RS, S (+) - and R (−)-ibuprofen cocrystal polymorphs: Vibrational spectra, XRD measurement and DFT calculation studies

RS, S (+) - and R (−)-ibuprofen cocrystal polymorphs: Vibrational spectra, XRD measurement and DFT calculation studies

In this paper, cocrystal polymorphs of RS-ibuprofen (RS-IBU), S (+)-ibuprofen (S(+)-IBU), R (−)-ibuprofen (R(−)-IBU) with nicotinamide (NIC) were synthesized by different methods. RS-IBU is a chiral drug with only one chiral center in the molecule, which has two enantiomers (S (+)-IBU and R (−)-IBU)...

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Bibliographic Details
Main Authors: Yaqi Jing, Qiuhui Zhao, Jiale Zhang, Jiadan Xue, Jianjun Liu, Jianyuan Qin, Zhi Hong, Yong Du
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Heliyon
Subjects:
Chiral structure of ibuprofen
Nicotinamide
Cocrystal polymorphism
Vibrational spectra
XRD measurement
Structural optimization
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025003664
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