TWEAK/Fn14 Drives Tumor Progression and Is Associated With Poor Survival of Colorectal Liver Metastases With Replacement Growth Patterns

TWEAK/Fn14 Drives Tumor Progression and Is Associated With Poor Survival of Colorectal Liver Metastases With Replacement Growth Patterns

ABSTRACT Objective Colorectal liver metastases (CRLMs) with replacement growth pattern (rHGP) are associated with a poor prognosis; however, the underlying mechanisms driving rHGP remain poorly understood. This study investigated the effect of the TWEAK/Fn14 axis in CRLMs on tumor progression to exp...

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Main Authors: Naoki Matsuyama, Takanori Konishi, Tsukasa Takayashiki, Shigetsugu Takano, Daisuke Suzuki, Nozomu Sakai, Isamu Hosokawa, Takashi Mishima, Kensuke Suzuki, Hitoe Nishino, Shinichiro Nakada, Masayuki Ohtsuka
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Cancer Medicine
Subjects:
colorectal liver metastases
Fn14
histopathological growth pattern
TWEAK
Online Access:https://doi.org/10.1002/cam4.71027
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