Plasma α-Glutathione S-Transferase Evaluation in Patients with Acute and Chronic Liver Injury
High concentration of alpha-glutathione S-transferase (α-GST) in the liver and its short half-life make this enzyme clinically useful in assessing hepatocellular damage. We aimed to investigate the significance of α-GST evaluation in monitoring of liver injury in acute and chronic liver diseases. 20...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2019/5850787 |
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| author | Jolanta Czuczejko Celestyna Mila-Kierzenkowska Karolina Szewczyk-Golec |
| author_facet | Jolanta Czuczejko Celestyna Mila-Kierzenkowska Karolina Szewczyk-Golec |
| author_sort | Jolanta Czuczejko |
| collection | DOAJ |
| description | High concentration of alpha-glutathione S-transferase (α-GST) in the liver and its short half-life make this enzyme clinically useful in assessing hepatocellular damage. We aimed to investigate the significance of α-GST evaluation in monitoring of liver injury in acute and chronic liver diseases. 20 healthy volunteers and 52 patients were included in the study. The patients were divided into three groups: group I (acute viral hepatitis B or C), group II (chronic hepatitis B or C), and group III (chronic liver disease or cirrhosis with different etiologies). The concentration of α-GST and the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured in all examined groups. α-GST, ALT, and AST were statistically higher in all patient groups than in the control group. Statistically higher values of all assessed parameters were observed in group I compared with remaining patients. Statistically higher activities of ALT and AST are observed in group III compared with group II. Significant positive correlations were noted between α-GST and ALT/AST in groups I and III. The results indicate that the assay of α-GST in combination with the other conventional markers may be found as a confirmatory test for hepatocellular damage. |
| format | Article |
| id | doaj-art-f7b84844952f467b8d9af6fa2f61040d |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-f7b84844952f467b8d9af6fa2f61040d2025-02-03T00:59:15ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972019-01-01201910.1155/2019/58507875850787Plasma α-Glutathione S-Transferase Evaluation in Patients with Acute and Chronic Liver InjuryJolanta Czuczejko0Celestyna Mila-Kierzenkowska1Karolina Szewczyk-Golec2Department of Psychiatry, Ludwik Rydygier Collegium Medicum of Nicolaus Copernicus University, 9 M. Curie Skłodowskiej St, 85-094 Bydgoszcz, PolandDepartment of Medical Biology and Biochemistry, Ludwik Rydygier Collegium Medicum of Nicolaus Copernicus University, 24 Karłowicza St, 85-092 Bydgoszcz, PolandDepartment of Medical Biology and Biochemistry, Ludwik Rydygier Collegium Medicum of Nicolaus Copernicus University, 24 Karłowicza St, 85-092 Bydgoszcz, PolandHigh concentration of alpha-glutathione S-transferase (α-GST) in the liver and its short half-life make this enzyme clinically useful in assessing hepatocellular damage. We aimed to investigate the significance of α-GST evaluation in monitoring of liver injury in acute and chronic liver diseases. 20 healthy volunteers and 52 patients were included in the study. The patients were divided into three groups: group I (acute viral hepatitis B or C), group II (chronic hepatitis B or C), and group III (chronic liver disease or cirrhosis with different etiologies). The concentration of α-GST and the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured in all examined groups. α-GST, ALT, and AST were statistically higher in all patient groups than in the control group. Statistically higher values of all assessed parameters were observed in group I compared with remaining patients. Statistically higher activities of ALT and AST are observed in group III compared with group II. Significant positive correlations were noted between α-GST and ALT/AST in groups I and III. The results indicate that the assay of α-GST in combination with the other conventional markers may be found as a confirmatory test for hepatocellular damage.http://dx.doi.org/10.1155/2019/5850787 |
| spellingShingle | Jolanta Czuczejko Celestyna Mila-Kierzenkowska Karolina Szewczyk-Golec Plasma α-Glutathione S-Transferase Evaluation in Patients with Acute and Chronic Liver Injury Canadian Journal of Gastroenterology and Hepatology |
| title | Plasma α-Glutathione S-Transferase Evaluation in Patients with Acute and Chronic Liver Injury |
| title_full | Plasma α-Glutathione S-Transferase Evaluation in Patients with Acute and Chronic Liver Injury |
| title_fullStr | Plasma α-Glutathione S-Transferase Evaluation in Patients with Acute and Chronic Liver Injury |
| title_full_unstemmed | Plasma α-Glutathione S-Transferase Evaluation in Patients with Acute and Chronic Liver Injury |
| title_short | Plasma α-Glutathione S-Transferase Evaluation in Patients with Acute and Chronic Liver Injury |
| title_sort | plasma α glutathione s transferase evaluation in patients with acute and chronic liver injury |
| url | http://dx.doi.org/10.1155/2019/5850787 |
| work_keys_str_mv | AT jolantaczuczejko plasmaaglutathionestransferaseevaluationinpatientswithacuteandchronicliverinjury AT celestynamilakierzenkowska plasmaaglutathionestransferaseevaluationinpatientswithacuteandchronicliverinjury AT karolinaszewczykgolec plasmaaglutathionestransferaseevaluationinpatientswithacuteandchronicliverinjury |