Photothermal-enhanced silver nanocluster bioactive glass hydrogels for synergistic antimicrobial and promote wound healing

Antibacterial hydrogels are promising for combating infections and promoting wound healing. Nevertheless, excessive antibiotics induce resistance, and high metal ion levels cause cytotoxicity, complicating healing. Here, we introduce a hydrogel incorporating polydopamine-coated bioactive glass (BGs@...

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Main Authors: Fuqiang Song, Anqi Ye, Linyuan Jiang, Yang Lu, Yanzhen Feng, Rong Huang, Siting Du, Xiaoyu Dong, Ting Huang, Ping Li, Liangliang Yang, Jinjing Zhang, Mengjia Xu, Li Cheng, Jian Xiao
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Language:English
Published: Elsevier 2025-02-01
Series:Materials Today Bio
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Online Access:http://www.sciencedirect.com/science/article/pii/S2590006424005003
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author Fuqiang Song
Anqi Ye
Linyuan Jiang
Yang Lu
Yanzhen Feng
Rong Huang
Siting Du
Xiaoyu Dong
Ting Huang
Ping Li
Liangliang Yang
Jinjing Zhang
Mengjia Xu
Li Cheng
Jian Xiao
author_facet Fuqiang Song
Anqi Ye
Linyuan Jiang
Yang Lu
Yanzhen Feng
Rong Huang
Siting Du
Xiaoyu Dong
Ting Huang
Ping Li
Liangliang Yang
Jinjing Zhang
Mengjia Xu
Li Cheng
Jian Xiao
author_sort Fuqiang Song
collection DOAJ
description Antibacterial hydrogels are promising for combating infections and promoting wound healing. Nevertheless, excessive antibiotics induce resistance, and high metal ion levels cause cytotoxicity, complicating healing. Here, we introduce a hydrogel incorporating polydopamine-coated bioactive glass (BGs@PDA) on reduced graphene oxide (rGO) with photothermal therapy (PTT) and silver nanoclusters (AgNCs) for synergistic antibacterial treatment. This design enables rapid bacterial eradication and controlled release. Near-infrared-assisted heating provides noninvasive, targeted hyperthermia, killing bacteria quickly. Post-PTT addition of low-dose AgNCs reduces toxicity while enhancing antimicrobial efficacy and biocompatibility. BGs@PDA-loaded rGO prevents sedimentation, improves photothermal conversion and conductivity, and stabilizes the hydrogel structure. Constructed from chitosan and hydroxyethyl cellulose, the hydrogel is cross-linked by PDA and rGO, enhancing mechanical strength, adhesion, self-healing, free radical scavenging, and continuous wound exudate absorption. PDA encapsulation facilitates BGs degradation, improving the wound microenvironment. In vivo studies confirm accelerated healing and potent synergistic antibacterial effects, indicating its potential as a low-dose, antibiotic-free alternative for clinical wound infection management.
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spelling doaj-art-f86dcae8030244d586cf50d72178d92c2025-01-17T04:52:14ZengElsevierMaterials Today Bio2590-00642025-02-0130101439Photothermal-enhanced silver nanocluster bioactive glass hydrogels for synergistic antimicrobial and promote wound healingFuqiang Song0Anqi Ye1Linyuan Jiang2Yang Lu3Yanzhen Feng4Rong Huang5Siting Du6Xiaoyu Dong7Ting Huang8Ping Li9Liangliang Yang10Jinjing Zhang11Mengjia Xu12Li Cheng13Jian Xiao14Affiliated Cixi Hospital, Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300, China; Department of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, ChinaAffiliated Cixi Hospital, Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300, China; Department of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, ChinaAffiliated Cixi Hospital, Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300, China; Department of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, ChinaDepartment of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, ChinaDepartment of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, ChinaAffiliated Cixi Hospital, Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300, China; Department of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, ChinaDepartment of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, ChinaDepartment of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, ChinaDepartment of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, ChinaDepartment of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, ChinaAffiliated Cixi Hospital, Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, ChinaAffiliated Cixi Hospital, Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300, China; Corresponding author. Affiliated Cixi Hospital, Wenzhou Medical University, Cixi, 315300, China.Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Zhejiang International Cooperation Base of Biomedical Materials Technology and Application, Ningbo Cixi Institute of Biomedical Engineering, Laboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China; Corresponding author. Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Zhejiang International Cooperation Base of Biomedical Materials Technology and Application, Ningbo Cixi Institute of Biomedical Engineering, Laboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.Affiliated Cixi Hospital, Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300, China; Corresponding author. Affiliated Cixi Hospital, Wenzhou Medical University, Cixi, 315300, China.Department of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China; Corresponding author. Affiliated Cixi Hospital, Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300, China.Antibacterial hydrogels are promising for combating infections and promoting wound healing. Nevertheless, excessive antibiotics induce resistance, and high metal ion levels cause cytotoxicity, complicating healing. Here, we introduce a hydrogel incorporating polydopamine-coated bioactive glass (BGs@PDA) on reduced graphene oxide (rGO) with photothermal therapy (PTT) and silver nanoclusters (AgNCs) for synergistic antibacterial treatment. This design enables rapid bacterial eradication and controlled release. Near-infrared-assisted heating provides noninvasive, targeted hyperthermia, killing bacteria quickly. Post-PTT addition of low-dose AgNCs reduces toxicity while enhancing antimicrobial efficacy and biocompatibility. BGs@PDA-loaded rGO prevents sedimentation, improves photothermal conversion and conductivity, and stabilizes the hydrogel structure. Constructed from chitosan and hydroxyethyl cellulose, the hydrogel is cross-linked by PDA and rGO, enhancing mechanical strength, adhesion, self-healing, free radical scavenging, and continuous wound exudate absorption. PDA encapsulation facilitates BGs degradation, improving the wound microenvironment. In vivo studies confirm accelerated healing and potent synergistic antibacterial effects, indicating its potential as a low-dose, antibiotic-free alternative for clinical wound infection management.http://www.sciencedirect.com/science/article/pii/S2590006424005003Photothermal antibacterialSilver nanohybridsAntibacterial hydrogelsPolydopamine-coated bioactive glassWound healing
spellingShingle Fuqiang Song
Anqi Ye
Linyuan Jiang
Yang Lu
Yanzhen Feng
Rong Huang
Siting Du
Xiaoyu Dong
Ting Huang
Ping Li
Liangliang Yang
Jinjing Zhang
Mengjia Xu
Li Cheng
Jian Xiao
Photothermal-enhanced silver nanocluster bioactive glass hydrogels for synergistic antimicrobial and promote wound healing
Materials Today Bio
Photothermal antibacterial
Silver nanohybrids
Antibacterial hydrogels
Polydopamine-coated bioactive glass
Wound healing
title Photothermal-enhanced silver nanocluster bioactive glass hydrogels for synergistic antimicrobial and promote wound healing
title_full Photothermal-enhanced silver nanocluster bioactive glass hydrogels for synergistic antimicrobial and promote wound healing
title_fullStr Photothermal-enhanced silver nanocluster bioactive glass hydrogels for synergistic antimicrobial and promote wound healing
title_full_unstemmed Photothermal-enhanced silver nanocluster bioactive glass hydrogels for synergistic antimicrobial and promote wound healing
title_short Photothermal-enhanced silver nanocluster bioactive glass hydrogels for synergistic antimicrobial and promote wound healing
title_sort photothermal enhanced silver nanocluster bioactive glass hydrogels for synergistic antimicrobial and promote wound healing
topic Photothermal antibacterial
Silver nanohybrids
Antibacterial hydrogels
Polydopamine-coated bioactive glass
Wound healing
url http://www.sciencedirect.com/science/article/pii/S2590006424005003
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