ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells

ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells

Homeobox genes play an important role in health and disease including oncogenesis. The present investigation aimed to study ERN1-dependent hypoxic regulation of the expression of genes encoding homeobox proteins MEIS (zinc finger E-box binding homeobox 2) and LIM homeobox 1 family, SPAG4 (sperm asso...

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Main Authors: Krasnytska Daria A., Khita Olena O., Viletska Yuliia M., Minchenko Dmytro O., Halkin Oleh V., Rudnytska Olha V., Hoian Sofiia L., Minchenko Oleksandr H.
Format: Article
Language:English
Published: Sciendo 2024-01-01
Series:Endocrine Regulations
Subjects:
u87mg glioblastoma cells
ern1 knockdown
hypoxia
homeobox genes
mrna expression
Online Access:https://doi.org/10.2478/enr-2024-0006
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Summary:Homeobox genes play an important role in health and disease including oncogenesis. The present investigation aimed to study ERN1-dependent hypoxic regulation of the expression of genes encoding homeobox proteins MEIS (zinc finger E-box binding homeobox 2) and LIM homeobox 1 family, SPAG4 (sperm associated antigen 4) and NKX3-1 (NK3 homeobox 1) in U87MG glioblastoma cells in response to inhibition of ERN1 (endoplasmic reticulum to nucleus signaling 1) for evaluation of their possible significance in the control of glioblastoma growth.
ISSN:1336-0329

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