GluN2B-mediated regulation of silent synapses for receptor specification and addiction memory

GluN2B-mediated regulation of silent synapses for receptor specification and addiction memory

Abstract Psychostimulants, including cocaine, elicit stereotyped, addictive behaviors. The reemergence of silent synapses containing only NMDA-type glutamate receptors is a critical mediator of addiction memory and seeking behaviors. Despite the predominant abundance of GluN2B-containing NMDA-type g...

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Main Authors: Hyun Jin Kim, Sangjun Lee, Gyu Hyun Kim, Kibong Sung, Taesik Yoo, Jung Hyun Pyo, Hee-Jung Jo, Sanghyeon Lee, Hyun-Young Lee, Jung Hoon Jung, Kea Joo Lee, Joung-Hun Kim
Format: Article
Language:English
Published: Nature Publishing Group 2025-02-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-025-01399-z
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