The Relationship between Cadherin Polymorphisms and the Risk of Delayed Encephalopathy after Acute Carbon Monoxide Poisoning in the Chinese Han Population
Objective. The purpose of this study was to analyze the relationship between cadherin gene single-nucleotide polymorphisms (SNPs) and the risk of delayed encephalopathy after acute carbon monoxide poisoning (DEACMP). Materials and Methods. A total of 416 patients with DEACMP and 754 patients with ac...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2022/3155703 |
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| _version_ | 1832563607073718272 |
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| author | Xuejiao Liu Jiao Zeng Xiaoli Zhang Jiapeng Gu Fan Zhang Yongkai Han Ping Zhang Wenqiang Li Renjun Gu |
| author_facet | Xuejiao Liu Jiao Zeng Xiaoli Zhang Jiapeng Gu Fan Zhang Yongkai Han Ping Zhang Wenqiang Li Renjun Gu |
| author_sort | Xuejiao Liu |
| collection | DOAJ |
| description | Objective. The purpose of this study was to analyze the relationship between cadherin gene single-nucleotide polymorphisms (SNPs) and the risk of delayed encephalopathy after acute carbon monoxide poisoning (DEACMP). Materials and Methods. A total of 416 patients with DEACMP and 754 patients with acute carbon monoxide poisoning (ACMP) were recruited. We used the Sequenom MassARRAY® system to detect cadherin gene SNPs related to DEACMP. Using different genetic analysis models, we evaluated the relationship between the cadherin gene polymorphisms and risk of DEACMP. Results. We found that rs1944294 in the N-cadherin (CDH2) gene showed significant differences in genotype frequencies between the two groups under codominant and dominant inheritance models. Similarly, rs2513796 in the cadherin-17 (CDH17) gene showed significant differences under the codominant, dominant, and overdominant genetic models. And the T allele frequency of rs1944294 in the DEACMP group was significantly higher than that in the ACMP group (P=0.023). Conclusions. Cadherin gene SNPs (rs1944294, rs2513796) are associated with an increased risk of DEACMP in the Chinese population. |
| format | Article |
| id | doaj-art-f7a1f7b56a694501a2e4c3d324ac93b1 |
| institution | Kabale University |
| issn | 1875-8584 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-f7a1f7b56a694501a2e4c3d324ac93b12025-02-03T01:13:05ZengWileyBehavioural Neurology1875-85842022-01-01202210.1155/2022/3155703The Relationship between Cadherin Polymorphisms and the Risk of Delayed Encephalopathy after Acute Carbon Monoxide Poisoning in the Chinese Han PopulationXuejiao Liu0Jiao Zeng1Xiaoli Zhang2Jiapeng Gu3Fan Zhang4Yongkai Han5Ping Zhang6Wenqiang Li7Renjun Gu8The Second Affiliated Hospital of Xinxiang Medical UniversityThe Second Affiliated Hospital of Xinxiang Medical UniversityThe Second Affiliated Hospital of Xinxiang Medical UniversityThe Second Affiliated Hospital of Xinxiang Medical UniversityThe Second Affiliated Hospital of Xinxiang Medical UniversityThe Second Affiliated Hospital of Xinxiang Medical UniversityThe Second Affiliated Hospital of Xinxiang Medical UniversityThe Second Affiliated Hospital of Xinxiang Medical UniversityThe Second Affiliated Hospital of Xinxiang Medical UniversityObjective. The purpose of this study was to analyze the relationship between cadherin gene single-nucleotide polymorphisms (SNPs) and the risk of delayed encephalopathy after acute carbon monoxide poisoning (DEACMP). Materials and Methods. A total of 416 patients with DEACMP and 754 patients with acute carbon monoxide poisoning (ACMP) were recruited. We used the Sequenom MassARRAY® system to detect cadherin gene SNPs related to DEACMP. Using different genetic analysis models, we evaluated the relationship between the cadherin gene polymorphisms and risk of DEACMP. Results. We found that rs1944294 in the N-cadherin (CDH2) gene showed significant differences in genotype frequencies between the two groups under codominant and dominant inheritance models. Similarly, rs2513796 in the cadherin-17 (CDH17) gene showed significant differences under the codominant, dominant, and overdominant genetic models. And the T allele frequency of rs1944294 in the DEACMP group was significantly higher than that in the ACMP group (P=0.023). Conclusions. Cadherin gene SNPs (rs1944294, rs2513796) are associated with an increased risk of DEACMP in the Chinese population.http://dx.doi.org/10.1155/2022/3155703 |
| spellingShingle | Xuejiao Liu Jiao Zeng Xiaoli Zhang Jiapeng Gu Fan Zhang Yongkai Han Ping Zhang Wenqiang Li Renjun Gu The Relationship between Cadherin Polymorphisms and the Risk of Delayed Encephalopathy after Acute Carbon Monoxide Poisoning in the Chinese Han Population Behavioural Neurology |
| title | The Relationship between Cadherin Polymorphisms and the Risk of Delayed Encephalopathy after Acute Carbon Monoxide Poisoning in the Chinese Han Population |
| title_full | The Relationship between Cadherin Polymorphisms and the Risk of Delayed Encephalopathy after Acute Carbon Monoxide Poisoning in the Chinese Han Population |
| title_fullStr | The Relationship between Cadherin Polymorphisms and the Risk of Delayed Encephalopathy after Acute Carbon Monoxide Poisoning in the Chinese Han Population |
| title_full_unstemmed | The Relationship between Cadherin Polymorphisms and the Risk of Delayed Encephalopathy after Acute Carbon Monoxide Poisoning in the Chinese Han Population |
| title_short | The Relationship between Cadherin Polymorphisms and the Risk of Delayed Encephalopathy after Acute Carbon Monoxide Poisoning in the Chinese Han Population |
| title_sort | relationship between cadherin polymorphisms and the risk of delayed encephalopathy after acute carbon monoxide poisoning in the chinese han population |
| url | http://dx.doi.org/10.1155/2022/3155703 |
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