Evaluation of the Effects of Different Bacteroides vulgatus Strains against DSS-Induced Colitis
Although the strain-dependent effects of Bacteroides vulgatus on alleviating intestinal inflammatory diseases have been demonstrated, the literature has rarely focused on the underlying causes of this effect. In this study, we selected four B. vulgatus strains (FTJS5K1, FTJS7K1, FSDTA11B14, and FSDL...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/9117805 |
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| author | Sijia Li Chen Wang Chengcheng Zhang Yanhong Luo Qianqian Cheng Leilei Yu Zhen Sun |
| author_facet | Sijia Li Chen Wang Chengcheng Zhang Yanhong Luo Qianqian Cheng Leilei Yu Zhen Sun |
| author_sort | Sijia Li |
| collection | DOAJ |
| description | Although the strain-dependent effects of Bacteroides vulgatus on alleviating intestinal inflammatory diseases have been demonstrated, the literature has rarely focused on the underlying causes of this effect. In this study, we selected four B. vulgatus strains (FTJS5K1, FTJS7K1, FSDTA11B14, and FSDLZ51K1) with different genomic characteristics and evaluated their protective roles against dextran sulfate sodium- (DSS-) induced colitis. Compared to the other three tested strains, B. vulgatus 7K1 more strongly ameliorated the DSS-induced weight loss, shortening of the colon length, increased disease activity index scores, colonic tissue injury, and immunomodulatory disorder. In contrast, B. vulgatus 51K1 significantly worsened the DSS-induced alterations in the tumor necrosis factor-alpha (TNF-α) concentration and colonic histopathology. A comparative genomic analysis of B. vulgatus 7K1 and 51K1 showed that the beneficial effects of B. vulgatus 7K1 may be associated with some of its specific genes involved in the production of short-chain fatty acids or capsular polysaccharides and enhancement of its survivability in the gut. In conclusion, these findings indicate that the supplementation of B. vulgatus 7K1 is a potentially efficacious intervention for alleviating colitis and provides scientific support for the screening of probiotics with anticolitis effect. |
| format | Article |
| id | doaj-art-f82352c4a6634a488889425ad109bcd4 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-f82352c4a6634a488889425ad109bcd42025-02-03T01:28:29ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/91178059117805Evaluation of the Effects of Different Bacteroides vulgatus Strains against DSS-Induced ColitisSijia Li0Chen Wang1Chengcheng Zhang2Yanhong Luo3Qianqian Cheng4Leilei Yu5Zhen Sun6School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, ChinaAlthough the strain-dependent effects of Bacteroides vulgatus on alleviating intestinal inflammatory diseases have been demonstrated, the literature has rarely focused on the underlying causes of this effect. In this study, we selected four B. vulgatus strains (FTJS5K1, FTJS7K1, FSDTA11B14, and FSDLZ51K1) with different genomic characteristics and evaluated their protective roles against dextran sulfate sodium- (DSS-) induced colitis. Compared to the other three tested strains, B. vulgatus 7K1 more strongly ameliorated the DSS-induced weight loss, shortening of the colon length, increased disease activity index scores, colonic tissue injury, and immunomodulatory disorder. In contrast, B. vulgatus 51K1 significantly worsened the DSS-induced alterations in the tumor necrosis factor-alpha (TNF-α) concentration and colonic histopathology. A comparative genomic analysis of B. vulgatus 7K1 and 51K1 showed that the beneficial effects of B. vulgatus 7K1 may be associated with some of its specific genes involved in the production of short-chain fatty acids or capsular polysaccharides and enhancement of its survivability in the gut. In conclusion, these findings indicate that the supplementation of B. vulgatus 7K1 is a potentially efficacious intervention for alleviating colitis and provides scientific support for the screening of probiotics with anticolitis effect.http://dx.doi.org/10.1155/2021/9117805 |
| spellingShingle | Sijia Li Chen Wang Chengcheng Zhang Yanhong Luo Qianqian Cheng Leilei Yu Zhen Sun Evaluation of the Effects of Different Bacteroides vulgatus Strains against DSS-Induced Colitis Journal of Immunology Research |
| title | Evaluation of the Effects of Different Bacteroides vulgatus Strains against DSS-Induced Colitis |
| title_full | Evaluation of the Effects of Different Bacteroides vulgatus Strains against DSS-Induced Colitis |
| title_fullStr | Evaluation of the Effects of Different Bacteroides vulgatus Strains against DSS-Induced Colitis |
| title_full_unstemmed | Evaluation of the Effects of Different Bacteroides vulgatus Strains against DSS-Induced Colitis |
| title_short | Evaluation of the Effects of Different Bacteroides vulgatus Strains against DSS-Induced Colitis |
| title_sort | evaluation of the effects of different bacteroides vulgatus strains against dss induced colitis |
| url | http://dx.doi.org/10.1155/2021/9117805 |
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