Impact of Hyponatremia and ADH Secretion in MIS-C and COVID-19: An Integrative Approach of Prognostic and Diagnostic Markers
The COVID-19 pandemic has introduced challenges in pediatric care, especially due to the emergence of Multisystem Inflammatory Syndrome in Children (MIS-C), a severe condition associated with SARS-CoV-2 infection. This study investigated the impact of hyponatremia and antidiuretic hormone (ADH) secr...
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2024-10-01
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| author | Diana-Andreea Ciortea Carmen Loredana Petrea (Cliveți) Sorin Ion Berbece Silvia Fotea Iolanda Cristina Vivisenco Gabriela Gurău Mădălina Nicoleta Matei Aurel Nechita |
| author_facet | Diana-Andreea Ciortea Carmen Loredana Petrea (Cliveți) Sorin Ion Berbece Silvia Fotea Iolanda Cristina Vivisenco Gabriela Gurău Mădălina Nicoleta Matei Aurel Nechita |
| author_sort | Diana-Andreea Ciortea |
| collection | DOAJ |
| description | The COVID-19 pandemic has introduced challenges in pediatric care, especially due to the emergence of Multisystem Inflammatory Syndrome in Children (MIS-C), a severe condition associated with SARS-CoV-2 infection. This study investigated the impact of hyponatremia and antidiuretic hormone (ADH) secretion corelated to clinical outcomes in these patients. We conducted a retrospective cohort study, including 118 pediatric patients, with a detailed sub-cohort analysis of 53 patients for ADH secretion markers. Hyponatremia, defined by age-specific sodium thresholds, was present in 47.22% of MIS-C cases and 28.04% of COVID-19 cases. Ordinal logistic regression analysis revealed that severe hyponatremia significantly increased the likelihood of more severe clinical outcomes (β = 3.514, <i>p</i> < 0.001). A significant correlation was found between hyponatremia and prolonged hospitalization. For ADH secretion, a predictive model using ridge regression was analysed, which demonstrated that serum sodium level, U/P ratio, and hospitalization duration are key predictors of SIADH. This model fit was assessed using the ROC curve with an AUC of 0.96, indicating reliable model performance. Our findings underscore the significant role of hyponatremia on the clinical severity and hospitalization outcome of COVID-19 and MIS-C in pediatric patients. |
| format | Article |
| id | doaj-art-f8cd79298ff64e22935b5d45743d107d |
| institution | Kabale University |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj-art-f8cd79298ff64e22935b5d45743d107d2024-11-26T17:57:47ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452024-10-014611117491177110.3390/cimb46110698Impact of Hyponatremia and ADH Secretion in MIS-C and COVID-19: An Integrative Approach of Prognostic and Diagnostic MarkersDiana-Andreea Ciortea0Carmen Loredana Petrea (Cliveți)1Sorin Ion Berbece2Silvia Fotea3Iolanda Cristina Vivisenco4Gabriela Gurău5Mădălina Nicoleta Matei6Aurel Nechita7Faculty of Medicine and Pharmacy, University “Dunarea de Jos” of Galati, 800201 Galati, RomaniaFaculty of Medicine and Pharmacy, University “Dunarea de Jos” of Galati, 800201 Galati, RomaniaFaculty of Medicine and Pharmacy, University “Dunarea de Jos” of Galati, 800201 Galati, RomaniaFaculty of Medicine and Pharmacy, University “Dunarea de Jos” of Galati, 800201 Galati, RomaniaFaculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 030167 Bucharest, RomaniaFaculty of Medicine and Pharmacy, University “Dunarea de Jos” of Galati, 800201 Galati, RomaniaFaculty of Medicine and Pharmacy, University “Dunarea de Jos” of Galati, 800201 Galati, RomaniaFaculty of Medicine and Pharmacy, University “Dunarea de Jos” of Galati, 800201 Galati, RomaniaThe COVID-19 pandemic has introduced challenges in pediatric care, especially due to the emergence of Multisystem Inflammatory Syndrome in Children (MIS-C), a severe condition associated with SARS-CoV-2 infection. This study investigated the impact of hyponatremia and antidiuretic hormone (ADH) secretion corelated to clinical outcomes in these patients. We conducted a retrospective cohort study, including 118 pediatric patients, with a detailed sub-cohort analysis of 53 patients for ADH secretion markers. Hyponatremia, defined by age-specific sodium thresholds, was present in 47.22% of MIS-C cases and 28.04% of COVID-19 cases. Ordinal logistic regression analysis revealed that severe hyponatremia significantly increased the likelihood of more severe clinical outcomes (β = 3.514, <i>p</i> < 0.001). A significant correlation was found between hyponatremia and prolonged hospitalization. For ADH secretion, a predictive model using ridge regression was analysed, which demonstrated that serum sodium level, U/P ratio, and hospitalization duration are key predictors of SIADH. This model fit was assessed using the ROC curve with an AUC of 0.96, indicating reliable model performance. Our findings underscore the significant role of hyponatremia on the clinical severity and hospitalization outcome of COVID-19 and MIS-C in pediatric patients.https://www.mdpi.com/1467-3045/46/11/698hyponatremiaADHCOVID-19MIS-CpolyuriaSIADH |
| spellingShingle | Diana-Andreea Ciortea Carmen Loredana Petrea (Cliveți) Sorin Ion Berbece Silvia Fotea Iolanda Cristina Vivisenco Gabriela Gurău Mădălina Nicoleta Matei Aurel Nechita Impact of Hyponatremia and ADH Secretion in MIS-C and COVID-19: An Integrative Approach of Prognostic and Diagnostic Markers Current Issues in Molecular Biology hyponatremia ADH COVID-19 MIS-C polyuria SIADH |
| title | Impact of Hyponatremia and ADH Secretion in MIS-C and COVID-19: An Integrative Approach of Prognostic and Diagnostic Markers |
| title_full | Impact of Hyponatremia and ADH Secretion in MIS-C and COVID-19: An Integrative Approach of Prognostic and Diagnostic Markers |
| title_fullStr | Impact of Hyponatremia and ADH Secretion in MIS-C and COVID-19: An Integrative Approach of Prognostic and Diagnostic Markers |
| title_full_unstemmed | Impact of Hyponatremia and ADH Secretion in MIS-C and COVID-19: An Integrative Approach of Prognostic and Diagnostic Markers |
| title_short | Impact of Hyponatremia and ADH Secretion in MIS-C and COVID-19: An Integrative Approach of Prognostic and Diagnostic Markers |
| title_sort | impact of hyponatremia and adh secretion in mis c and covid 19 an integrative approach of prognostic and diagnostic markers |
| topic | hyponatremia ADH COVID-19 MIS-C polyuria SIADH |
| url | https://www.mdpi.com/1467-3045/46/11/698 |
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