GC-MS analysis, antimicrobial and antiulcer evaluations of ginger-infused virgin coconut oil
Medicinal herb-infused oil is utilized in folkloric medicine due to its efficacy in ameliorating various diseases of humans; even with this evidence, most herbs are still underutilized and poorly investigated. This prompted the investigation of ginger-infused virgin coconut oil's chemical comp...
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German Journal of Pharmaceuticals and Biomaterials
2025-01-01
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| Series: | German Journal of Pharmaceuticals and Biomaterials |
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| Online Access: | https://www.gjpb.de/index.php/gjpb/article/view/130 |
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| author | Ibeabuchi Jude Ali Okorie Ndidiamaka H Adonu Cyril C Omeh Romanus C Obidiegwu Onyeka C Okonkwo Raymond M Okafor Judith O Okoye Festus BC |
| author_facet | Ibeabuchi Jude Ali Okorie Ndidiamaka H Adonu Cyril C Omeh Romanus C Obidiegwu Onyeka C Okonkwo Raymond M Okafor Judith O Okoye Festus BC |
| author_sort | Ibeabuchi Jude Ali |
| collection | DOAJ |
| description |
Medicinal herb-infused oil is utilized in folkloric medicine due to its efficacy in ameliorating various diseases of humans; even with this evidence, most herbs are still underutilized and poorly investigated. This prompted the investigation of ginger-infused virgin coconut oil's chemical composition and antimicrobial and antiulcer activities (GIVCO). The virgin coconut oil was produced using the natural fermentation method. Dried ginger and VCO (1:10) were infused for three days and then filtered to obtain ginger-infused virgin coconut oil. GC-MS was used to detect GIVCO chemical constituents. The agar well diffusion method was used for antimicrobial evaluation test organisms. The ethanol and indomethacin-induced ulcer models were used for antiulcer evaluation. The GC-MS
analysis identified the presence of lauric acid methyl ester, Myristic acid, Palmitic Acid, Oleic acid, Capric acid, Stearic acid, Caryophyllene, Docosahexaenoic Acid methyl ester. At 100 mg/ml, inhibition zone diameter (IZD) ranged from 10-16 mm for various strains of bacteria and 10-21 mm for various strains of fungi. The effect of GIVCO on tested organisms compared favorably to that of standard drugs. The acute toxicity study of GIVCO is atoxic. The antiulcer activity demonstrated a dose-dependent effect; at 100 mg/ml, the GIVCO protected the intestine with a %UI of 80 and 63 for ethanol and indomethacin model against the standard omeprazole with 50% UI. The study demonstrated the potential of GIVCO as an alternative medicine against antimicrobial infections and the prevention of stomach ulcers.
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| format | Article |
| id | doaj-art-f7c6469a4a794b0c98675efd6dbc6982 |
| institution | Kabale University |
| issn | 2750-624X 2750-6258 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | German Journal of Pharmaceuticals and Biomaterials |
| record_format | Article |
| series | German Journal of Pharmaceuticals and Biomaterials |
| spelling | doaj-art-f7c6469a4a794b0c98675efd6dbc69822025-02-11T06:26:20ZengGerman Journal of Pharmaceuticals and BiomaterialsGerman Journal of Pharmaceuticals and Biomaterials2750-624X2750-62582025-01-013410.5530/gjpb.2024.4.14GC-MS analysis, antimicrobial and antiulcer evaluations of ginger-infused virgin coconut oilIbeabuchi Jude Ali0Okorie Ndidiamaka H1Adonu Cyril C2Omeh Romanus C3Obidiegwu Onyeka C4Okonkwo Raymond M5Okafor Judith O6Okoye Festus BC7Department of Pharmaceutical Chemistry Enugu State University of Science and Technology Agbani, Enugu State.Department of Pharmaceutical Chemistry Enugu State University of Science and Technology Agbani, Enugu State.Department of Pharmaceutical Microbiology and Biotechnology, Enugu State University of Science and Technology Agbani, Enugu State.Department of Pharmaceutics and Pharmaceutical Technology Enugu State University of Science and Technology Agbani, Enugu State.Department of Pharmaceutical and Medicinal Chemistry, Nnamdi Azikiwe University Awka, Anambra State.Department of Pharmacology Enugu State University of Science and Technology Agbani, Enugu State.Department of Pharmaceutical Chemistry Enugu State University of Science and Technology Agbani, Enugu State.Department of Pharmaceutical and Medicinal Chemistry, Nnamdi Azikiwe University Awka, Anambra State. Medicinal herb-infused oil is utilized in folkloric medicine due to its efficacy in ameliorating various diseases of humans; even with this evidence, most herbs are still underutilized and poorly investigated. This prompted the investigation of ginger-infused virgin coconut oil's chemical composition and antimicrobial and antiulcer activities (GIVCO). The virgin coconut oil was produced using the natural fermentation method. Dried ginger and VCO (1:10) were infused for three days and then filtered to obtain ginger-infused virgin coconut oil. GC-MS was used to detect GIVCO chemical constituents. The agar well diffusion method was used for antimicrobial evaluation test organisms. The ethanol and indomethacin-induced ulcer models were used for antiulcer evaluation. The GC-MS analysis identified the presence of lauric acid methyl ester, Myristic acid, Palmitic Acid, Oleic acid, Capric acid, Stearic acid, Caryophyllene, Docosahexaenoic Acid methyl ester. At 100 mg/ml, inhibition zone diameter (IZD) ranged from 10-16 mm for various strains of bacteria and 10-21 mm for various strains of fungi. The effect of GIVCO on tested organisms compared favorably to that of standard drugs. The acute toxicity study of GIVCO is atoxic. The antiulcer activity demonstrated a dose-dependent effect; at 100 mg/ml, the GIVCO protected the intestine with a %UI of 80 and 63 for ethanol and indomethacin model against the standard omeprazole with 50% UI. The study demonstrated the potential of GIVCO as an alternative medicine against antimicrobial infections and the prevention of stomach ulcers. https://www.gjpb.de/index.php/gjpb/article/view/130infused oilgingerphytochemicalsulcermicroorganismsvirgin coconut oil |
| spellingShingle | Ibeabuchi Jude Ali Okorie Ndidiamaka H Adonu Cyril C Omeh Romanus C Obidiegwu Onyeka C Okonkwo Raymond M Okafor Judith O Okoye Festus BC GC-MS analysis, antimicrobial and antiulcer evaluations of ginger-infused virgin coconut oil German Journal of Pharmaceuticals and Biomaterials infused oil ginger phytochemicals ulcer microorganisms virgin coconut oil |
| title | GC-MS analysis, antimicrobial and antiulcer evaluations of ginger-infused virgin coconut oil |
| title_full | GC-MS analysis, antimicrobial and antiulcer evaluations of ginger-infused virgin coconut oil |
| title_fullStr | GC-MS analysis, antimicrobial and antiulcer evaluations of ginger-infused virgin coconut oil |
| title_full_unstemmed | GC-MS analysis, antimicrobial and antiulcer evaluations of ginger-infused virgin coconut oil |
| title_short | GC-MS analysis, antimicrobial and antiulcer evaluations of ginger-infused virgin coconut oil |
| title_sort | gc ms analysis antimicrobial and antiulcer evaluations of ginger infused virgin coconut oil |
| topic | infused oil ginger phytochemicals ulcer microorganisms virgin coconut oil |
| url | https://www.gjpb.de/index.php/gjpb/article/view/130 |
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