The Prognostic Significance of Tumor Deposit Count for Colorectal Cancer Patients after Radical Surgery
Background. The prognostic value of tumor deposit (TD) count in colorectal cancer (CRC) patients has been rarely evaluated. This study is aimed at exploring the prognostic value of TD count and finding out the optimal cutoff point of TD count to differentiate the prognoses of TD-positive CRC patient...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/2052561 |
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| _version_ | 1849468106890543104 |
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| author | Kuo Zheng Nanxin Zheng Cheng Xin Leqi Zhou Ge Sun Rongbo Wen Hang Zhang Guanyu Yu Chenguang Bai Wei Zhang |
| author_facet | Kuo Zheng Nanxin Zheng Cheng Xin Leqi Zhou Ge Sun Rongbo Wen Hang Zhang Guanyu Yu Chenguang Bai Wei Zhang |
| author_sort | Kuo Zheng |
| collection | DOAJ |
| description | Background. The prognostic value of tumor deposit (TD) count in colorectal cancer (CRC) patients has been rarely evaluated. This study is aimed at exploring the prognostic value of TD count and finding out the optimal cutoff point of TD count to differentiate the prognoses of TD-positive CRC patients. Method. Patients diagnosed with CRC from Surveillance, Epidemiology, and End Results (SEER) database from January 1, 2010, to December 31, 2012, were analyzed. X-tile program was used to identify the optimal cutoff point of TD count in training cohort, and a validation cohort was used to test this cutoff point after propensity score matching (PSM). Univariate and multivariate Cox proportional hazard models were used to assess the risk factors of survival. Results. X-tile plots identified 3 (P<0.001) as the optimal cutoff point of TD count to divide the patients of training cohort into high and low risk subsets in terms of disease-specific survival (DSS). This cutoff point was validated in validation cohort before and after PSM (P<0.001, P=0.002). More TD count, which was defined as more than 3, was validated as an independent risk prognostic factor in univariate and multivariate analysis (P<0.001). Conclusion. More TD count (TD count≥4) was significantly associated with poor disease-specific survival in CRC patients. |
| format | Article |
| id | doaj-art-f851a1a360b245a5b5149d949c624a4d |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-f851a1a360b245a5b5149d949c624a4d2025-08-20T03:25:56ZengWileyGastroenterology Research and Practice1687-61211687-630X2020-01-01202010.1155/2020/20525612052561The Prognostic Significance of Tumor Deposit Count for Colorectal Cancer Patients after Radical SurgeryKuo Zheng0Nanxin Zheng1Cheng Xin2Leqi Zhou3Ge Sun4Rongbo Wen5Hang Zhang6Guanyu Yu7Chenguang Bai8Wei Zhang9Department of Colorectal Surgery, Changhai Hospital, Shanghai, ChinaDepartment of Colorectal Surgery, Changhai Hospital, Shanghai, ChinaDepartment of Colorectal Surgery, Changhai Hospital, Shanghai, ChinaDepartment of Colorectal Surgery, Changhai Hospital, Shanghai, ChinaDepartment of Colorectal Surgery, Changhai Hospital, Shanghai, ChinaDepartment of Colorectal Surgery, Changhai Hospital, Shanghai, ChinaDepartment of Colorectal Surgery, Changhai Hospital, Shanghai, ChinaDepartment of Colorectal Surgery, Changhai Hospital, Shanghai, ChinaDepartment of Pathology, Changhai Hospital, Shanghai, ChinaDepartment of Colorectal Surgery, Changhai Hospital, Shanghai, ChinaBackground. The prognostic value of tumor deposit (TD) count in colorectal cancer (CRC) patients has been rarely evaluated. This study is aimed at exploring the prognostic value of TD count and finding out the optimal cutoff point of TD count to differentiate the prognoses of TD-positive CRC patients. Method. Patients diagnosed with CRC from Surveillance, Epidemiology, and End Results (SEER) database from January 1, 2010, to December 31, 2012, were analyzed. X-tile program was used to identify the optimal cutoff point of TD count in training cohort, and a validation cohort was used to test this cutoff point after propensity score matching (PSM). Univariate and multivariate Cox proportional hazard models were used to assess the risk factors of survival. Results. X-tile plots identified 3 (P<0.001) as the optimal cutoff point of TD count to divide the patients of training cohort into high and low risk subsets in terms of disease-specific survival (DSS). This cutoff point was validated in validation cohort before and after PSM (P<0.001, P=0.002). More TD count, which was defined as more than 3, was validated as an independent risk prognostic factor in univariate and multivariate analysis (P<0.001). Conclusion. More TD count (TD count≥4) was significantly associated with poor disease-specific survival in CRC patients.http://dx.doi.org/10.1155/2020/2052561 |
| spellingShingle | Kuo Zheng Nanxin Zheng Cheng Xin Leqi Zhou Ge Sun Rongbo Wen Hang Zhang Guanyu Yu Chenguang Bai Wei Zhang The Prognostic Significance of Tumor Deposit Count for Colorectal Cancer Patients after Radical Surgery Gastroenterology Research and Practice |
| title | The Prognostic Significance of Tumor Deposit Count for Colorectal Cancer Patients after Radical Surgery |
| title_full | The Prognostic Significance of Tumor Deposit Count for Colorectal Cancer Patients after Radical Surgery |
| title_fullStr | The Prognostic Significance of Tumor Deposit Count for Colorectal Cancer Patients after Radical Surgery |
| title_full_unstemmed | The Prognostic Significance of Tumor Deposit Count for Colorectal Cancer Patients after Radical Surgery |
| title_short | The Prognostic Significance of Tumor Deposit Count for Colorectal Cancer Patients after Radical Surgery |
| title_sort | prognostic significance of tumor deposit count for colorectal cancer patients after radical surgery |
| url | http://dx.doi.org/10.1155/2020/2052561 |
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