Retrospective analysis of primary pulmonary lymphoma cases from Polish Lymphoma Research Group centers reveals associations between initial symptoms and outcomes
Abstract Primary pulmonary lymphoma (PPL) is a rare extranodal lymphoma, accounting for only 0.4% of all lymphomas. We conducted a retrospective analysis of 78 patients with PPL treated at 15 tertiary care hematooncology centers in Poland. The study revealed a high incidence of aggressive B-cell lym...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-12469-7 |
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| author | Agnieszka Giza Paulina Dumnicka Elżbieta Kalicińska Joanna Romejko-Jarosińska Joanna Drozd-Sokołowska Aleksander Kania Dagmara Zimowska-Curyło Wanda Knopińska-Posłuszny Grażyna Siewior Renata Guzicka-Kazimierczak Magdalena Witkowska Marta Morawska Paweł Kurczab Ewa Kalinka Marta Handzlik Dariusz Giza Ewa Paszkiewicz-Kozik Sebastian Giebel Jan Maciej Zaucha Tomasz Wróbel |
| author_facet | Agnieszka Giza Paulina Dumnicka Elżbieta Kalicińska Joanna Romejko-Jarosińska Joanna Drozd-Sokołowska Aleksander Kania Dagmara Zimowska-Curyło Wanda Knopińska-Posłuszny Grażyna Siewior Renata Guzicka-Kazimierczak Magdalena Witkowska Marta Morawska Paweł Kurczab Ewa Kalinka Marta Handzlik Dariusz Giza Ewa Paszkiewicz-Kozik Sebastian Giebel Jan Maciej Zaucha Tomasz Wróbel |
| author_sort | Agnieszka Giza |
| collection | DOAJ |
| description | Abstract Primary pulmonary lymphoma (PPL) is a rare extranodal lymphoma, accounting for only 0.4% of all lymphomas. We conducted a retrospective analysis of 78 patients with PPL treated at 15 tertiary care hematooncology centers in Poland. The study revealed a high incidence of aggressive B-cell lymphoma (42%), although this may reflect the specificity of participating centers. A high prevalence of pleural effusion and dyspnea at the time of diagnosis was found to be associated with worse overall survival in all PPL patients. Dyspnea and bilateral lung lesions at presentation were associated with a lack of complete remission, while the presence of cough was associated with shorter time to disease progression or relapse. Although the progression-free survival did not differ significantly between patients with low- versus high-grade B-cell PPLs, those with indolent PPLs exhibited superior overall survival. To the best of our knowledge, this study is the first multicenter retrospective analysis of PPL in Central Europe involving such a large cohort of patients. |
| format | Article |
| id | doaj-art-f83cdda8a6044e9eb6bc150dc652bf53 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-f83cdda8a6044e9eb6bc150dc652bf532025-08-20T03:46:03ZengNature PortfolioScientific Reports2045-23222025-07-0115111110.1038/s41598-025-12469-7Retrospective analysis of primary pulmonary lymphoma cases from Polish Lymphoma Research Group centers reveals associations between initial symptoms and outcomesAgnieszka Giza0Paulina Dumnicka1Elżbieta Kalicińska2Joanna Romejko-Jarosińska3Joanna Drozd-Sokołowska4Aleksander Kania5Dagmara Zimowska-Curyło6Wanda Knopińska-Posłuszny7Grażyna Siewior8Renata Guzicka-Kazimierczak9Magdalena Witkowska10Marta Morawska11Paweł Kurczab12Ewa Kalinka13Marta Handzlik14Dariusz Giza15Ewa Paszkiewicz-Kozik16Sebastian Giebel17Jan Maciej Zaucha18Tomasz Wróbel19Department of Hematology, Jagiellonian University Medical College, Faculty of MedicineChair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University Medical CollegeDepartament of Hematology, Cellular Therapies and Internal Medicine, Medical University, WroclawDepartment of Lymphoid Malignancies, Maria Sklodowska-Curie National Research Institute of OncologyDepartment of Hematology, Transplantation and Internal Medicine, University Clinical Centre, Medical University of Warsaw2nd Department of Medicine, Department of Pulmonology Jagiellonian University Medical College, Faculty of MedicineDepartment of Hematology, Jagiellonian University Medical College, Faculty of MedicineDepartment of Hematology and Bone Marrow Transplantation, Maritime HospitalInternal Medicine and Oncology Department, Medical University of SilesiaDepartment Hematology and Transplantology, Pomeranian Medical UniversityDepartment of Hematology, Medical University of LodzExperimental Hematooncology Department, Medical University of LublinMrukmed Medical Center with Outpatient Chemotherapy UnitDepartment of Oncology, Polish Mother’s Memorial Hospital-Research Institute in LodzBeskid Oncology Center - City Hospital in Bielsko-BiałaDepartment of Nephrology, Jagiellonian University Medical College, Faculty of MedicineDepartment of Lymphoid Malignancies, Maria Sklodowska-Curie National Research Institute of OncologyDepartment of Bone Marrow Transplantation and Oncohematology, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice BranchDepartment of Hematology and Transplantology, Medical University of Gdańsk, Faculty of Medicine and University Clinical CenterDepartament of Hematology, Cellular Therapies and Internal Medicine, Medical University, WroclawAbstract Primary pulmonary lymphoma (PPL) is a rare extranodal lymphoma, accounting for only 0.4% of all lymphomas. We conducted a retrospective analysis of 78 patients with PPL treated at 15 tertiary care hematooncology centers in Poland. The study revealed a high incidence of aggressive B-cell lymphoma (42%), although this may reflect the specificity of participating centers. A high prevalence of pleural effusion and dyspnea at the time of diagnosis was found to be associated with worse overall survival in all PPL patients. Dyspnea and bilateral lung lesions at presentation were associated with a lack of complete remission, while the presence of cough was associated with shorter time to disease progression or relapse. Although the progression-free survival did not differ significantly between patients with low- versus high-grade B-cell PPLs, those with indolent PPLs exhibited superior overall survival. To the best of our knowledge, this study is the first multicenter retrospective analysis of PPL in Central Europe involving such a large cohort of patients.https://doi.org/10.1038/s41598-025-12469-7Non-Hodgkin lymphomaPrimary pulmonary lymphomaExtranodal lymphomaAggressive B-cell lymphoma |
| spellingShingle | Agnieszka Giza Paulina Dumnicka Elżbieta Kalicińska Joanna Romejko-Jarosińska Joanna Drozd-Sokołowska Aleksander Kania Dagmara Zimowska-Curyło Wanda Knopińska-Posłuszny Grażyna Siewior Renata Guzicka-Kazimierczak Magdalena Witkowska Marta Morawska Paweł Kurczab Ewa Kalinka Marta Handzlik Dariusz Giza Ewa Paszkiewicz-Kozik Sebastian Giebel Jan Maciej Zaucha Tomasz Wróbel Retrospective analysis of primary pulmonary lymphoma cases from Polish Lymphoma Research Group centers reveals associations between initial symptoms and outcomes Scientific Reports Non-Hodgkin lymphoma Primary pulmonary lymphoma Extranodal lymphoma Aggressive B-cell lymphoma |
| title | Retrospective analysis of primary pulmonary lymphoma cases from Polish Lymphoma Research Group centers reveals associations between initial symptoms and outcomes |
| title_full | Retrospective analysis of primary pulmonary lymphoma cases from Polish Lymphoma Research Group centers reveals associations between initial symptoms and outcomes |
| title_fullStr | Retrospective analysis of primary pulmonary lymphoma cases from Polish Lymphoma Research Group centers reveals associations between initial symptoms and outcomes |
| title_full_unstemmed | Retrospective analysis of primary pulmonary lymphoma cases from Polish Lymphoma Research Group centers reveals associations between initial symptoms and outcomes |
| title_short | Retrospective analysis of primary pulmonary lymphoma cases from Polish Lymphoma Research Group centers reveals associations between initial symptoms and outcomes |
| title_sort | retrospective analysis of primary pulmonary lymphoma cases from polish lymphoma research group centers reveals associations between initial symptoms and outcomes |
| topic | Non-Hodgkin lymphoma Primary pulmonary lymphoma Extranodal lymphoma Aggressive B-cell lymphoma |
| url | https://doi.org/10.1038/s41598-025-12469-7 |
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