Evaluation of the relationship between cardiac calcification and cardiovascular disease using the echocardiographic calcium score in patients undergoing peritoneal dialysis: a cross-sectional study
Introduction: An echocardiographic calcium score (ECS) predicts cardiovascular disease (CVD) in the general population. Its utility in peritoneal dialysis (PD) patients is unknown. Methods: This cross-sectional study assessed 125 patients on PD. The ECS (range 0–8) was compared between subjects with...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer – Medknow Publications
2023-06-01
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| Series: | Singapore Medical Journal |
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| Online Access: | https://journals.lww.com/10.11622/smedj.2022052 |
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| author | Ho-Kwan Sin Ping-Nam Wong Kin-Yee Lo Man-Wai Lo Shuk-Fan Chan Kwok-Chi Lo Yuk-Yi Wong Lo-Yi Ho Wing-Tung Kwok Kai-Chun Chan Andrew Kui-Man Wong Siu-Ka Mak |
| author_facet | Ho-Kwan Sin Ping-Nam Wong Kin-Yee Lo Man-Wai Lo Shuk-Fan Chan Kwok-Chi Lo Yuk-Yi Wong Lo-Yi Ho Wing-Tung Kwok Kai-Chun Chan Andrew Kui-Man Wong Siu-Ka Mak |
| author_sort | Ho-Kwan Sin |
| collection | DOAJ |
| description | Introduction:
An echocardiographic calcium score (ECS) predicts cardiovascular disease (CVD) in the general population. Its utility in peritoneal dialysis (PD) patients is unknown.
Methods:
This cross-sectional study assessed 125 patients on PD. The ECS (range 0–8) was compared between subjects with CVD and those without.
Results:
Among the subjects, 54 had CVD and 71 did not. Subjects with CVD were older (69 years vs. 56 years, P < 0.001) and had a higher prevalence of diabetes mellitus (DM) (81.5% vs. 45.1%, P < 0.001). They had lower diastolic blood pressure (72 mmHg vs. 81 mmHg, P < 0.001), lower phosphate (1.6 mmol/L vs. 1.9 mmol/L, P = 0.002), albumin (30 g/L vs. 32 g/L, P = 0.001), parathyroid hormone (34.4 pmol/L vs. 55.8 pmol/L, P = 0.002), total cholesterol (4.5 vs. 4.9, P = 0.047), LDL cholesterol (2.4 mmol/L vs. 2.8 mmol/L, P = 0.019) and HDL cholesterol (0.8 mmol/L vs. 1.1 mmol/L, P = 0.002). The ECS was found to be higher in subjects with CVD than in those without (2 vs. 1, P = 0.001). On multivariate analysis, only DM and age were independently associated with CVD.
Conclusion:
The ECS was significantly higher in PD patients with CVD than in those without, reflecting a higher vascular calcification burden in the former. It is a potentially useful tool to quantify vascular calcification in PD patients. |
| format | Article |
| id | doaj-art-f797c41187f349509040a7ad4987d066 |
| institution | Kabale University |
| issn | 0037-5675 2737-5935 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Wolters Kluwer – Medknow Publications |
| record_format | Article |
| series | Singapore Medical Journal |
| spelling | doaj-art-f797c41187f349509040a7ad4987d0662025-02-09T13:50:01ZengWolters Kluwer – Medknow PublicationsSingapore Medical Journal0037-56752737-59352023-06-0164637938410.11622/smedj.2022052Evaluation of the relationship between cardiac calcification and cardiovascular disease using the echocardiographic calcium score in patients undergoing peritoneal dialysis: a cross-sectional studyHo-Kwan SinPing-Nam WongKin-Yee LoMan-Wai LoShuk-Fan ChanKwok-Chi LoYuk-Yi WongLo-Yi HoWing-Tung KwokKai-Chun ChanAndrew Kui-Man WongSiu-Ka MakIntroduction: An echocardiographic calcium score (ECS) predicts cardiovascular disease (CVD) in the general population. Its utility in peritoneal dialysis (PD) patients is unknown. Methods: This cross-sectional study assessed 125 patients on PD. The ECS (range 0–8) was compared between subjects with CVD and those without. Results: Among the subjects, 54 had CVD and 71 did not. Subjects with CVD were older (69 years vs. 56 years, P < 0.001) and had a higher prevalence of diabetes mellitus (DM) (81.5% vs. 45.1%, P < 0.001). They had lower diastolic blood pressure (72 mmHg vs. 81 mmHg, P < 0.001), lower phosphate (1.6 mmol/L vs. 1.9 mmol/L, P = 0.002), albumin (30 g/L vs. 32 g/L, P = 0.001), parathyroid hormone (34.4 pmol/L vs. 55.8 pmol/L, P = 0.002), total cholesterol (4.5 vs. 4.9, P = 0.047), LDL cholesterol (2.4 mmol/L vs. 2.8 mmol/L, P = 0.019) and HDL cholesterol (0.8 mmol/L vs. 1.1 mmol/L, P = 0.002). The ECS was found to be higher in subjects with CVD than in those without (2 vs. 1, P = 0.001). On multivariate analysis, only DM and age were independently associated with CVD. Conclusion: The ECS was significantly higher in PD patients with CVD than in those without, reflecting a higher vascular calcification burden in the former. It is a potentially useful tool to quantify vascular calcification in PD patients.https://journals.lww.com/10.11622/smedj.2022052calcificationcardiovascular diseaseechocardiographyend-stage renal diseaseperitoneal dialysis |
| spellingShingle | Ho-Kwan Sin Ping-Nam Wong Kin-Yee Lo Man-Wai Lo Shuk-Fan Chan Kwok-Chi Lo Yuk-Yi Wong Lo-Yi Ho Wing-Tung Kwok Kai-Chun Chan Andrew Kui-Man Wong Siu-Ka Mak Evaluation of the relationship between cardiac calcification and cardiovascular disease using the echocardiographic calcium score in patients undergoing peritoneal dialysis: a cross-sectional study Singapore Medical Journal calcification cardiovascular disease echocardiography end-stage renal disease peritoneal dialysis |
| title | Evaluation of the relationship between cardiac calcification and cardiovascular disease using the echocardiographic calcium score in patients undergoing peritoneal dialysis: a cross-sectional study |
| title_full | Evaluation of the relationship between cardiac calcification and cardiovascular disease using the echocardiographic calcium score in patients undergoing peritoneal dialysis: a cross-sectional study |
| title_fullStr | Evaluation of the relationship between cardiac calcification and cardiovascular disease using the echocardiographic calcium score in patients undergoing peritoneal dialysis: a cross-sectional study |
| title_full_unstemmed | Evaluation of the relationship between cardiac calcification and cardiovascular disease using the echocardiographic calcium score in patients undergoing peritoneal dialysis: a cross-sectional study |
| title_short | Evaluation of the relationship between cardiac calcification and cardiovascular disease using the echocardiographic calcium score in patients undergoing peritoneal dialysis: a cross-sectional study |
| title_sort | evaluation of the relationship between cardiac calcification and cardiovascular disease using the echocardiographic calcium score in patients undergoing peritoneal dialysis a cross sectional study |
| topic | calcification cardiovascular disease echocardiography end-stage renal disease peritoneal dialysis |
| url | https://journals.lww.com/10.11622/smedj.2022052 |
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