Singular case report of familial hypocalciuric hypercalcemia: a rare diagnosis of hypercalcemia in the older people
Objective to report a case of familial hypocalciuric hypercalcemia (FHH) in an older patient and highlight the diagnostic challenges in geriatric populations.Case presentation We report the diagnosis of FHH in an 88-year-old polypathological patient with hypercalcemia discovered during a check-up fo...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
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| Series: | The Aging Male |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/13685538.2024.2436877 |
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| Summary: | Objective to report a case of familial hypocalciuric hypercalcemia (FHH) in an older patient and highlight the diagnostic challenges in geriatric populations.Case presentation We report the diagnosis of FHH in an 88-year-old polypathological patient with hypercalcemia discovered during a check-up for cardiac decompensation. Despite a confusing clinical presentation with gout symptoms, including repeated episodes of knee arthritis, persistent hypercalcemia conducted further investigations. Biological tests excluded primary or hyperparathyroidism and malignancy-related hyperparathyroidism, confirming the diagnosis of FHH through the detection of an inhibitory mutation in the calcium-sensing receptor gene.Conclusion This case suggests to clinicians the possibility of FHH in older patients with unexplained hypercalcemia. In geriatric patients, the diagnosis is complicated because of the poly-pathology: here hypercalcemia was associated with a confusing gout crisis, which was triggered by diuretic treatment for heart failure. |
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| ISSN: | 1368-5538 1473-0790 |