Combinatorial mathematical modelling approaches to interrogate rear retraction dynamics in 3D cell migration.

Cell migration in 3D microenvironments is a complex process which depends on the coordinated activity of leading edge protrusive force and rear retraction in a push-pull mechanism. While the potentiation of protrusions has been widely studied, the precise signalling and mechanical events that lead t...

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Bibliographic Details
Main Authors: Joseph H R Hetmanski, Matthew C Jones, Fatima Chunara, Jean-Marc Schwartz, Patrick T Caswell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-03-01
Series:PLoS Computational Biology
Online Access:https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008213&type=printable
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