Sleep, Neuroendocrine Disorders, And the Bidirectional Relationship between the Hypothalamic-Pituitary-Adrenal Axis: A Mini-Review
This review explores the intricate and bidirectional relationships between the hypothalamic-pituitary-adrenal (HPA) axis, sleep architecture and regulation, and the manifestation of various neuroendocrine disorders. The HPA axis, a critical component of the stress response system, exhibits diurnal...
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| Language: | English |
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Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)
2025-04-01
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| Series: | Journal of Applied Sciences and Environmental Management |
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| Online Access: | https://www.ajol.info/index.php/jasem/article/view/293743 |
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| author | O. A. Udi |
| author_facet | O. A. Udi |
| author_sort | O. A. Udi |
| collection | DOAJ |
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This review explores the intricate and bidirectional relationships between the hypothalamic-pituitary-adrenal (HPA) axis, sleep architecture and regulation, and the manifestation of various neuroendocrine disorders. The HPA axis, a critical component of the stress response system, exhibits diurnal rhythmicity and is profoundly influenced by sleep. Conversely, HPA axis activity significantly impacts sleep quality, duration, and consolidation. Disruptions in either the HPA axis or sleep can lead to or exacerbate a range of neuroendocrine disorders, including depression, anxiety disorders, Cushing's syndrome, Addison's disease, and sleep disorders themselves (e.g., insomnia, sleep apnea). This review examines the physiological mechanisms underlying these interactions, focusing on the roles of key hormones like cortisol, corticotropin-releasing hormone (CRH), and adrenocorticotropic hormone (ACTH). Furthermore, it discusses the clinical implications of these interrelationships, including diagnostic considerations and potential therapeutic strategies that target the HPA axis and sleep pathways to improve outcomes in individuals with neuroendocrine disorders. A thorough understanding of this complex interplay is crucial for developing effective interventions and personalized treatment approaches.
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| format | Article |
| id | doaj-art-f899eddbaeeb4788a7cb8e280fcbf207 |
| institution | DOAJ |
| issn | 2659-1502 2659-1499 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP) |
| record_format | Article |
| series | Journal of Applied Sciences and Environmental Management |
| spelling | doaj-art-f899eddbaeeb4788a7cb8e280fcbf2072025-08-20T03:18:41ZengJoint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)Journal of Applied Sciences and Environmental Management2659-15022659-14992025-04-01294Sleep, Neuroendocrine Disorders, And the Bidirectional Relationship between the Hypothalamic-Pituitary-Adrenal Axis: A Mini-ReviewO. A. Udi This review explores the intricate and bidirectional relationships between the hypothalamic-pituitary-adrenal (HPA) axis, sleep architecture and regulation, and the manifestation of various neuroendocrine disorders. The HPA axis, a critical component of the stress response system, exhibits diurnal rhythmicity and is profoundly influenced by sleep. Conversely, HPA axis activity significantly impacts sleep quality, duration, and consolidation. Disruptions in either the HPA axis or sleep can lead to or exacerbate a range of neuroendocrine disorders, including depression, anxiety disorders, Cushing's syndrome, Addison's disease, and sleep disorders themselves (e.g., insomnia, sleep apnea). This review examines the physiological mechanisms underlying these interactions, focusing on the roles of key hormones like cortisol, corticotropin-releasing hormone (CRH), and adrenocorticotropic hormone (ACTH). Furthermore, it discusses the clinical implications of these interrelationships, including diagnostic considerations and potential therapeutic strategies that target the HPA axis and sleep pathways to improve outcomes in individuals with neuroendocrine disorders. A thorough understanding of this complex interplay is crucial for developing effective interventions and personalized treatment approaches. https://www.ajol.info/index.php/jasem/article/view/293743Sleep Apnea; Cushing's syndrome; Addison's disease; Stress Response; Hypothalamic-Pituitary-Adrenal |
| spellingShingle | O. A. Udi Sleep, Neuroendocrine Disorders, And the Bidirectional Relationship between the Hypothalamic-Pituitary-Adrenal Axis: A Mini-Review Journal of Applied Sciences and Environmental Management Sleep Apnea; Cushing's syndrome; Addison's disease; Stress Response; Hypothalamic-Pituitary-Adrenal |
| title | Sleep, Neuroendocrine Disorders, And the Bidirectional Relationship between the Hypothalamic-Pituitary-Adrenal Axis: A Mini-Review |
| title_full | Sleep, Neuroendocrine Disorders, And the Bidirectional Relationship between the Hypothalamic-Pituitary-Adrenal Axis: A Mini-Review |
| title_fullStr | Sleep, Neuroendocrine Disorders, And the Bidirectional Relationship between the Hypothalamic-Pituitary-Adrenal Axis: A Mini-Review |
| title_full_unstemmed | Sleep, Neuroendocrine Disorders, And the Bidirectional Relationship between the Hypothalamic-Pituitary-Adrenal Axis: A Mini-Review |
| title_short | Sleep, Neuroendocrine Disorders, And the Bidirectional Relationship between the Hypothalamic-Pituitary-Adrenal Axis: A Mini-Review |
| title_sort | sleep neuroendocrine disorders and the bidirectional relationship between the hypothalamic pituitary adrenal axis a mini review |
| topic | Sleep Apnea; Cushing's syndrome; Addison's disease; Stress Response; Hypothalamic-Pituitary-Adrenal |
| url | https://www.ajol.info/index.php/jasem/article/view/293743 |
| work_keys_str_mv | AT oaudi sleepneuroendocrinedisordersandthebidirectionalrelationshipbetweenthehypothalamicpituitaryadrenalaxisaminireview |