression in broilers |
| title_short | Effect of mannan-rich fractions and a mixture of sodium butyrate and zinc proteinate on performance, intestinal morphometry, and gene expression in broilers |
| title_sort | effect of mannan rich fractions and a mixture of sodium butyrate and zinc proteinate on performance intestinal morphometry and gene expression in broilers |
| topic | blend prebiotic growth promoters genes immune response |
| url | http://dx.doi.org/10.1080/1828051X.2023.2240850 |
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