Anti-HMGCR Specificity of HALIP: A Confirmatory Study
A distinctive new indirect immunofluorescence pattern in liver tissue has been associated with anti-HMGCR autoantibodies. It is known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern). In this study, we furthered the original studies to demonstrate the association of anti-HMGCR antibodies...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/6292631 |
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| author | Andrés Baucells Maria Angeles Martínez Marcelo Alvarado-Cardenas Anaís Mariscal Laura Martinez-Martinez Cándido Juárez Albert Selva-O’Callaghan |
| author_facet | Andrés Baucells Maria Angeles Martínez Marcelo Alvarado-Cardenas Anaís Mariscal Laura Martinez-Martinez Cándido Juárez Albert Selva-O’Callaghan |
| author_sort | Andrés Baucells |
| collection | DOAJ |
| description | A distinctive new indirect immunofluorescence pattern in liver tissue has been associated with anti-HMGCR autoantibodies. It is known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern). In this study, we furthered the original studies to demonstrate the association of anti-HMGCR antibodies with the HALIP. Human anti-HMGCR antibodies from patients’ sera were purified and incubated with rat triple tissue (kidney/stomach/liver). A characteristic HALIP was observed. Additionally, a colocalization assay of human anti-HMGCR antibodies with rabbit polyclonal anti-HMGCR antibodies showed colocalization of both immunofluorescence patterns. This study confirms that the HALIP is due to human anti-HMGCR antibodies. |
| format | Article |
| id | doaj-art-f8a048a5dee949819583b9e2492ecc57 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-f8a048a5dee949819583b9e2492ecc572025-02-03T06:45:48ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/62926316292631Anti-HMGCR Specificity of HALIP: A Confirmatory StudyAndrés Baucells0Maria Angeles Martínez1Marcelo Alvarado-Cardenas2Anaís Mariscal3Laura Martinez-Martinez4Cándido Juárez5Albert Selva-O’Callaghan6Immunology Department, Hospital de la Santa Creu i Sant Pau, Barcelona 08041, SpainImmunology Department, Hospital de la Santa Creu i Sant Pau, Barcelona 08041, SpainSystemic Autoimmune Diseases Unit, Hospital Vall d’Hebrón, Medicine Department, Universidad Autónoma de Barcelona, Barcelona, SpainImmunology Department, Hospital de la Santa Creu i Sant Pau, Barcelona 08041, SpainImmunology Department, Hospital de la Santa Creu i Sant Pau, Barcelona 08041, SpainImmunology Department, Hospital de la Santa Creu i Sant Pau, Barcelona 08041, SpainSystemic Autoimmune Diseases Unit, Hospital Vall d’Hebrón, Medicine Department, Universidad Autónoma de Barcelona, Barcelona, SpainA distinctive new indirect immunofluorescence pattern in liver tissue has been associated with anti-HMGCR autoantibodies. It is known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern). In this study, we furthered the original studies to demonstrate the association of anti-HMGCR antibodies with the HALIP. Human anti-HMGCR antibodies from patients’ sera were purified and incubated with rat triple tissue (kidney/stomach/liver). A characteristic HALIP was observed. Additionally, a colocalization assay of human anti-HMGCR antibodies with rabbit polyclonal anti-HMGCR antibodies showed colocalization of both immunofluorescence patterns. This study confirms that the HALIP is due to human anti-HMGCR antibodies.http://dx.doi.org/10.1155/2020/6292631 |
| spellingShingle | Andrés Baucells Maria Angeles Martínez Marcelo Alvarado-Cardenas Anaís Mariscal Laura Martinez-Martinez Cándido Juárez Albert Selva-O’Callaghan Anti-HMGCR Specificity of HALIP: A Confirmatory Study Journal of Immunology Research |
| title | Anti-HMGCR Specificity of HALIP: A Confirmatory Study |
| title_full | Anti-HMGCR Specificity of HALIP: A Confirmatory Study |
| title_fullStr | Anti-HMGCR Specificity of HALIP: A Confirmatory Study |
| title_full_unstemmed | Anti-HMGCR Specificity of HALIP: A Confirmatory Study |
| title_short | Anti-HMGCR Specificity of HALIP: A Confirmatory Study |
| title_sort | anti hmgcr specificity of halip a confirmatory study |
| url | http://dx.doi.org/10.1155/2020/6292631 |
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