PD-L1+ macrophages suppress T cell-mediated anticancer immunity

PD-L1+ macrophages suppress T cell-mediated anticancer immunity

Recently, we showed that an autologous DC-based vaccine induces an increase in immunosuppressive PD-L1+ tumor-associated macrophages (TAM) both in the tumor and the tumor draining lymph nodes, thereby blunting the efficacy of therapeutic immunization. Only the combination of the DC vaccine with anti...

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Bibliographic Details
Main Authors: Peng Liu, Liwei Zhao, Guido Kroemer, Oliver Kepp
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:OncoImmunology
Subjects:
Cancer
Immunotherapy
DC vaccine
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2024.2338951
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