Synthesis and Biological Activity of New Antimicrobial Agents - Hybrid Derivatives of Maleimides and Triindolylmethanes
Methods for the synthesis of hybrid molecules that combine the structure of a highly active antimicrobial compounds - tris(1-alkylindol-3-yl)methylium as well as 3-(indol-1-yl)maleimides that previously showed activity against some protein kinases have been developed. The main purpose of this study...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
LLC "Publishing House OKI"
2020-05-01
|
| Series: | Антибиотики и Химиотерапия |
| Subjects: | |
| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/89 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850063395071459328 |
|---|---|
| author | S. N. Lavrenov A. Yu. Simonov A. A. Panov S. A. Lakatosh E. B. Isakova E. A. Tsvigun O. P. Bychkova V. V. Tatarskiy E. S. Ivanova E. P. Mirchink A. M. Korolev A. S'. Trenin |
| author_facet | S. N. Lavrenov A. Yu. Simonov A. A. Panov S. A. Lakatosh E. B. Isakova E. A. Tsvigun O. P. Bychkova V. V. Tatarskiy E. S. Ivanova E. P. Mirchink A. M. Korolev A. S'. Trenin |
| author_sort | S. N. Lavrenov |
| collection | DOAJ |
| description | Methods for the synthesis of hybrid molecules that combine the structure of a highly active antimicrobial compounds - tris(1-alkylindol-3-yl)methylium as well as 3-(indol-1-yl)maleimides that previously showed activity against some protein kinases have been developed. The main purpose of this study was to investigate the influence of substituents on the activity of compounds against different test microorganisms, as well as their toxicity on human cells. For example, with the introduction of a fragment of maleimide, it was possible to reduce cytotoxicity by almost 40 times compared to the original prototype in some cases. At the same time, antimicrobial activity of the new substance remained approximately at the same level. |
| format | Article |
| id | doaj-art-f8e027d1c0eb45bda3590dbd60cfdfea |
| institution | DOAJ |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-f8e027d1c0eb45bda3590dbd60cfdfea2025-08-20T02:49:36ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01637-841088Synthesis and Biological Activity of New Antimicrobial Agents - Hybrid Derivatives of Maleimides and TriindolylmethanesS. N. Lavrenov0A. Yu. Simonov1A. A. Panov2S. A. Lakatosh3E. B. Isakova4E. A. Tsvigun5O. P. Bychkova6V. V. Tatarskiy7E. S. Ivanova8E. P. Mirchink9A. M. Korolev10A. S'. Trenin11Gause Institute of New AntibioticsGause Institute of New AntibioticsGause Institute of New AntibioticsGause Institute of New AntibioticsGause Institute of New AntibioticsGause Institute of New AntibioticsGause Institute of New AntibioticsN. N. Blokhin National Medical Recearch Center of Oncology of the Ministry of Health of the Russian FederationN. N. Blokhin National Medical Recearch Center of Oncology of the Ministry of Health of the Russian FederationGause Institute of New AntibioticsGause Institute of New AntibioticsGause Institute of New AntibioticsMethods for the synthesis of hybrid molecules that combine the structure of a highly active antimicrobial compounds - tris(1-alkylindol-3-yl)methylium as well as 3-(indol-1-yl)maleimides that previously showed activity against some protein kinases have been developed. The main purpose of this study was to investigate the influence of substituents on the activity of compounds against different test microorganisms, as well as their toxicity on human cells. For example, with the introduction of a fragment of maleimide, it was possible to reduce cytotoxicity by almost 40 times compared to the original prototype in some cases. At the same time, antimicrobial activity of the new substance remained approximately at the same level.https://www.antibiotics-chemotherapy.ru/jour/article/view/89hybrid antibioticstriindolylmethane derivativesmaleimideschemical synthesisantibacterial and antifungal activity in vitrorelations between structure and biological activity |
| spellingShingle | S. N. Lavrenov A. Yu. Simonov A. A. Panov S. A. Lakatosh E. B. Isakova E. A. Tsvigun O. P. Bychkova V. V. Tatarskiy E. S. Ivanova E. P. Mirchink A. M. Korolev A. S'. Trenin Synthesis and Biological Activity of New Antimicrobial Agents - Hybrid Derivatives of Maleimides and Triindolylmethanes Антибиотики и Химиотерапия hybrid antibiotics triindolylmethane derivatives maleimides chemical synthesis antibacterial and antifungal activity in vitro relations between structure and biological activity |
| title | Synthesis and Biological Activity of New Antimicrobial Agents - Hybrid Derivatives of Maleimides and Triindolylmethanes |
| title_full | Synthesis and Biological Activity of New Antimicrobial Agents - Hybrid Derivatives of Maleimides and Triindolylmethanes |
| title_fullStr | Synthesis and Biological Activity of New Antimicrobial Agents - Hybrid Derivatives of Maleimides and Triindolylmethanes |
| title_full_unstemmed | Synthesis and Biological Activity of New Antimicrobial Agents - Hybrid Derivatives of Maleimides and Triindolylmethanes |
| title_short | Synthesis and Biological Activity of New Antimicrobial Agents - Hybrid Derivatives of Maleimides and Triindolylmethanes |
| title_sort | synthesis and biological activity of new antimicrobial agents hybrid derivatives of maleimides and triindolylmethanes |
| topic | hybrid antibiotics triindolylmethane derivatives maleimides chemical synthesis antibacterial and antifungal activity in vitro relations between structure and biological activity |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/89 |
| work_keys_str_mv | AT snlavrenov synthesisandbiologicalactivityofnewantimicrobialagentshybridderivativesofmaleimidesandtriindolylmethanes AT ayusimonov synthesisandbiologicalactivityofnewantimicrobialagentshybridderivativesofmaleimidesandtriindolylmethanes AT aapanov synthesisandbiologicalactivityofnewantimicrobialagentshybridderivativesofmaleimidesandtriindolylmethanes AT salakatosh synthesisandbiologicalactivityofnewantimicrobialagentshybridderivativesofmaleimidesandtriindolylmethanes AT ebisakova synthesisandbiologicalactivityofnewantimicrobialagentshybridderivativesofmaleimidesandtriindolylmethanes AT eatsvigun synthesisandbiologicalactivityofnewantimicrobialagentshybridderivativesofmaleimidesandtriindolylmethanes AT opbychkova synthesisandbiologicalactivityofnewantimicrobialagentshybridderivativesofmaleimidesandtriindolylmethanes AT vvtatarskiy synthesisandbiologicalactivityofnewantimicrobialagentshybridderivativesofmaleimidesandtriindolylmethanes AT esivanova synthesisandbiologicalactivityofnewantimicrobialagentshybridderivativesofmaleimidesandtriindolylmethanes AT epmirchink synthesisandbiologicalactivityofnewantimicrobialagentshybridderivativesofmaleimidesandtriindolylmethanes AT amkorolev synthesisandbiologicalactivityofnewantimicrobialagentshybridderivativesofmaleimidesandtriindolylmethanes AT astrenin synthesisandbiologicalactivityofnewantimicrobialagentshybridderivativesofmaleimidesandtriindolylmethanes |