Enhanced Antitumor Activity with Combining Effect of mTOR Inhibition and Microtubule Stabilization in Hepatocellular Carcinoma

Enhanced Antitumor Activity with Combining Effect of mTOR Inhibition and Microtubule Stabilization in Hepatocellular Carcinoma

Mammalian target of rapamycin (mTOR) and the microtubules are shown to be potential targets for treating hepatocellular carcinoma (HCC). PI3K/Akt/mTOR activation is associated with resistance to microtubule inhibitors. Here, we evaluated the antitumor activity by cotargeting of the mTOR (using allos...

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Bibliographic Details
Main Authors: Qian Zhou, Chi Hang Wong, Cecilia Pik Yuk Lau, Connie Wun Chun Hui, Vivian Wai Yan Lui, Stephen Lam Chan, Winnie Yeo
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:International Journal of Hepatology
Online Access:http://dx.doi.org/10.1155/2013/103830
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