Fibroblasts in rheumatoid arthritis: novel roles in joint inflammation and beyond
High-throughput technologies in human and animal studies have revealed novel molecular and cellular pathways involved in tissue inflammation of rheumatoid arthritis (RA). Fibroblasts have been in the forefront of research for several decades. Subpopulations with specific phenotypic and functional pr...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1376925/full |
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| author | Elpida Neofotistou-Themeli Elpida Neofotistou-Themeli Panagiota Goutakoli Panagiota Goutakoli Theodoros Chanis Theodoros Chanis Maria Semitekolou Maria Semitekolou Eirini Sevdali Eirini Sevdali Prodromos Sidiropoulos Prodromos Sidiropoulos |
| author_facet | Elpida Neofotistou-Themeli Elpida Neofotistou-Themeli Panagiota Goutakoli Panagiota Goutakoli Theodoros Chanis Theodoros Chanis Maria Semitekolou Maria Semitekolou Eirini Sevdali Eirini Sevdali Prodromos Sidiropoulos Prodromos Sidiropoulos |
| author_sort | Elpida Neofotistou-Themeli |
| collection | DOAJ |
| description | High-throughput technologies in human and animal studies have revealed novel molecular and cellular pathways involved in tissue inflammation of rheumatoid arthritis (RA). Fibroblasts have been in the forefront of research for several decades. Subpopulations with specific phenotypic and functional properties have been characterized both in mouse models and human disease. Data supporting the active involvement of fibroblasts in immune responses and tissue remodeling processes, as well as their central role in promoting clinical relapses and contributing to treatment resistance, have clearly reshaped their role in disease evolution. The lung is an important non-synovial component of RA both from a clinical and an immunopathogenic aspect. Interstitial lung disease (ILD) is a significant contributor to disease burden affecting morbidity and mortality. Although our knowledge of ILD has progressed, significant gaps in both basic and clinical science remain, posing hurdles to efficient diagnosis, prediction of disease course and its effective treatment. The specific role and contribution of fibroblasts to this process has not been clearly defined. The focus of this review is on fibroblasts and their contribution to RA and RA-ILD, presenting data on genetics and immune responses associated with RA-ILD in humans and animal models. |
| format | Article |
| id | doaj-art-f7efd4de860b4d579268af228432bfaa |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-f7efd4de860b4d579268af228432bfaa2025-01-21T05:43:36ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.13769251376925Fibroblasts in rheumatoid arthritis: novel roles in joint inflammation and beyondElpida Neofotistou-Themeli0Elpida Neofotistou-Themeli1Panagiota Goutakoli2Panagiota Goutakoli3Theodoros Chanis4Theodoros Chanis5Maria Semitekolou6Maria Semitekolou7Eirini Sevdali8Eirini Sevdali9Prodromos Sidiropoulos10Prodromos Sidiropoulos11Laboratory of Rheumatology, Autoimmunity and Inflammation, University of Crete, Medical School, Heraklion, GreeceInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas (FORTH), Heraklion, GreeceLaboratory of Rheumatology, Autoimmunity and Inflammation, University of Crete, Medical School, Heraklion, GreeceInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas (FORTH), Heraklion, GreeceDivision of Immunology and Allergy, Department of Medicine, Karolinska Institute, Solna, SwedenCenter for Molecular Medicine, Karolinska Institute, Stockholm, SwedenDendritic Cells and Adaptive Immunity Unit, Immunology Department, Pasteur Institute, Paris, FranceDevelopmental Biology and Stem Cells, UMR3738 – National Center for Scientific Research (CNRS), Pasteur Institute, Paris, FranceLaboratory of Rheumatology, Autoimmunity and Inflammation, University of Crete, Medical School, Heraklion, GreeceInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas (FORTH), Heraklion, GreeceLaboratory of Rheumatology, Autoimmunity and Inflammation, University of Crete, Medical School, Heraklion, GreeceInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas (FORTH), Heraklion, GreeceHigh-throughput technologies in human and animal studies have revealed novel molecular and cellular pathways involved in tissue inflammation of rheumatoid arthritis (RA). Fibroblasts have been in the forefront of research for several decades. Subpopulations with specific phenotypic and functional properties have been characterized both in mouse models and human disease. Data supporting the active involvement of fibroblasts in immune responses and tissue remodeling processes, as well as their central role in promoting clinical relapses and contributing to treatment resistance, have clearly reshaped their role in disease evolution. The lung is an important non-synovial component of RA both from a clinical and an immunopathogenic aspect. Interstitial lung disease (ILD) is a significant contributor to disease burden affecting morbidity and mortality. Although our knowledge of ILD has progressed, significant gaps in both basic and clinical science remain, posing hurdles to efficient diagnosis, prediction of disease course and its effective treatment. The specific role and contribution of fibroblasts to this process has not been clearly defined. The focus of this review is on fibroblasts and their contribution to RA and RA-ILD, presenting data on genetics and immune responses associated with RA-ILD in humans and animal models.https://www.frontiersin.org/articles/10.3389/fmed.2024.1376925/fullrheumatoid arthritisfibroblastinterstitial lung disease (ILD)synoviumlungACPA |
| spellingShingle | Elpida Neofotistou-Themeli Elpida Neofotistou-Themeli Panagiota Goutakoli Panagiota Goutakoli Theodoros Chanis Theodoros Chanis Maria Semitekolou Maria Semitekolou Eirini Sevdali Eirini Sevdali Prodromos Sidiropoulos Prodromos Sidiropoulos Fibroblasts in rheumatoid arthritis: novel roles in joint inflammation and beyond Frontiers in Medicine rheumatoid arthritis fibroblast interstitial lung disease (ILD) synovium lung ACPA |
| title | Fibroblasts in rheumatoid arthritis: novel roles in joint inflammation and beyond |
| title_full | Fibroblasts in rheumatoid arthritis: novel roles in joint inflammation and beyond |
| title_fullStr | Fibroblasts in rheumatoid arthritis: novel roles in joint inflammation and beyond |
| title_full_unstemmed | Fibroblasts in rheumatoid arthritis: novel roles in joint inflammation and beyond |
| title_short | Fibroblasts in rheumatoid arthritis: novel roles in joint inflammation and beyond |
| title_sort | fibroblasts in rheumatoid arthritis novel roles in joint inflammation and beyond |
| topic | rheumatoid arthritis fibroblast interstitial lung disease (ILD) synovium lung ACPA |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1376925/full |
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