Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems
Pseudopolyrotaxanes (PPR) consisting of α-cyclodextrin rings and polyethylene glycol axes with end thymine groups have been synthesized and characterized successfully. Fluorescein (Fl) as a model drug was conjugated to the hydroxyl functional groups of cyclodextrin rings of PPR via ester bonds and P...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2014/829474 |
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| author | Abdolhossien Massoudi Mohsen Adeli Leila Khosravi far |
| author_facet | Abdolhossien Massoudi Mohsen Adeli Leila Khosravi far |
| author_sort | Abdolhossien Massoudi |
| collection | DOAJ |
| description | Pseudopolyrotaxanes (PPR) consisting of α-cyclodextrin rings and polyethylene glycol axes with end thymine groups have been synthesized and characterized successfully. Fluorescein (Fl) as a model drug was conjugated to the hydroxyl functional groups of cyclodextrin rings of PPR via ester bonds and PPR-Fl as the primary drug delivery system was obtained. Finally PPR-Fl was capped by hydrogen bonds between end thymine groups and a suitable complementary molecule such as polycitric acid, citric acid, or adenine. The aim of this work was to control the release of the fluorescein-cyclodextrin (Fl-CD) conjugates, as the secondary drug delivery systems, from PPR-Fl by controlling the noncovalent interactions between stoppers and thymine end groups. It was found that the rate of release of the Fl-CD from PPR-Fl could be controlled by pH and the ratio of citric acid or adenine to the PPR-Fl. |
| format | Article |
| id | doaj-art-f88c6af9119d41c2a159f3a4ac624d41 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-f88c6af9119d41c2a159f3a4ac624d412025-02-03T01:26:32ZengWileyInternational Journal of Polymer Science1687-94221687-94302014-01-01201410.1155/2014/829474829474Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery SystemsAbdolhossien Massoudi0Mohsen Adeli1Leila Khosravi far2Department of Chemistry, Payame Noor University, Tehran 19395-4697, IranDepartment of Chemistry, Lorestan University, Khoramabad, IranDepartment of Chemistry, Payame Noor University, Tehran 19395-4697, IranPseudopolyrotaxanes (PPR) consisting of α-cyclodextrin rings and polyethylene glycol axes with end thymine groups have been synthesized and characterized successfully. Fluorescein (Fl) as a model drug was conjugated to the hydroxyl functional groups of cyclodextrin rings of PPR via ester bonds and PPR-Fl as the primary drug delivery system was obtained. Finally PPR-Fl was capped by hydrogen bonds between end thymine groups and a suitable complementary molecule such as polycitric acid, citric acid, or adenine. The aim of this work was to control the release of the fluorescein-cyclodextrin (Fl-CD) conjugates, as the secondary drug delivery systems, from PPR-Fl by controlling the noncovalent interactions between stoppers and thymine end groups. It was found that the rate of release of the Fl-CD from PPR-Fl could be controlled by pH and the ratio of citric acid or adenine to the PPR-Fl.http://dx.doi.org/10.1155/2014/829474 |
| spellingShingle | Abdolhossien Massoudi Mohsen Adeli Leila Khosravi far Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems International Journal of Polymer Science |
| title | Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems |
| title_full | Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems |
| title_fullStr | Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems |
| title_full_unstemmed | Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems |
| title_short | Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems |
| title_sort | fully supramolecular polyrotaxanes as biphase drug delivery systems |
| url | http://dx.doi.org/10.1155/2014/829474 |
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