Lipid metabolism-associated metabolites on cardiovascular diseases: a two-sample Mendelian randomized study
BackgroundThere is a growing body of evidence indicating that metabolites are associated with an increased risk of cardiovascular diseases (CVDs), the underlying causality of these associations remains largely unchallenged. Given the inherent difficulty in establishing causality using epidemiologica...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1445732/full |
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| author | Jia-Le Chen Jia-Le Chen Xin-Yi Lu Xin-Yi Lu Dao-Zhen Chen Dao-Zhen Chen Yu Chen |
| author_facet | Jia-Le Chen Jia-Le Chen Xin-Yi Lu Xin-Yi Lu Dao-Zhen Chen Dao-Zhen Chen Yu Chen |
| author_sort | Jia-Le Chen |
| collection | DOAJ |
| description | BackgroundThere is a growing body of evidence indicating that metabolites are associated with an increased risk of cardiovascular diseases (CVDs), the underlying causality of these associations remains largely unchallenged. Given the inherent difficulty in establishing causality using epidemiological data, we employed the technique of Mendelian randomization to investigate the potential role of plasma metabolite factors in influencing the risk of CVDs.MethodsThe exposure was based on 1,400 plasma metabolites, and outcomes involved four CVD datasets from public databases. Initial causality was assessed by inverse variance weighting (IVW), followed by sensitivity analyses using MR-Egger regression, weighted median, and Multiple Effectiveness Residual Sums and Outliers (MR-PRESSO) method. Potential heterogeneity and multivalence were assessed using the MR-Egger intercept and Cochran's Q statistic. After Bonferroni correction, causal associations were found to be significant with p-values less than 0.05. All statistical analyses were rigorously executed in R software.ResultsOur findings identified causal relationships between 15 metabolites and cardiovascular disease. Of these, 4 were associated with AA (aortic aneurysm), 7 with atrial fibrillation and flutter, 2 with HF (heart failure), and 3 with stroke.ConclusionThis is the first systematic mendelian randomization analysis using genome-wide data to assess the causal relationship between serum metabolites and different cardiovascular diseases, providing preliminary evidence for the impact of lipid metabolism disorders on cardiovascular disease risk. |
| format | Article |
| id | doaj-art-f7e207c8e2464dcab55c8a8761c38c9d |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-f7e207c8e2464dcab55c8a8761c38c9d2025-08-20T03:44:28ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-03-011210.3389/fcvm.2025.14457321445732Lipid metabolism-associated metabolites on cardiovascular diseases: a two-sample Mendelian randomized studyJia-Le Chen0Jia-Le Chen1Xin-Yi Lu2Xin-Yi Lu3Dao-Zhen Chen4Dao-Zhen Chen5Yu Chen6Hospital Infection Management Section, Wujin Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Changzhou, Jiangsu, ChinaWuxi Maternal and Child Health Hospital, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, ChinaWuxi Maternal and Child Health Hospital, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, ChinaWuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu, ChinaWuxi Maternal and Child Health Hospital, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, ChinaWuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu, ChinaWuxi Maternal and Child Health Hospital, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, ChinaBackgroundThere is a growing body of evidence indicating that metabolites are associated with an increased risk of cardiovascular diseases (CVDs), the underlying causality of these associations remains largely unchallenged. Given the inherent difficulty in establishing causality using epidemiological data, we employed the technique of Mendelian randomization to investigate the potential role of plasma metabolite factors in influencing the risk of CVDs.MethodsThe exposure was based on 1,400 plasma metabolites, and outcomes involved four CVD datasets from public databases. Initial causality was assessed by inverse variance weighting (IVW), followed by sensitivity analyses using MR-Egger regression, weighted median, and Multiple Effectiveness Residual Sums and Outliers (MR-PRESSO) method. Potential heterogeneity and multivalence were assessed using the MR-Egger intercept and Cochran's Q statistic. After Bonferroni correction, causal associations were found to be significant with p-values less than 0.05. All statistical analyses were rigorously executed in R software.ResultsOur findings identified causal relationships between 15 metabolites and cardiovascular disease. Of these, 4 were associated with AA (aortic aneurysm), 7 with atrial fibrillation and flutter, 2 with HF (heart failure), and 3 with stroke.ConclusionThis is the first systematic mendelian randomization analysis using genome-wide data to assess the causal relationship between serum metabolites and different cardiovascular diseases, providing preliminary evidence for the impact of lipid metabolism disorders on cardiovascular disease risk.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1445732/fullplasma metabolitescardiovascular diseaseglycolipid metabolic disordersMendelian randomizationsingle-nucleotide polymorphismsrisk factors |
| spellingShingle | Jia-Le Chen Jia-Le Chen Xin-Yi Lu Xin-Yi Lu Dao-Zhen Chen Dao-Zhen Chen Yu Chen Lipid metabolism-associated metabolites on cardiovascular diseases: a two-sample Mendelian randomized study Frontiers in Cardiovascular Medicine plasma metabolites cardiovascular disease glycolipid metabolic disorders Mendelian randomization single-nucleotide polymorphisms risk factors |
| title | Lipid metabolism-associated metabolites on cardiovascular diseases: a two-sample Mendelian randomized study |
| title_full | Lipid metabolism-associated metabolites on cardiovascular diseases: a two-sample Mendelian randomized study |
| title_fullStr | Lipid metabolism-associated metabolites on cardiovascular diseases: a two-sample Mendelian randomized study |
| title_full_unstemmed | Lipid metabolism-associated metabolites on cardiovascular diseases: a two-sample Mendelian randomized study |
| title_short | Lipid metabolism-associated metabolites on cardiovascular diseases: a two-sample Mendelian randomized study |
| title_sort | lipid metabolism associated metabolites on cardiovascular diseases a two sample mendelian randomized study |
| topic | plasma metabolites cardiovascular disease glycolipid metabolic disorders Mendelian randomization single-nucleotide polymorphisms risk factors |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1445732/full |
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