Bibliometric Analysis of Neuroinflammation and Postoperative Cognitive Dysfunction
ABSTRACT Background The occurrence and development of postoperative cognitive dysfunction (POCD) are closely linked to neuroinflammation. This bibliometric analysis aims to provide novel insights into the research trajectory, key research topics, and potential future development trends in the field...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70271 |
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| author | Zheping Chen Zhenxiang Zuo Yizheng Zhang Guoliang Shan Le Zhang Moxuan Gong Yuyang Ye Yufeng Ma Yanwu Jin |
| author_facet | Zheping Chen Zhenxiang Zuo Yizheng Zhang Guoliang Shan Le Zhang Moxuan Gong Yuyang Ye Yufeng Ma Yanwu Jin |
| author_sort | Zheping Chen |
| collection | DOAJ |
| description | ABSTRACT Background The occurrence and development of postoperative cognitive dysfunction (POCD) are closely linked to neuroinflammation. This bibliometric analysis aims to provide novel insights into the research trajectory, key research topics, and potential future development trends in the field of neuroinflammation‐induced POCD. Methods The Web of Science Core Collection (WoSCC) database was searched to identify publications from 2012 to 2023 on neuroinflammation‐induced POCD. Bibliometric analysis, involving both statistical and visual analyses, was conducted using CiteSpace, VOSviewer, and the R software. Results Research on neuroinflammation‐induced POCD has exhibited an increasing trend over the past 12 years. China had the highest number of publications, Nanjing Medical University had the most collaboration with other institutions, Zhiyi Zuo was the most published author, and the Journal of Neuroinflammation served as the primary publication in the field of neuroinflammation‐induced POCD. The most frequent keyword was POCD. Keyword clustering analysis indicated that the predominant cluster is dexmedetomidine. Burst detection revealed that postoperative delirium (POD), perioperative neurocognitive disorders (PND), apoptosis, and epigenetic modifications were the future research trends. Conclusions Our analysis identified the following key research areas associated with neuroinflammation‐induced POCD: anesthesia, surgery, dexmedetomidine, NLRP3 inflammasome, and mechanism of neuroinflammation‐induced POCD. The potential future research topics comprise POD, PND, apoptosis, and epigenetic modifications. |
| format | Article |
| id | doaj-art-f86c2901f0844bc09f238d837f3fb462 |
| institution | Kabale University |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-f86c2901f0844bc09f238d837f3fb4622025-01-29T13:36:40ZengWileyBrain and Behavior2162-32792025-01-01151n/an/a10.1002/brb3.70271Bibliometric Analysis of Neuroinflammation and Postoperative Cognitive DysfunctionZheping Chen0Zhenxiang Zuo1Yizheng Zhang2Guoliang Shan3Le Zhang4Moxuan Gong5Yuyang Ye6Yufeng Ma7Yanwu Jin8Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain‐Like Intelligence, Clinical Research Center for Anesthesiology and Perioperative Medicine, Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, School of Medicine Tongji University Shanghai People's Republic of ChinaDepartment of Gastroenterology, the Second Hospital, Cheeloo College of Medicine Shandong University Jinan People's Republic of ChinaDepartment of Anesthesiology, the Second Hospital, Cheeloo College of Medicine Shandong University Jinan People's Republic of ChinaDepartment of Anesthesiology, the Second Hospital, Cheeloo College of Medicine Shandong University Jinan People's Republic of ChinaDepartment of Anesthesiology, the Second Hospital, Cheeloo College of Medicine Shandong University Jinan People's Republic of ChinaDepartment of Anesthesiology, the Second Hospital, Cheeloo College of Medicine Shandong University Jinan People's Republic of ChinaDepartment of Anesthesiology, the Second Hospital, Cheeloo College of Medicine Shandong University Jinan People's Republic of ChinaDepartment of Anesthesiology, the Second Hospital, Cheeloo College of Medicine Shandong University Jinan People's Republic of ChinaDepartment of Anesthesiology, the Second Hospital, Cheeloo College of Medicine Shandong University Jinan People's Republic of ChinaABSTRACT Background The occurrence and development of postoperative cognitive dysfunction (POCD) are closely linked to neuroinflammation. This bibliometric analysis aims to provide novel insights into the research trajectory, key research topics, and potential future development trends in the field of neuroinflammation‐induced POCD. Methods The Web of Science Core Collection (WoSCC) database was searched to identify publications from 2012 to 2023 on neuroinflammation‐induced POCD. Bibliometric analysis, involving both statistical and visual analyses, was conducted using CiteSpace, VOSviewer, and the R software. Results Research on neuroinflammation‐induced POCD has exhibited an increasing trend over the past 12 years. China had the highest number of publications, Nanjing Medical University had the most collaboration with other institutions, Zhiyi Zuo was the most published author, and the Journal of Neuroinflammation served as the primary publication in the field of neuroinflammation‐induced POCD. The most frequent keyword was POCD. Keyword clustering analysis indicated that the predominant cluster is dexmedetomidine. Burst detection revealed that postoperative delirium (POD), perioperative neurocognitive disorders (PND), apoptosis, and epigenetic modifications were the future research trends. Conclusions Our analysis identified the following key research areas associated with neuroinflammation‐induced POCD: anesthesia, surgery, dexmedetomidine, NLRP3 inflammasome, and mechanism of neuroinflammation‐induced POCD. The potential future research topics comprise POD, PND, apoptosis, and epigenetic modifications.https://doi.org/10.1002/brb3.70271postoperative cognitive dysfunctionneuroinflammationpostoperative deliriumperioperative neurocognitive disordersepigenetic modifications |
| spellingShingle | Zheping Chen Zhenxiang Zuo Yizheng Zhang Guoliang Shan Le Zhang Moxuan Gong Yuyang Ye Yufeng Ma Yanwu Jin Bibliometric Analysis of Neuroinflammation and Postoperative Cognitive Dysfunction Brain and Behavior postoperative cognitive dysfunction neuroinflammation postoperative delirium perioperative neurocognitive disorders epigenetic modifications |
| title | Bibliometric Analysis of Neuroinflammation and Postoperative Cognitive Dysfunction |
| title_full | Bibliometric Analysis of Neuroinflammation and Postoperative Cognitive Dysfunction |
| title_fullStr | Bibliometric Analysis of Neuroinflammation and Postoperative Cognitive Dysfunction |
| title_full_unstemmed | Bibliometric Analysis of Neuroinflammation and Postoperative Cognitive Dysfunction |
| title_short | Bibliometric Analysis of Neuroinflammation and Postoperative Cognitive Dysfunction |
| title_sort | bibliometric analysis of neuroinflammation and postoperative cognitive dysfunction |
| topic | postoperative cognitive dysfunction neuroinflammation postoperative delirium perioperative neurocognitive disorders epigenetic modifications |
| url | https://doi.org/10.1002/brb3.70271 |
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