Exploring the influence of light conditions on the antifungal, antioxidant, and cytotoxic potential of N. persica A1387
Environmental factors significantly influence the growth, metabolism, and bioactive compound synthesis of cyanobacteria, with light playing a critical role. This study evaluated the effects of red, blue, and white light at various intensities (45, 80, 120, and 200 W) on the growth rate, biomass dry...
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Elsevier
2025-03-01
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| Series: | The Microbe |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950194625000251 |
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| author | Bahareh Nowruzi Radin Norouzi Romina Norouzi |
| author_facet | Bahareh Nowruzi Radin Norouzi Romina Norouzi |
| author_sort | Bahareh Nowruzi |
| collection | DOAJ |
| description | Environmental factors significantly influence the growth, metabolism, and bioactive compound synthesis of cyanobacteria, with light playing a critical role. This study evaluated the effects of red, blue, and white light at various intensities (45, 80, 120, and 200 W) on the growth rate, biomass dry weight, cell doubling time, antioxidant activity, antifungal activity, and cytotoxicity of Neowestiellopsis persica A1387 under two photoperiod conditions (16:8 L:D and 24:0 L:D). White light significantly enhanced the growth rate and biomass production. The biomass dry weight under white light was 1.5–1.6 times higher than red light and 2–2.2 times higher than under blue light across both photoperiod conditions. Furthermore, the average specific growth rate under white light was 1.06 times higher than under red light and 1.13 times higher than under blue light for both treatments. In contrast, blue light had the most pronounced effect on antioxidant activity, increasing it by 1.01–1.02 times compared to red light and 1.21–1.22 times compared to white light, as measured by the ABTS method. No significant differences (p > 0.05) were observed in antifungal activity against Candida albicans and Aspergillus niger or in cytotoxicity against MCF-7 cells under different light treatments. GC-MS analysis identified 3-methylbutanal and 2-methylbutanal as the most abundant volatile compounds across all treatments. In conclusion, white light is optimal for growth and biomass production, while blue light enhances antioxidant activity, demonstrating their potential for optimizing bioactive compound production. |
| format | Article |
| id | doaj-art-f82b66d8f2fd44168d0280f75a2b7e2d |
| institution | Kabale University |
| issn | 2950-1946 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
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| series | The Microbe |
| spelling | doaj-art-f82b66d8f2fd44168d0280f75a2b7e2d2025-02-11T04:35:46ZengElsevierThe Microbe2950-19462025-03-016100257Exploring the influence of light conditions on the antifungal, antioxidant, and cytotoxic potential of N. persica A1387Bahareh Nowruzi0Radin Norouzi1Romina Norouzi2Department of Biotechnology, Faculty of Converging Sciences and Technologies, Islamic Azad University Science and Research Branch, Tehran, Iran; Corresponding author.Department of Biotechnology, Faculty of Converging Sciences and Technologies, Islamic Azad University Science and Research Branch, Tehran, IranDepartment of Bioinformatics, Kish International Campus, University of Tehran, Kish, IranEnvironmental factors significantly influence the growth, metabolism, and bioactive compound synthesis of cyanobacteria, with light playing a critical role. This study evaluated the effects of red, blue, and white light at various intensities (45, 80, 120, and 200 W) on the growth rate, biomass dry weight, cell doubling time, antioxidant activity, antifungal activity, and cytotoxicity of Neowestiellopsis persica A1387 under two photoperiod conditions (16:8 L:D and 24:0 L:D). White light significantly enhanced the growth rate and biomass production. The biomass dry weight under white light was 1.5–1.6 times higher than red light and 2–2.2 times higher than under blue light across both photoperiod conditions. Furthermore, the average specific growth rate under white light was 1.06 times higher than under red light and 1.13 times higher than under blue light for both treatments. In contrast, blue light had the most pronounced effect on antioxidant activity, increasing it by 1.01–1.02 times compared to red light and 1.21–1.22 times compared to white light, as measured by the ABTS method. No significant differences (p > 0.05) were observed in antifungal activity against Candida albicans and Aspergillus niger or in cytotoxicity against MCF-7 cells under different light treatments. GC-MS analysis identified 3-methylbutanal and 2-methylbutanal as the most abundant volatile compounds across all treatments. In conclusion, white light is optimal for growth and biomass production, while blue light enhances antioxidant activity, demonstrating their potential for optimizing bioactive compound production.http://www.sciencedirect.com/science/article/pii/S2950194625000251Neowestiellopsis persica A1387LightAnti-fungal activityAntioxidant activityCytotoxicity activity |
| spellingShingle | Bahareh Nowruzi Radin Norouzi Romina Norouzi Exploring the influence of light conditions on the antifungal, antioxidant, and cytotoxic potential of N. persica A1387 The Microbe Neowestiellopsis persica A1387 Light Anti-fungal activity Antioxidant activity Cytotoxicity activity |
| title | Exploring the influence of light conditions on the antifungal, antioxidant, and cytotoxic potential of N. persica A1387 |
| title_full | Exploring the influence of light conditions on the antifungal, antioxidant, and cytotoxic potential of N. persica A1387 |
| title_fullStr | Exploring the influence of light conditions on the antifungal, antioxidant, and cytotoxic potential of N. persica A1387 |
| title_full_unstemmed | Exploring the influence of light conditions on the antifungal, antioxidant, and cytotoxic potential of N. persica A1387 |
| title_short | Exploring the influence of light conditions on the antifungal, antioxidant, and cytotoxic potential of N. persica A1387 |
| title_sort | exploring the influence of light conditions on the antifungal antioxidant and cytotoxic potential of n persica a1387 |
| topic | Neowestiellopsis persica A1387 Light Anti-fungal activity Antioxidant activity Cytotoxicity activity |
| url | http://www.sciencedirect.com/science/article/pii/S2950194625000251 |
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