Evidence that the periaqueductal gray matter mediates the facilitation of panic-like reactions in neonatally-isolated adult rats.

Plenty of evidence suggests that childhood separation anxiety (CSA) predisposes the subject to adult-onset panic disorder (PD). As well, panic is frequently comorbid with both anxiety and depression. The brain mechanisms whereby CSA predisposes to PD are but completely unknown in spite of the increa...

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Bibliographic Details
Main Authors: Jeyce Willig Quintino-dos-Santos, Cláudia Janaína Torres Müller, Cristie Setúbal Bernabé, Caroline Azevedo Rosa, Sérgio Tufik, Luiz Carlos Schenberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090726&type=printable
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