Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium.

Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium.

<h4>Purpose</h4>In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with...

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Main Authors: Bertrand Moal, Arthur Orieux, Thomas Ferté, Antoine Neuraz, Gabriel A Brat, Paul Avillach, Clara-Lea Bonzel, Tianxi Cai, Kelly Cho, Sébastien Cossin, Romain Griffier, David A Hanauer, Christian Haverkamp, Yuk-Lam Ho, Chuan Hong, Meghan R Hutch, Jeffrey G Klann, Trang T Le, Ne Hooi Will Loh, Yuan Luo, Adeline Makoudjou, Michele Morris, Danielle L Mowery, Karen L Olson, Lav P Patel, Malarkodi J Samayamuthu, Fernando J Sanz Vidorreta, Emily R Schriver, Petra Schubert, Guillaume Verdy, Shyam Visweswaran, Xuan Wang, Griffin M Weber, Zongqi Xia, William Yuan, Harrison G Zhang, Daniela Zöller, Isaac S Kohane, Consortium for Clinical Characterization of COVID-19 by EHR (4CE), Alexandre Boyer, Vianney Jouhet
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0266985&type=printable
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Summary:<h4>Purpose</h4>In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population.<h4>Methods</h4>A retrospective cohort study was conducted between January 1st, 2020 and February 28th, 2021 using patient-level electronic health records (EHR), across 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR (4CE). To identify the risk factors associated with ARDS, we compared young patients with and without ARDS through a federated analysis. We further compared the outcomes between young and old patients with ARDS.<h4>Results</h4>Among the 75,377 hospitalized patients with positive SARS-CoV-2 PCR, 1001 young adults presented with ARDS (7.8% of young hospitalized adults). Their mortality rate at 90 days was 16.2% and they presented with a similar complication rate for infection than older adults with ARDS. Peptic ulcer disease, paralysis, obesity, congestive heart failure, valvular disease, diabetes, chronic pulmonary disease and liver disease were associated with a higher risk of ARDS. We described a high prevalence of obesity (53%), hypertension (38%- although not significantly associated with ARDS), and diabetes (32%).<h4>Conclusion</h4>Trough an innovative method, a large international cohort study of young adults developing ARDS after SARS-CoV-2 infection has been gather. It demonstrated the poor outcomes of this population and associated risk factor.
ISSN:1932-6203

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