Three-dimensional histological imaging of primate brain and correlation with in vivo medical device images

The 3D reconstruction of series of histological slices is an imaging technique that appeared about 25 years ago but that is only starting now to become recognized as an imaging modality per se. Thanks to this technique, it becomes possible to restore the spatial consistency of the brain and to match...

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Main Author: Julien Dauguet
Format: Article
Language:English
Published: Société Francophone de Primatologie 2011-02-01
Series:Revue de Primatologie
Subjects:
Online Access:https://journals.openedition.org/primatologie/546
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author Julien Dauguet
author_facet Julien Dauguet
author_sort Julien Dauguet
collection DOAJ
description The 3D reconstruction of series of histological slices is an imaging technique that appeared about 25 years ago but that is only starting now to become recognized as an imaging modality per se. Thanks to this technique, it becomes possible to restore the spatial consistency of the brain and to match accurately histological slices with an in vivo medical device image such as an MRI or a PET scan. This is of high interest since it allows direct comparison between the histology, often considered as the gold standard in terms of information, and the same medical devices used in clinical routine to image human patients. Thanks to the similarity of their brain with humans and the disease models widely developed for them, non-human primates are privileged species to benefit from this possibility of 3D analysis and in vivo - post mortem correlation. We present in this article a state of the art review of the main techniques proposed to achieve this original imaging technique, followed by a set of some particularly promising neuroimaging applications.
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spelling doaj-art-f7ab3207fc2942f993678e72326c24d62025-01-30T10:01:43ZengSociété Francophone de PrimatologieRevue de Primatologie2077-37572011-02-01210.4000/primatologie.546Three-dimensional histological imaging of primate brain and correlation with in vivo medical device imagesJulien DauguetThe 3D reconstruction of series of histological slices is an imaging technique that appeared about 25 years ago but that is only starting now to become recognized as an imaging modality per se. Thanks to this technique, it becomes possible to restore the spatial consistency of the brain and to match accurately histological slices with an in vivo medical device image such as an MRI or a PET scan. This is of high interest since it allows direct comparison between the histology, often considered as the gold standard in terms of information, and the same medical devices used in clinical routine to image human patients. Thanks to the similarity of their brain with humans and the disease models widely developed for them, non-human primates are privileged species to benefit from this possibility of 3D analysis and in vivo - post mortem correlation. We present in this article a state of the art review of the main techniques proposed to achieve this original imaging technique, followed by a set of some particularly promising neuroimaging applications.https://journals.openedition.org/primatologie/5463D histological imagingin vivo-post mortem correlationmedical imaging
spellingShingle Julien Dauguet
Three-dimensional histological imaging of primate brain and correlation with in vivo medical device images
Revue de Primatologie
3D histological imaging
in vivo-post mortem correlation
medical imaging
title Three-dimensional histological imaging of primate brain and correlation with in vivo medical device images
title_full Three-dimensional histological imaging of primate brain and correlation with in vivo medical device images
title_fullStr Three-dimensional histological imaging of primate brain and correlation with in vivo medical device images
title_full_unstemmed Three-dimensional histological imaging of primate brain and correlation with in vivo medical device images
title_short Three-dimensional histological imaging of primate brain and correlation with in vivo medical device images
title_sort three dimensional histological imaging of primate brain and correlation with in vivo medical device images
topic 3D histological imaging
in vivo-post mortem correlation
medical imaging
url https://journals.openedition.org/primatologie/546
work_keys_str_mv AT juliendauguet threedimensionalhistologicalimagingofprimatebrainandcorrelationwithinvivomedicaldeviceimages