Latent Autoimmune Diabetes of Adults Due to Positive Zinc Transporter 8 Antibody
This case series reports 3 patients who were diagnosed with type 2 diabetes mellitus (T2DM), treated with oral antidiabetic medications, referred to our endocrinology clinic due to poor glycemic control, and were diagnosed with latent autoimmune diabetes of adults due to the isolated presence of ZnT...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2025-06-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2024.1092 |
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| _version_ | 1850131671239622656 |
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| author | Jacob Maniattu Mc Anto Antony Siddharth Patel Alvin Maliakal |
| author_facet | Jacob Maniattu Mc Anto Antony Siddharth Patel Alvin Maliakal |
| author_sort | Jacob Maniattu |
| collection | DOAJ |
| description | This case series reports 3 patients who were diagnosed with type 2 diabetes mellitus (T2DM), treated with oral antidiabetic medications, referred to our endocrinology clinic due to poor glycemic control, and were diagnosed with latent autoimmune diabetes of adults due to the isolated presence of ZnT8 antibody. Our cases highlight a few important learning points, such as maintaining a high degree of suspicion for the development of autoimmunity in a patient with T2DM with progressive or rapid worsening in glycemic control and the need to include the ZnT8 antibody in the panel of other diabetes antibodies during the work-up for autoimmune DM. |
| format | Article |
| id | doaj-art-f8a1662383fa44de8a32d2838247a0e4 |
| institution | OA Journals |
| issn | 2767-7664 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-f8a1662383fa44de8a32d2838247a0e42025-08-20T02:32:22ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642025-06-014610.7326/aimcc.2024.1092Latent Autoimmune Diabetes of Adults Due to Positive Zinc Transporter 8 AntibodyJacob Maniattu0Mc Anto Antony1Siddharth Patel2Alvin Maliakal31Eastern Virginia Medical School, Norfolk, Virginia2Medical University of South Carolina/AnMed Campus, Anderson, South Carolina3Decatur Morgan Hospital, Decatur, Alabama3Decatur Morgan Hospital, Decatur, AlabamaThis case series reports 3 patients who were diagnosed with type 2 diabetes mellitus (T2DM), treated with oral antidiabetic medications, referred to our endocrinology clinic due to poor glycemic control, and were diagnosed with latent autoimmune diabetes of adults due to the isolated presence of ZnT8 antibody. Our cases highlight a few important learning points, such as maintaining a high degree of suspicion for the development of autoimmunity in a patient with T2DM with progressive or rapid worsening in glycemic control and the need to include the ZnT8 antibody in the panel of other diabetes antibodies during the work-up for autoimmune DM.https://www.acpjournals.org/doi/10.7326/aimcc.2024.1092 |
| spellingShingle | Jacob Maniattu Mc Anto Antony Siddharth Patel Alvin Maliakal Latent Autoimmune Diabetes of Adults Due to Positive Zinc Transporter 8 Antibody Annals of Internal Medicine: Clinical Cases |
| title | Latent Autoimmune Diabetes of Adults Due to Positive Zinc Transporter 8 Antibody |
| title_full | Latent Autoimmune Diabetes of Adults Due to Positive Zinc Transporter 8 Antibody |
| title_fullStr | Latent Autoimmune Diabetes of Adults Due to Positive Zinc Transporter 8 Antibody |
| title_full_unstemmed | Latent Autoimmune Diabetes of Adults Due to Positive Zinc Transporter 8 Antibody |
| title_short | Latent Autoimmune Diabetes of Adults Due to Positive Zinc Transporter 8 Antibody |
| title_sort | latent autoimmune diabetes of adults due to positive zinc transporter 8 antibody |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2024.1092 |
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