Neurophysiological gradient in the Parkinsonian subthalamic nucleus as a marker for motor symptoms and apathy
Abstract Sensing-based deep brain stimulation should optimally consider both the motor and neuropsychiatric domain to maximize quality of life of Parkinson’s disease (PD) patients. Here we characterize the neurophysiological properties of the subthalamic nucleus (STN) in 69 PD patients using a newly...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-024-00848-2 |
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| author | Elena Bernasconi Deborah Amstutz Alberto Averna Petra Fischer Mario Sousa Ines Debove Katrin Petermann Laura Alva Andreia D. Magalhães M. Lenard Lachenmayer Thuy-Anh K. Nguyen Michael Schuepbach Andreas Nowacki Claudio Pollo Paul Krack Gerd Tinkhauser |
| author_facet | Elena Bernasconi Deborah Amstutz Alberto Averna Petra Fischer Mario Sousa Ines Debove Katrin Petermann Laura Alva Andreia D. Magalhães M. Lenard Lachenmayer Thuy-Anh K. Nguyen Michael Schuepbach Andreas Nowacki Claudio Pollo Paul Krack Gerd Tinkhauser |
| author_sort | Elena Bernasconi |
| collection | DOAJ |
| description | Abstract Sensing-based deep brain stimulation should optimally consider both the motor and neuropsychiatric domain to maximize quality of life of Parkinson’s disease (PD) patients. Here we characterize the neurophysiological properties of the subthalamic nucleus (STN) in 69 PD patients using a newly established neurophysiological gradient metric and contextualize it with motor symptoms and apathy. We could evidence a STN power gradient that holds most of the spectral information between 5 and 30 Hz spanning along the dorsal-ventral axis. It shows elevated power in the sub-beta range (8-12 Hz) toward the ventral STN, and elevated dorsal beta power (16–24 Hz) indicative for the hemispheres contralateral to the more affected hemi-body side. The rigidity response to DBS was highest dorsally on the axis. Importantly, apathetic symptoms can be related to reduced ventral alpha power. In conclusion, the STN spectral gradient may inform about the motor and neuropsychiatric domain, supporting integrative closed-loop strategies. |
| format | Article |
| id | doaj-art-f84465ed103b4608b173138a1fdbfdd9 |
| institution | Kabale University |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-f84465ed103b4608b173138a1fdbfdd92025-01-05T12:12:01ZengNature Portfolionpj Parkinson's Disease2373-80572025-01-0111111110.1038/s41531-024-00848-2Neurophysiological gradient in the Parkinsonian subthalamic nucleus as a marker for motor symptoms and apathyElena Bernasconi0Deborah Amstutz1Alberto Averna2Petra Fischer3Mario Sousa4Ines Debove5Katrin Petermann6Laura Alva7Andreia D. Magalhães8M. Lenard Lachenmayer9Thuy-Anh K. Nguyen10Michael Schuepbach11Andreas Nowacki12Claudio Pollo13Paul Krack14Gerd Tinkhauser15Department of Neurology, Bern University Hospital and University of BernDepartment of Neurology, Bern University Hospital and University of BernDepartment of Neurology, Bern University Hospital and University of BernSchool of Physiology, Pharmacology & Neuroscience, University of Bristol, University WalkDepartment of Neurology, Bern University Hospital and University of BernDepartment of Neurology, Bern University Hospital and University of BernDepartment of Neurology, Bern University Hospital and University of BernDepartment of Neurology, Bern University Hospital and University of BernDepartment of Neurology, Bern University Hospital and University of BernDepartment of Neurology, Bern University Hospital and University of BernDepartment of Neurosurgery, Bern University Hospital and University of BernInstitute of NeurologyDepartment of Neurosurgery, Bern University Hospital and University of BernDepartment of Neurosurgery, Bern University Hospital and University of BernDepartment of Neurology, Bern University Hospital and University of BernDepartment of Neurology, Bern University Hospital and University of BernAbstract Sensing-based deep brain stimulation should optimally consider both the motor and neuropsychiatric domain to maximize quality of life of Parkinson’s disease (PD) patients. Here we characterize the neurophysiological properties of the subthalamic nucleus (STN) in 69 PD patients using a newly established neurophysiological gradient metric and contextualize it with motor symptoms and apathy. We could evidence a STN power gradient that holds most of the spectral information between 5 and 30 Hz spanning along the dorsal-ventral axis. It shows elevated power in the sub-beta range (8-12 Hz) toward the ventral STN, and elevated dorsal beta power (16–24 Hz) indicative for the hemispheres contralateral to the more affected hemi-body side. The rigidity response to DBS was highest dorsally on the axis. Importantly, apathetic symptoms can be related to reduced ventral alpha power. In conclusion, the STN spectral gradient may inform about the motor and neuropsychiatric domain, supporting integrative closed-loop strategies.https://doi.org/10.1038/s41531-024-00848-2 |
| spellingShingle | Elena Bernasconi Deborah Amstutz Alberto Averna Petra Fischer Mario Sousa Ines Debove Katrin Petermann Laura Alva Andreia D. Magalhães M. Lenard Lachenmayer Thuy-Anh K. Nguyen Michael Schuepbach Andreas Nowacki Claudio Pollo Paul Krack Gerd Tinkhauser Neurophysiological gradient in the Parkinsonian subthalamic nucleus as a marker for motor symptoms and apathy npj Parkinson's Disease |
| title | Neurophysiological gradient in the Parkinsonian subthalamic nucleus as a marker for motor symptoms and apathy |
| title_full | Neurophysiological gradient in the Parkinsonian subthalamic nucleus as a marker for motor symptoms and apathy |
| title_fullStr | Neurophysiological gradient in the Parkinsonian subthalamic nucleus as a marker for motor symptoms and apathy |
| title_full_unstemmed | Neurophysiological gradient in the Parkinsonian subthalamic nucleus as a marker for motor symptoms and apathy |
| title_short | Neurophysiological gradient in the Parkinsonian subthalamic nucleus as a marker for motor symptoms and apathy |
| title_sort | neurophysiological gradient in the parkinsonian subthalamic nucleus as a marker for motor symptoms and apathy |
| url | https://doi.org/10.1038/s41531-024-00848-2 |
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