Muscle-homing peptides modified biomimetic curcumin nanoparticles ameliorate skeletal muscle dysfunction in aging mice
With increasing age, skeletal muscle gradually loses mass and strength, and the risk of falls and fractures escalates among elderly individuals. Inflammation is closely related to age-related muscle atrophy and is the potential target for treating muscular atrophy. Here, biomimetic curcumin nanopart...
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| Language: | English |
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Elsevier
2025-07-01
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| Series: | Redox Biology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231725001922 |
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| author | Jianjie Xie Zongyu Huang Nana Gao Huicong Feng Biaobiao Wang Shuang Gao He Tian Chao Wu Chang Liu |
| author_facet | Jianjie Xie Zongyu Huang Nana Gao Huicong Feng Biaobiao Wang Shuang Gao He Tian Chao Wu Chang Liu |
| author_sort | Jianjie Xie |
| collection | DOAJ |
| description | With increasing age, skeletal muscle gradually loses mass and strength, and the risk of falls and fractures escalates among elderly individuals. Inflammation is closely related to age-related muscle atrophy and is the potential target for treating muscular atrophy. Here, biomimetic curcumin nanoparticles (M12MNCs) are prepared via encapsulating curcumin in the skeletal muscle cell membranes modified via muscle-homing peptides (M12) for the treatment of aging related skeletal muscle atrophy. The M12MNCs have good biocompatibility and can be enriched in aging skeletal muscle. After treatment with the M12MNCs, aging mice present enhanced motor ability and improved skeletal muscle metabolism. The results of in vivo and in vitro experiments confirm that M12MNCs reduce inflammation and decrease the expression of α-synuclein (α-syn). In addition, M12MNCs ameliorate skeletal muscle dysfunction in aging mice via regulating the SphK1/Spns2/S1PR2 axis. This study provides a therapeutic target of inflammatory and myogenic factors to improve the function of aging skeletal muscle, which provides valuable insights for the subsequent treatment of aging-related skeletal muscle function. These findings suggest that M12MNCs can improve age-related skeletal muscle dysfunction by modulating inflammation and cell proliferation, and can be used as a novel drug delivery system for clinical therapeutic regimens for muscle atrophy. |
| format | Article |
| id | doaj-art-f7b8e4edb29641fdb3635313488bdcaa |
| institution | Kabale University |
| issn | 2213-2317 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj-art-f7b8e4edb29641fdb3635313488bdcaa2025-08-20T03:53:52ZengElsevierRedox Biology2213-23172025-07-018410367910.1016/j.redox.2025.103679Muscle-homing peptides modified biomimetic curcumin nanoparticles ameliorate skeletal muscle dysfunction in aging miceJianjie Xie0Zongyu Huang1Nana Gao2Huicong Feng3Biaobiao Wang4Shuang Gao5He Tian6Chao Wu7Chang Liu8Department of Endocrinology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, 121001, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, 121001, ChinaSchool of Basic Medicine, Jinzhou Medical University, Jinzhou, Liaoning, 121001, ChinaSchool of Basic Medicine, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China; Liaoning Provincial Collaborative Innovation Center of Medical Testing and Drug Development, Jinzhou, Liaoning, 121001, ChinaSchool of Pharmacy, Jinzhou Medical University, Jinzhou, Liaoning, 121001, ChinaSchool of Basic Medicine, Jinzhou Medical University, Jinzhou, Liaoning, 121001, ChinaSchool of Basic Medicine, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China; Liaoning Provincial Collaborative Innovation Center of Medical Testing and Drug Development, Jinzhou, Liaoning, 121001, China; Corresponding author. School of Basic Medicine, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.Liaoning Provincial Collaborative Innovation Center of Medical Testing and Drug Development, Jinzhou, Liaoning, 121001, China; School of Pharmacy, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China; Corresponding author. School of Pharmacy, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.Department of Endocrinology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, 121001, China; Liaoning Provincial Key Laboratory of Medical Tissue Engineering, Jinzhou, Liaoning, 121001, China; Corresponding author. Department of Endocrinology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.With increasing age, skeletal muscle gradually loses mass and strength, and the risk of falls and fractures escalates among elderly individuals. Inflammation is closely related to age-related muscle atrophy and is the potential target for treating muscular atrophy. Here, biomimetic curcumin nanoparticles (M12MNCs) are prepared via encapsulating curcumin in the skeletal muscle cell membranes modified via muscle-homing peptides (M12) for the treatment of aging related skeletal muscle atrophy. The M12MNCs have good biocompatibility and can be enriched in aging skeletal muscle. After treatment with the M12MNCs, aging mice present enhanced motor ability and improved skeletal muscle metabolism. The results of in vivo and in vitro experiments confirm that M12MNCs reduce inflammation and decrease the expression of α-synuclein (α-syn). In addition, M12MNCs ameliorate skeletal muscle dysfunction in aging mice via regulating the SphK1/Spns2/S1PR2 axis. This study provides a therapeutic target of inflammatory and myogenic factors to improve the function of aging skeletal muscle, which provides valuable insights for the subsequent treatment of aging-related skeletal muscle function. These findings suggest that M12MNCs can improve age-related skeletal muscle dysfunction by modulating inflammation and cell proliferation, and can be used as a novel drug delivery system for clinical therapeutic regimens for muscle atrophy.http://www.sciencedirect.com/science/article/pii/S2213231725001922AgingSkeletal muscleCurcuminInflammationNanocrystalMuscle-homing peptide |
| spellingShingle | Jianjie Xie Zongyu Huang Nana Gao Huicong Feng Biaobiao Wang Shuang Gao He Tian Chao Wu Chang Liu Muscle-homing peptides modified biomimetic curcumin nanoparticles ameliorate skeletal muscle dysfunction in aging mice Redox Biology Aging Skeletal muscle Curcumin Inflammation Nanocrystal Muscle-homing peptide |
| title | Muscle-homing peptides modified biomimetic curcumin nanoparticles ameliorate skeletal muscle dysfunction in aging mice |
| title_full | Muscle-homing peptides modified biomimetic curcumin nanoparticles ameliorate skeletal muscle dysfunction in aging mice |
| title_fullStr | Muscle-homing peptides modified biomimetic curcumin nanoparticles ameliorate skeletal muscle dysfunction in aging mice |
| title_full_unstemmed | Muscle-homing peptides modified biomimetic curcumin nanoparticles ameliorate skeletal muscle dysfunction in aging mice |
| title_short | Muscle-homing peptides modified biomimetic curcumin nanoparticles ameliorate skeletal muscle dysfunction in aging mice |
| title_sort | muscle homing peptides modified biomimetic curcumin nanoparticles ameliorate skeletal muscle dysfunction in aging mice |
| topic | Aging Skeletal muscle Curcumin Inflammation Nanocrystal Muscle-homing peptide |
| url | http://www.sciencedirect.com/science/article/pii/S2213231725001922 |
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