BAAV mediated GJB2 gene transfer restores gap junction coupling in cochlear organotypic cultures from deaf Cx26Sox10Cre mice.

BAAV mediated GJB2 gene transfer restores gap junction coupling in cochlear organotypic cultures from deaf Cx26Sox10Cre mice.

The deafness locus DFNB1 contains GJB2, the gene encoding connexin26 and GJB6, encoding connexin30, which appear to be coordinately regulated in the inner ear. In this work, we investigated the expression and function of connexin26 and connexin30 from postnatal day 5 to adult age in double transgeni...

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Main Authors: Giulia Crispino, Giovanni Di Pasquale, Pietro Scimemi, Laura Rodriguez, Fabian Galindo Ramirez, Romolo Daniele De Siati, Rosa Maria Santarelli, Edoardo Arslan, Mario Bortolozzi, John A Chiorini, Fabio Mammano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0023279&type=printable
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