Hypoglycemic polysaccharides from Auricularia auricula and Auricularia polytricha inhibit oxidative stress, NF-κB signaling and proinflammatory cytokine production in streptozotocin-induced diabetic mice
Auricularia auricula (AA) and Auricularia polytricha (AP) are popular edible fungi. This study successfully produced hypoglycemic polysaccharides from un-smashed or smashing and sieving (through a 10-mesh sieve) AA and AP (termed as AAP/AAP-10 and APP/APP-10) via scalable processes (water extraction...
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Tsinghua University Press
2021-01-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221345302030166X |
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| author | Huan Xiang Dongxiao Sun-Waterhouse Chun Cui |
| author_facet | Huan Xiang Dongxiao Sun-Waterhouse Chun Cui |
| author_sort | Huan Xiang |
| collection | DOAJ |
| description | Auricularia auricula (AA) and Auricularia polytricha (AP) are popular edible fungi. This study successfully produced hypoglycemic polysaccharides from un-smashed or smashing and sieving (through a 10-mesh sieve) AA and AP (termed as AAP/AAP-10 and APP/APP-10) via scalable processes (water extraction, ethanolic precipitation and deproteinization). This is the first report to compare the effectiveness of AAP and APP in combating streptozotocin-induced oxidative stress and diabetes-related changes in mice (body weight, fasting blood glucose, serum insulin, proinflammatory mediator and cytokines, oxidative stress-related products, antioxidant enzymes). APP and AAP with different molecular weights and monosaccharide molar ratios could be therapeutic options for diabetes with a low dose (100 mg/kg/day) likely working better. At the same dose, APP generally performed more effective than AAP, and AAP-10/APP-10 seemed slightly more beneficial than AAP/APP. One mechanism underlying these antidiabetic functions might involve the NF-κB and associated signalling pathways. AP is cheaper than AA, thereby representing a favorable source of functional polysaccharides. |
| format | Article |
| id | doaj-art-f7812568ffe84765aa5a7978a6255100 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Tsinghua University Press |
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| series | Food Science and Human Wellness |
| spelling | doaj-art-f7812568ffe84765aa5a7978a62551002025-02-03T06:51:18ZengTsinghua University PressFood Science and Human Wellness2213-45302021-01-011018793Hypoglycemic polysaccharides from Auricularia auricula and Auricularia polytricha inhibit oxidative stress, NF-κB signaling and proinflammatory cytokine production in streptozotocin-induced diabetic miceHuan Xiang0Dongxiao Sun-Waterhouse1Chun Cui2School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, Guangdong, ChinaSchool of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, Guangdong, China; School of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand; Corresponding author at: School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, Guangdong, China.School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, Guangdong, China; Guangdong Weiwei Biotechnology Co., LTD, Guangzhou, 510640, Guangdong, China; Corresponding author at: School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, Guangdong, China.Auricularia auricula (AA) and Auricularia polytricha (AP) are popular edible fungi. This study successfully produced hypoglycemic polysaccharides from un-smashed or smashing and sieving (through a 10-mesh sieve) AA and AP (termed as AAP/AAP-10 and APP/APP-10) via scalable processes (water extraction, ethanolic precipitation and deproteinization). This is the first report to compare the effectiveness of AAP and APP in combating streptozotocin-induced oxidative stress and diabetes-related changes in mice (body weight, fasting blood glucose, serum insulin, proinflammatory mediator and cytokines, oxidative stress-related products, antioxidant enzymes). APP and AAP with different molecular weights and monosaccharide molar ratios could be therapeutic options for diabetes with a low dose (100 mg/kg/day) likely working better. At the same dose, APP generally performed more effective than AAP, and AAP-10/APP-10 seemed slightly more beneficial than AAP/APP. One mechanism underlying these antidiabetic functions might involve the NF-κB and associated signalling pathways. AP is cheaper than AA, thereby representing a favorable source of functional polysaccharides.http://www.sciencedirect.com/science/article/pii/S221345302030166XPolysaccharidesAuricularia auriculaAuricularia polytrichaHypoglycemic effectOxidative stress |
| spellingShingle | Huan Xiang Dongxiao Sun-Waterhouse Chun Cui Hypoglycemic polysaccharides from Auricularia auricula and Auricularia polytricha inhibit oxidative stress, NF-κB signaling and proinflammatory cytokine production in streptozotocin-induced diabetic mice Food Science and Human Wellness Polysaccharides Auricularia auricula Auricularia polytricha Hypoglycemic effect Oxidative stress |
| title | Hypoglycemic polysaccharides from Auricularia auricula and Auricularia polytricha inhibit oxidative stress, NF-κB signaling and proinflammatory cytokine production in streptozotocin-induced diabetic mice |
| title_full | Hypoglycemic polysaccharides from Auricularia auricula and Auricularia polytricha inhibit oxidative stress, NF-κB signaling and proinflammatory cytokine production in streptozotocin-induced diabetic mice |
| title_fullStr | Hypoglycemic polysaccharides from Auricularia auricula and Auricularia polytricha inhibit oxidative stress, NF-κB signaling and proinflammatory cytokine production in streptozotocin-induced diabetic mice |
| title_full_unstemmed | Hypoglycemic polysaccharides from Auricularia auricula and Auricularia polytricha inhibit oxidative stress, NF-κB signaling and proinflammatory cytokine production in streptozotocin-induced diabetic mice |
| title_short | Hypoglycemic polysaccharides from Auricularia auricula and Auricularia polytricha inhibit oxidative stress, NF-κB signaling and proinflammatory cytokine production in streptozotocin-induced diabetic mice |
| title_sort | hypoglycemic polysaccharides from auricularia auricula and auricularia polytricha inhibit oxidative stress nf κb signaling and proinflammatory cytokine production in streptozotocin induced diabetic mice |
| topic | Polysaccharides Auricularia auricula Auricularia polytricha Hypoglycemic effect Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S221345302030166X |
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