Evaluation of Coenzyme Q10 Redox Status as a Biomarker of Oxidative Stress
The article examines the role of ubiquinone as a redox molecule whose functions consist in electron transport in the mitochondrial respiratory chain and regeneration of endogenous antioxidants. Changes in electron redox pathways cause uncontrolled release of reactive oxygen species, which leads to o...
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| Format: | Article |
| Language: | Russian |
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Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)
2019-09-01
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| Series: | Регуляторные исследования и экспертиза лекарственных средств |
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| Online Access: | https://www.vedomostincesmp.ru/jour/article/view/251 |
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| author | O. A. Goroshko L. M. Krasnykh V. G. Kukes V. I. Zozina |
| author_facet | O. A. Goroshko L. M. Krasnykh V. G. Kukes V. I. Zozina |
| author_sort | O. A. Goroshko |
| collection | DOAJ |
| description | The article examines the role of ubiquinone as a redox molecule whose functions consist in electron transport in the mitochondrial respiratory chain and regeneration of endogenous antioxidants. Changes in electron redox pathways cause uncontrolled release of reactive oxygen species, which leads to oxidative stress and development of pathologies. The objective of the study was to determine the content of coenzyme Q10 and its redox status in the human body as a biomarker of oxidative stress in various pathologies. This was achieved by assessing and consolidating data on changes in concentrations of the oxidized, reduced ubiquinone forms and total ubiquinone in various pathologies. Total serum ubiquinone was reduced in patients with chronic heart failure (0.68 μmol/L) compared with the control group (0.97 μmol/L). The redox status, expressed as the [ubiquinol]/ [ubiquinone] concentration ratio, decreased in patients with coronary heart disease (0.49 ± 0.34), diabetes (0.26 ± 0.16) compared with the healthy subjects (1.23–1.41). A negative correlation with malonic dialdehyde was observed. The authors analysed the possibility of assessing the efficacy of statin therapy by plasma ubiquinone concentration in patients. Patients with hyperlipidemia who received statins showed a statistically significant reduction in ubiquinol concentration after taking the drug (from 0.81 to 0.46 μg/mL) and the [ubiquinone]/[total ubiquinone] ratio (from 11 to 10 %), which confirms the potential mechanism of statinassociated muscle injury development. Thus, coenzyme Q10 redox status, as well as the concentrations of oxidized, reduced and total ubiquinone can be effective biomarkers of oxidative stress in cardiovascular diseases, diabetes, as well as an important indicator in evaluating the efficacy of hyperlipidemia treatment. |
| format | Article |
| id | doaj-art-f89fa6c155174aeaa7b594cfb3428247 |
| institution | Kabale University |
| issn | 3034-3062 3034-3453 |
| language | Russian |
| publishDate | 2019-09-01 |
| publisher | Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’) |
| record_format | Article |
| series | Регуляторные исследования и экспертиза лекарственных средств |
| spelling | doaj-art-f89fa6c155174aeaa7b594cfb34282472025-08-20T03:57:31ZrusFederal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)Регуляторные исследования и экспертиза лекарственных средств3034-30623034-34532019-09-019314615210.30895/1991-2919-2019-9-3-146-152210Evaluation of Coenzyme Q10 Redox Status as a Biomarker of Oxidative StressO. A. Goroshko0L. M. Krasnykh1V. G. Kukes2V. I. Zozina3Scientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsI. M. Sechenov First Moscow State Medical UniversityThe article examines the role of ubiquinone as a redox molecule whose functions consist in electron transport in the mitochondrial respiratory chain and regeneration of endogenous antioxidants. Changes in electron redox pathways cause uncontrolled release of reactive oxygen species, which leads to oxidative stress and development of pathologies. The objective of the study was to determine the content of coenzyme Q10 and its redox status in the human body as a biomarker of oxidative stress in various pathologies. This was achieved by assessing and consolidating data on changes in concentrations of the oxidized, reduced ubiquinone forms and total ubiquinone in various pathologies. Total serum ubiquinone was reduced in patients with chronic heart failure (0.68 μmol/L) compared with the control group (0.97 μmol/L). The redox status, expressed as the [ubiquinol]/ [ubiquinone] concentration ratio, decreased in patients with coronary heart disease (0.49 ± 0.34), diabetes (0.26 ± 0.16) compared with the healthy subjects (1.23–1.41). A negative correlation with malonic dialdehyde was observed. The authors analysed the possibility of assessing the efficacy of statin therapy by plasma ubiquinone concentration in patients. Patients with hyperlipidemia who received statins showed a statistically significant reduction in ubiquinol concentration after taking the drug (from 0.81 to 0.46 μg/mL) and the [ubiquinone]/[total ubiquinone] ratio (from 11 to 10 %), which confirms the potential mechanism of statinassociated muscle injury development. Thus, coenzyme Q10 redox status, as well as the concentrations of oxidized, reduced and total ubiquinone can be effective biomarkers of oxidative stress in cardiovascular diseases, diabetes, as well as an important indicator in evaluating the efficacy of hyperlipidemia treatment.https://www.vedomostincesmp.ru/jour/article/view/251ubiquinoneubiquinolcoenzyme q10redox statuscardiovascular pathologies, hyperlipidemia, statins |
| spellingShingle | O. A. Goroshko L. M. Krasnykh V. G. Kukes V. I. Zozina Evaluation of Coenzyme Q10 Redox Status as a Biomarker of Oxidative Stress Регуляторные исследования и экспертиза лекарственных средств ubiquinone ubiquinol coenzyme q10 redox status cardiovascular pathologies, hyperlipidemia, statins |
| title | Evaluation of Coenzyme Q10 Redox Status as a Biomarker of Oxidative Stress |
| title_full | Evaluation of Coenzyme Q10 Redox Status as a Biomarker of Oxidative Stress |
| title_fullStr | Evaluation of Coenzyme Q10 Redox Status as a Biomarker of Oxidative Stress |
| title_full_unstemmed | Evaluation of Coenzyme Q10 Redox Status as a Biomarker of Oxidative Stress |
| title_short | Evaluation of Coenzyme Q10 Redox Status as a Biomarker of Oxidative Stress |
| title_sort | evaluation of coenzyme q10 redox status as a biomarker of oxidative stress |
| topic | ubiquinone ubiquinol coenzyme q10 redox status cardiovascular pathologies, hyperlipidemia, statins |
| url | https://www.vedomostincesmp.ru/jour/article/view/251 |
| work_keys_str_mv | AT oagoroshko evaluationofcoenzymeq10redoxstatusasabiomarkerofoxidativestress AT lmkrasnykh evaluationofcoenzymeq10redoxstatusasabiomarkerofoxidativestress AT vgkukes evaluationofcoenzymeq10redoxstatusasabiomarkerofoxidativestress AT vizozina evaluationofcoenzymeq10redoxstatusasabiomarkerofoxidativestress |