Leveraging pleiotropic clustering to address high proportion correlated horizontal pleiotropy in Mendelian randomization studies

Leveraging pleiotropic clustering to address high proportion correlated horizontal pleiotropy in Mendelian randomization studies

Abstract Mendelian randomization harnesses genetic variants as instrumental variables to infer causal relationships between exposures and outcomes. However, certain genetic variants can affect both the exposure and the outcome through a shared factor. This phenomenon, called correlated horizontal pl...

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Bibliographic Details
Main Authors: Bin Tang, Nan Lin, Junhao Liang, Guorong Yi, Liubin Zhang, Wenjie Peng, Chao Xue, Hui Jiang, Miaoxin Li
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57912-5
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