Single-chain recombinant clotting factor VIII (lonoctocog alfa): clinical experience in Russia
Despite significant progress in haemophilia treatment, achieved in Russia recently, number of unmet medical needs still exist in routine clinical practice. Particularly, the annual bleeding rates are still high, leading to frequent development of synovitis and haemophilic arthropathy, resulting in c...
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| Language: | Russian |
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Open Systems Publication
2022-02-01
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| Series: | Лечащий Врач |
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| Online Access: | https://journal.lvrach.ru/jour/article/view/886 |
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| author | M. V. Kosinova |
| author_facet | M. V. Kosinova |
| author_sort | M. V. Kosinova |
| collection | DOAJ |
| description | Despite significant progress in haemophilia treatment, achieved in Russia recently, number of unmet medical needs still exist in routine clinical practice. Particularly, the annual bleeding rates are still high, leading to frequent development of synovitis and haemophilic arthropathy, resulting in chronic pain and impaired joint motility. Thus, the quality of life of patients with haemophilia is not optimal. One of potential approaches to improve the situation could be more wide use in routine clinical practice recombinant clotting factors with extended half-life. According to modern clinical guidelines on haemophilia treatment, such products could potentially significantly decrease number of infusions for prophylactic therapy without decrease in efficacy of haemostasis control or keeping the same infusion frequency could increase the clotting factors activity, improving the patient’s protection from bleeds. Thus, use of recombinant clotting factors with extended half-life can increase the patient’s compliance to treatment and the results of therapy. One of such molecules is single-chain recombinant clotting factor VIII (lonoctocog alfa). The modification of this molecule leads to improvement of its stability and affinity to von Willebrand factor, allowing to increase the intervals between infusion up to 2-3 times per week for all age groups. This article describes the clinical trial program of lonoctocog alfa and summarize the results of its use among haemophilia patients in Russia. Large international clinical program AFFINITY has demonstrated high efficacy and favorable safety profile of lonoctocog alfa and the analysis of Russian patient’s treatment results demonstrated, that they are in line with such results worldwide. |
| format | Article |
| id | doaj-art-f7de7eb16e614b4e9ae7e315ee2a5315 |
| institution | DOAJ |
| issn | 1560-5175 2687-1181 |
| language | Russian |
| publishDate | 2022-02-01 |
| publisher | Open Systems Publication |
| record_format | Article |
| series | Лечащий Врач |
| spelling | doaj-art-f7de7eb16e614b4e9ae7e315ee2a53152025-08-20T03:20:16ZrusOpen Systems PublicationЛечащий Врач1560-51752687-11812022-02-0102495310.51793/OS.2022.25.2.008881Single-chain recombinant clotting factor VIII (lonoctocog alfa): clinical experience in RussiaM. V. Kosinova0State Autonomous Healthcare Institution Kuzbass clinical hospital named by S. V. BelyaevDespite significant progress in haemophilia treatment, achieved in Russia recently, number of unmet medical needs still exist in routine clinical practice. Particularly, the annual bleeding rates are still high, leading to frequent development of synovitis and haemophilic arthropathy, resulting in chronic pain and impaired joint motility. Thus, the quality of life of patients with haemophilia is not optimal. One of potential approaches to improve the situation could be more wide use in routine clinical practice recombinant clotting factors with extended half-life. According to modern clinical guidelines on haemophilia treatment, such products could potentially significantly decrease number of infusions for prophylactic therapy without decrease in efficacy of haemostasis control or keeping the same infusion frequency could increase the clotting factors activity, improving the patient’s protection from bleeds. Thus, use of recombinant clotting factors with extended half-life can increase the patient’s compliance to treatment and the results of therapy. One of such molecules is single-chain recombinant clotting factor VIII (lonoctocog alfa). The modification of this molecule leads to improvement of its stability and affinity to von Willebrand factor, allowing to increase the intervals between infusion up to 2-3 times per week for all age groups. This article describes the clinical trial program of lonoctocog alfa and summarize the results of its use among haemophilia patients in Russia. Large international clinical program AFFINITY has demonstrated high efficacy and favorable safety profile of lonoctocog alfa and the analysis of Russian patient’s treatment results demonstrated, that they are in line with such results worldwide.https://journal.lvrach.ru/jour/article/view/886haemophiliableedingarthropathyquality of lifeclotting factor viiilonoctocog alfa |
| spellingShingle | M. V. Kosinova Single-chain recombinant clotting factor VIII (lonoctocog alfa): clinical experience in Russia Лечащий Врач haemophilia bleeding arthropathy quality of life clotting factor viii lonoctocog alfa |
| title | Single-chain recombinant clotting factor VIII (lonoctocog alfa): clinical experience in Russia |
| title_full | Single-chain recombinant clotting factor VIII (lonoctocog alfa): clinical experience in Russia |
| title_fullStr | Single-chain recombinant clotting factor VIII (lonoctocog alfa): clinical experience in Russia |
| title_full_unstemmed | Single-chain recombinant clotting factor VIII (lonoctocog alfa): clinical experience in Russia |
| title_short | Single-chain recombinant clotting factor VIII (lonoctocog alfa): clinical experience in Russia |
| title_sort | single chain recombinant clotting factor viii lonoctocog alfa clinical experience in russia |
| topic | haemophilia bleeding arthropathy quality of life clotting factor viii lonoctocog alfa |
| url | https://journal.lvrach.ru/jour/article/view/886 |
| work_keys_str_mv | AT mvkosinova singlechainrecombinantclottingfactorviiilonoctocogalfaclinicalexperienceinrussia |