Effects Of Long-Term Use of Topical Antiglaucoma Drugs on Ocular Surface: A Cross Sectional Study
Purpose: Glaucoma is a chronic progressive disease and a major risk factor for blindness. This study aimed to evaluate the long-term effects of topical antiglaucoma drugs on ocular surface. Methods: This was a cross-sectional study, which included patients with glaucoma who had been taking one/two/t...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Delhi Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.7869/djo.740 |
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| Summary: | Purpose:
Glaucoma is a chronic progressive disease and a major risk factor for blindness. This study aimed to evaluate the long-term effects of topical antiglaucoma drugs on ocular surface.
Methods:
This was a cross-sectional study, which included patients with glaucoma who had been taking one/two/three topical drugs (minimum 3 months) and control group of newly diagnosed glaucoma (10 months). The patients were divided into test groups A1 (timolol 0.5%/ briminodine 0.1%/ bimatoprost 0.01%), A2 (dual combination of any of the above drugs), A3 (triple combination) and control. Schirmer-I, tear film breakup time (TBUT), rose bengal, conjunctival impression cytology and ocular surface disease index (OSDI) scores were evaluated.
Results:
A total of 164 patients were enrolled and divided into groups A1, A2, A3 and control, respectively. There was a significant difference in Schirmer’s test (mm) results between the groups (15.06, 13.77, 11.24 and 21.26 in A1, A2, A3 and control, respectively; p<0.001). The mean TBUT (seconds) was 9.84, 8.25, 5.29 and 12.33 in A1, A2, A3 in control group, respectively (p<0.001 timolol 0.5% plus briminodine 0.1% plus bimatoprost 0.01%). Abnormal rose bengal was higher in A2 and A3 than A1 (3.94, 5.92 and 2.55, respectively; p<0.001). The mean conjunctival impression cytology grades were more severe in subgroups A1 (1.83), A2 (1.70) and A3 (2.74) than control group (0.96). The mean OSDI scores were significantly (p<0.001) higher in A2 (34.62) and A3 (49.63) than A1 (25.93).
Conclusion:
Topical antiglaucoma drugs caused OSD on long term use. The severity of OSD was higher in multiple drug combinations in comparison to single drug. |
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| ISSN: | 0972-0200 2454-2784 |