The Effect of Hybrid Blood Purification Combined with Ulinastatin for the Treatment of Severe Sepsis on APACHE II Score and Levels of miR-146a and miR-155
Kai Wang, Jihong Zhu, Weibo Gao, Wei Guo, Yang Guo Department of Emergency, Peking University People’s Hospital, Beijing, 100044, People’s Republic of ChinaCorrespondence: Yang Guo; Wei Guo, Email edguoyang@163.com; woaiguowei111@sina.comBackground: Severe sepsis is a systemic inflammatory response...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2024-12-01
|
| Series: | International Journal of General Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-effect-of-hybrid-blood-purification-combined-with-ulinastatin-for--peer-reviewed-fulltext-article-IJGM |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850169118359027712 |
|---|---|
| author | Wang K Zhu J Gao W Guo W Guo Y |
| author_facet | Wang K Zhu J Gao W Guo W Guo Y |
| author_sort | Wang K |
| collection | DOAJ |
| description | Kai Wang, Jihong Zhu, Weibo Gao, Wei Guo, Yang Guo Department of Emergency, Peking University People’s Hospital, Beijing, 100044, People’s Republic of ChinaCorrespondence: Yang Guo; Wei Guo, Email edguoyang@163.com; woaiguowei111@sina.comBackground: Severe sepsis is a systemic inflammatory response syndrome caused by infection, and the Acute Physiological Assessment and Chronic Health Evaluation II (APACHE II) scoring system is widely used to assess the severity of severe patients. Hybrid blood purification treatment (HBPT) and ulinastatin (UTI) have shown good efficacy in a variety of inflammatory diseases, and miR-146a and miR-155 were found to be closely related to inflammatory reaction. The purpose of this study was to investigate the effect of HBPT combined with UTI in the treatment of patients with severe sepsis, especially the effects on APACHE II score and miR-146a and miR-155 levels.Methods: We carried out a retrospective analysis of clinical data with severe sepsis admitted to our hospital from January 2020 to June 2022. The patients were divided into an HBPT or HBPT+UTI group according to the treatment records. The APACHE II score, miR-146a level, miR-155 level, inflammatory factors, and rehabilitation status of both groups were analyzed and compared before and after treatment.Results: A total of 150 were included in the analysis, there were 77 participants in HBPT+UTI and 73 in HBPT group. After treatment, the APACHE II score and levels of miR-146a, miR-155, and inflammatory factors were significantly lower than that before treatment. Furthermore, the HBPT+UTI group showed significantly lower values than the HBPT group (all P < 0.05). The recovery time of serum amylase, the disappearance time of abdominal pain, and the length of hospitalization in the HBPT+UTI group were significantly shorter than those in the HBPT group (all P < 0.05).Conclusion: UTI treatment combined with the administration of HBPT could improve the APACHE II score, alleviate the inflammatory reaction, and significantly improve the short-term prognosis of the patients with severe sepsis.Keywords: hybrid blood purification treatment, ulinastatin, APACHE II score, miR-146a, miR-155, severe sepsis |
| format | Article |
| id | doaj-art-f7ef8a7bcb0b4262a58a04a09bf0d985 |
| institution | OA Journals |
| issn | 1178-7074 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj-art-f7ef8a7bcb0b4262a58a04a09bf0d9852025-08-20T02:20:48ZengDove Medical PressInternational Journal of General Medicine1178-70742024-12-01Volume 175897590598125The Effect of Hybrid Blood Purification Combined with Ulinastatin for the Treatment of Severe Sepsis on APACHE II Score and Levels of miR-146a and miR-155Wang KZhu JGao WGuo WGuo YKai Wang, Jihong Zhu, Weibo Gao, Wei Guo, Yang Guo Department of Emergency, Peking University People’s Hospital, Beijing, 100044, People’s Republic of ChinaCorrespondence: Yang Guo; Wei Guo, Email edguoyang@163.com; woaiguowei111@sina.comBackground: Severe sepsis is a systemic inflammatory response syndrome caused by infection, and the Acute Physiological Assessment and Chronic Health Evaluation II (APACHE II) scoring system is widely used to assess the severity of severe patients. Hybrid blood purification treatment (HBPT) and ulinastatin (UTI) have shown good efficacy in a variety of inflammatory diseases, and miR-146a and miR-155 were found to be closely related to inflammatory reaction. The purpose of this study was to investigate the effect of HBPT combined with UTI in the treatment of patients with severe sepsis, especially the effects on APACHE II score and miR-146a and miR-155 levels.Methods: We carried out a retrospective analysis of clinical data with severe sepsis admitted to our hospital from January 2020 to June 2022. The patients were divided into an HBPT or HBPT+UTI group according to the treatment records. The APACHE II score, miR-146a level, miR-155 level, inflammatory factors, and rehabilitation status of both groups were analyzed and compared before and after treatment.Results: A total of 150 were included in the analysis, there were 77 participants in HBPT+UTI and 73 in HBPT group. After treatment, the APACHE II score and levels of miR-146a, miR-155, and inflammatory factors were significantly lower than that before treatment. Furthermore, the HBPT+UTI group showed significantly lower values than the HBPT group (all P < 0.05). The recovery time of serum amylase, the disappearance time of abdominal pain, and the length of hospitalization in the HBPT+UTI group were significantly shorter than those in the HBPT group (all P < 0.05).Conclusion: UTI treatment combined with the administration of HBPT could improve the APACHE II score, alleviate the inflammatory reaction, and significantly improve the short-term prognosis of the patients with severe sepsis.Keywords: hybrid blood purification treatment, ulinastatin, APACHE II score, miR-146a, miR-155, severe sepsishttps://www.dovepress.com/the-effect-of-hybrid-blood-purification-combined-with-ulinastatin-for--peer-reviewed-fulltext-article-IJGMhybrid blood purification treatmentulinastatinapache ii scoremir-146amir-155severe sepsis |
| spellingShingle | Wang K Zhu J Gao W Guo W Guo Y The Effect of Hybrid Blood Purification Combined with Ulinastatin for the Treatment of Severe Sepsis on APACHE II Score and Levels of miR-146a and miR-155 International Journal of General Medicine hybrid blood purification treatment ulinastatin apache ii score mir-146a mir-155 severe sepsis |
| title | The Effect of Hybrid Blood Purification Combined with Ulinastatin for the Treatment of Severe Sepsis on APACHE II Score and Levels of miR-146a and miR-155 |
| title_full | The Effect of Hybrid Blood Purification Combined with Ulinastatin for the Treatment of Severe Sepsis on APACHE II Score and Levels of miR-146a and miR-155 |
| title_fullStr | The Effect of Hybrid Blood Purification Combined with Ulinastatin for the Treatment of Severe Sepsis on APACHE II Score and Levels of miR-146a and miR-155 |
| title_full_unstemmed | The Effect of Hybrid Blood Purification Combined with Ulinastatin for the Treatment of Severe Sepsis on APACHE II Score and Levels of miR-146a and miR-155 |
| title_short | The Effect of Hybrid Blood Purification Combined with Ulinastatin for the Treatment of Severe Sepsis on APACHE II Score and Levels of miR-146a and miR-155 |
| title_sort | effect of hybrid blood purification combined with ulinastatin for the treatment of severe sepsis on apache ii score and levels of mir 146a and mir 155 |
| topic | hybrid blood purification treatment ulinastatin apache ii score mir-146a mir-155 severe sepsis |
| url | https://www.dovepress.com/the-effect-of-hybrid-blood-purification-combined-with-ulinastatin-for--peer-reviewed-fulltext-article-IJGM |
| work_keys_str_mv | AT wangk theeffectofhybridbloodpurificationcombinedwithulinastatinforthetreatmentofseveresepsisonapacheiiscoreandlevelsofmir146aandmir155 AT zhuj theeffectofhybridbloodpurificationcombinedwithulinastatinforthetreatmentofseveresepsisonapacheiiscoreandlevelsofmir146aandmir155 AT gaow theeffectofhybridbloodpurificationcombinedwithulinastatinforthetreatmentofseveresepsisonapacheiiscoreandlevelsofmir146aandmir155 AT guow theeffectofhybridbloodpurificationcombinedwithulinastatinforthetreatmentofseveresepsisonapacheiiscoreandlevelsofmir146aandmir155 AT guoy theeffectofhybridbloodpurificationcombinedwithulinastatinforthetreatmentofseveresepsisonapacheiiscoreandlevelsofmir146aandmir155 AT wangk effectofhybridbloodpurificationcombinedwithulinastatinforthetreatmentofseveresepsisonapacheiiscoreandlevelsofmir146aandmir155 AT zhuj effectofhybridbloodpurificationcombinedwithulinastatinforthetreatmentofseveresepsisonapacheiiscoreandlevelsofmir146aandmir155 AT gaow effectofhybridbloodpurificationcombinedwithulinastatinforthetreatmentofseveresepsisonapacheiiscoreandlevelsofmir146aandmir155 AT guow effectofhybridbloodpurificationcombinedwithulinastatinforthetreatmentofseveresepsisonapacheiiscoreandlevelsofmir146aandmir155 AT guoy effectofhybridbloodpurificationcombinedwithulinastatinforthetreatmentofseveresepsisonapacheiiscoreandlevelsofmir146aandmir155 |