Design, optimization, and validation of a magnetic mother-child robot system for targeted drug delivery
Traditional untethered magnetic microrobots utilized for in vivo targeted drug delivery face challenges related to poor maneuverability and limited kinematic performance. In this study, we harness the strengths of both magnetic continuum robots (acting as “mother” units) and untethered microrobots (...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127525002473 |
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| author | Bentao Zou Huibin Liu Xuehao Fen Zhizheng Gao Zhixing Ge Wenguang Yang |
| author_facet | Bentao Zou Huibin Liu Xuehao Fen Zhizheng Gao Zhixing Ge Wenguang Yang |
| author_sort | Bentao Zou |
| collection | DOAJ |
| description | Traditional untethered magnetic microrobots utilized for in vivo targeted drug delivery face challenges related to poor maneuverability and limited kinematic performance. In this study, we harness the strengths of both magnetic continuum robots (acting as “mother” units) and untethered microrobots (functioning as “child” units), refining the motion model to develop a magnetically driven mother–child robotic system. We have also enhanced the structural design of the magnetic continuum and optimized the batch fabrication process of pH-responsive hydrogel integrated with the microrobots. This design allows the child robots to be deployed by the mother unit and subsequently retrieved upon task completion. Our strategy, which aims to minimize foreign body presence and reduce side effects, was validated using an in vitro gastric model, demonstrating the feasibility and enhanced operability of this system. |
| format | Article |
| id | doaj-art-f870de7bdb8f42e89b540bc4f9e48436 |
| institution | OA Journals |
| issn | 0264-1275 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj-art-f870de7bdb8f42e89b540bc4f9e484362025-08-20T02:00:50ZengElsevierMaterials & Design0264-12752025-05-0125311382710.1016/j.matdes.2025.113827Design, optimization, and validation of a magnetic mother-child robot system for targeted drug deliveryBentao Zou0Huibin Liu1Xuehao Fen2Zhizheng Gao3Zhixing Ge4Wenguang Yang5Engineering Training Center, Yantai University, Yantai 264005, ChinaSchool of Electromechanical and Automotive Engineering, Yantai University, Yantai 264005, ChinaSchool of Electromechanical and Automotive Engineering, Yantai University, Yantai 264005, ChinaSchool of Electromechanical and Automotive Engineering, Yantai University, Yantai 264005, ChinaDepartment of Biomedical Engineering, National University of Singapore, 119077, SingaporeSchool of Electromechanical and Automotive Engineering, Yantai University, Yantai 264005, China; Corresponding author.Traditional untethered magnetic microrobots utilized for in vivo targeted drug delivery face challenges related to poor maneuverability and limited kinematic performance. In this study, we harness the strengths of both magnetic continuum robots (acting as “mother” units) and untethered microrobots (functioning as “child” units), refining the motion model to develop a magnetically driven mother–child robotic system. We have also enhanced the structural design of the magnetic continuum and optimized the batch fabrication process of pH-responsive hydrogel integrated with the microrobots. This design allows the child robots to be deployed by the mother unit and subsequently retrieved upon task completion. Our strategy, which aims to minimize foreign body presence and reduce side effects, was validated using an in vitro gastric model, demonstrating the feasibility and enhanced operability of this system.http://www.sciencedirect.com/science/article/pii/S0264127525002473Mother-child type robotpH responseMagneticallyTargeted drug delivery |
| spellingShingle | Bentao Zou Huibin Liu Xuehao Fen Zhizheng Gao Zhixing Ge Wenguang Yang Design, optimization, and validation of a magnetic mother-child robot system for targeted drug delivery Materials & Design Mother-child type robot pH response Magnetically Targeted drug delivery |
| title | Design, optimization, and validation of a magnetic mother-child robot system for targeted drug delivery |
| title_full | Design, optimization, and validation of a magnetic mother-child robot system for targeted drug delivery |
| title_fullStr | Design, optimization, and validation of a magnetic mother-child robot system for targeted drug delivery |
| title_full_unstemmed | Design, optimization, and validation of a magnetic mother-child robot system for targeted drug delivery |
| title_short | Design, optimization, and validation of a magnetic mother-child robot system for targeted drug delivery |
| title_sort | design optimization and validation of a magnetic mother child robot system for targeted drug delivery |
| topic | Mother-child type robot pH response Magnetically Targeted drug delivery |
| url | http://www.sciencedirect.com/science/article/pii/S0264127525002473 |
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