Impact of nutrition risk index, prognostic nutritional index and skeletal muscle index on early myelosuppression of first-line chemotherapy in stage IV gastric cancer patients
Abstract Background In gastric cancer (GC) patients, malnutrition is common and has a negative impact on treatment tolerance, survival, and prognosis. The purpose of this study was to explore the relationship between prechemotherapy nutritional state and early myelosuppression in stage IV GC patient...
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BMC
2024-12-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-024-03548-6 |
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| author | Juan Wei WeiFeng Xiang HangPing Wei XiaoYan Hu YiFang Lu XiaoFang Dong |
| author_facet | Juan Wei WeiFeng Xiang HangPing Wei XiaoYan Hu YiFang Lu XiaoFang Dong |
| author_sort | Juan Wei |
| collection | DOAJ |
| description | Abstract Background In gastric cancer (GC) patients, malnutrition is common and has a negative impact on treatment tolerance, survival, and prognosis. The purpose of this study was to explore the relationship between prechemotherapy nutritional state and early myelosuppression in stage IV GC patients treated with first-line chemotherapy. Methods This retrospective study included patients with stage IV GC who received first-line chemotherapy between July 2012 and December 2021. Clinical and laboratory data were collected within 1 week before chemotherapy to calculate nutrition risk index, prognostic nutritional index. Pretreatment abdominal computed tomography scans were used to quantify skeletal muscle index (SMI). The main measurable outcome was the incidence of grade ≥ 2 early myelosuppression after chemotherapy. Results Among 102 patients eligible for analysis, 50% were malnourished, 50% were poor prognoses and 49% were sarcopenic at baseline.The side effects were generally well managed, with a 26.5% occurrence of grade 3/4 side effects. Pre-chemotherapy patients with low Nutrition Risk Index (NRI) (p = 0.002), low prognostic nutritional index (PNI) (p = 0.001), and low SMI (p = 0.001) had significantly higher incidences of grade ≥ 2 myelosuppression occurred after the first cycle of chemotherapy. Moreover, the high level of PNI was associated with higher completion rate of chemotherapy (p = 0.01). Multivariate logistic regression analysis revealed that SMI at baseline (p = 0.006) and hemoglobin level (p = < 0.001) were prognostic factors for grade ≥ 2 early myelosuppression. Conclusion Stage IV GC patients with low NRI, low PNI and low SMI experienced significantly more grade ≥ 2 early myelosuppression during the first line of chemotherapy. |
| format | Article |
| id | doaj-art-f783ff7936d74d04ad67724c3b2ee840 |
| institution | Kabale University |
| issn | 1471-230X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj-art-f783ff7936d74d04ad67724c3b2ee8402024-12-22T12:29:08ZengBMCBMC Gastroenterology1471-230X2024-12-012411810.1186/s12876-024-03548-6Impact of nutrition risk index, prognostic nutritional index and skeletal muscle index on early myelosuppression of first-line chemotherapy in stage IV gastric cancer patientsJuan Wei0WeiFeng Xiang1HangPing Wei2XiaoYan Hu3YiFang Lu4XiaoFang Dong5Department of Medical Oncology, Affiliated Dongyang Hospital of Wenzhou Medical UniversityDepartment of Medical Oncology, Affiliated Dongyang Hospital of Wenzhou Medical UniversityDepartment of Medical Oncology, Affiliated Dongyang Hospital of Wenzhou Medical UniversityDepartment of Medical Oncology, Affiliated Dongyang Hospital of Wenzhou Medical UniversityDepartment of Medical Oncology, Affiliated Dongyang Hospital of Wenzhou Medical UniversityDepartment of Medical Oncology, Affiliated Dongyang Hospital of Wenzhou Medical UniversityAbstract Background In gastric cancer (GC) patients, malnutrition is common and has a negative impact on treatment tolerance, survival, and prognosis. The purpose of this study was to explore the relationship between prechemotherapy nutritional state and early myelosuppression in stage IV GC patients treated with first-line chemotherapy. Methods This retrospective study included patients with stage IV GC who received first-line chemotherapy between July 2012 and December 2021. Clinical and laboratory data were collected within 1 week before chemotherapy to calculate nutrition risk index, prognostic nutritional index. Pretreatment abdominal computed tomography scans were used to quantify skeletal muscle index (SMI). The main measurable outcome was the incidence of grade ≥ 2 early myelosuppression after chemotherapy. Results Among 102 patients eligible for analysis, 50% were malnourished, 50% were poor prognoses and 49% were sarcopenic at baseline.The side effects were generally well managed, with a 26.5% occurrence of grade 3/4 side effects. Pre-chemotherapy patients with low Nutrition Risk Index (NRI) (p = 0.002), low prognostic nutritional index (PNI) (p = 0.001), and low SMI (p = 0.001) had significantly higher incidences of grade ≥ 2 myelosuppression occurred after the first cycle of chemotherapy. Moreover, the high level of PNI was associated with higher completion rate of chemotherapy (p = 0.01). Multivariate logistic regression analysis revealed that SMI at baseline (p = 0.006) and hemoglobin level (p = < 0.001) were prognostic factors for grade ≥ 2 early myelosuppression. Conclusion Stage IV GC patients with low NRI, low PNI and low SMI experienced significantly more grade ≥ 2 early myelosuppression during the first line of chemotherapy.https://doi.org/10.1186/s12876-024-03548-6Nutrition risk indexPrognostic nutritional indexSkeletal muscle indexEarly myelosuppressionFirst-line chemotherapyStage IV gastric cancer |
| spellingShingle | Juan Wei WeiFeng Xiang HangPing Wei XiaoYan Hu YiFang Lu XiaoFang Dong Impact of nutrition risk index, prognostic nutritional index and skeletal muscle index on early myelosuppression of first-line chemotherapy in stage IV gastric cancer patients BMC Gastroenterology Nutrition risk index Prognostic nutritional index Skeletal muscle index Early myelosuppression First-line chemotherapy Stage IV gastric cancer |
| title | Impact of nutrition risk index, prognostic nutritional index and skeletal muscle index on early myelosuppression of first-line chemotherapy in stage IV gastric cancer patients |
| title_full | Impact of nutrition risk index, prognostic nutritional index and skeletal muscle index on early myelosuppression of first-line chemotherapy in stage IV gastric cancer patients |
| title_fullStr | Impact of nutrition risk index, prognostic nutritional index and skeletal muscle index on early myelosuppression of first-line chemotherapy in stage IV gastric cancer patients |
| title_full_unstemmed | Impact of nutrition risk index, prognostic nutritional index and skeletal muscle index on early myelosuppression of first-line chemotherapy in stage IV gastric cancer patients |
| title_short | Impact of nutrition risk index, prognostic nutritional index and skeletal muscle index on early myelosuppression of first-line chemotherapy in stage IV gastric cancer patients |
| title_sort | impact of nutrition risk index prognostic nutritional index and skeletal muscle index on early myelosuppression of first line chemotherapy in stage iv gastric cancer patients |
| topic | Nutrition risk index Prognostic nutritional index Skeletal muscle index Early myelosuppression First-line chemotherapy Stage IV gastric cancer |
| url | https://doi.org/10.1186/s12876-024-03548-6 |
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