Articulatory Changes in Vowel Production following STN DBS and Levodopa Intake in Parkinson’s Disease
Purpose. To investigate the impact of deep brain stimulation of the subthalamic nucleus (STN DBS) and levodopa intake on vowel articulation in dysarthric speakers with Parkinson’s disease (PD). Methods. Vowel articulation was assessed in seven Quebec French speakers diagnosed with idiopathic PD who...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2015/382320 |
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| author | Vincent Martel Sauvageau Johanna-Pascale Roy Léo Cantin Michel Prud’Homme Mélanie Langlois Joël Macoir |
| author_facet | Vincent Martel Sauvageau Johanna-Pascale Roy Léo Cantin Michel Prud’Homme Mélanie Langlois Joël Macoir |
| author_sort | Vincent Martel Sauvageau |
| collection | DOAJ |
| description | Purpose. To investigate the impact of deep brain stimulation of the subthalamic nucleus (STN DBS) and levodopa intake on vowel articulation in dysarthric speakers with Parkinson’s disease (PD). Methods. Vowel articulation was assessed in seven Quebec French speakers diagnosed with idiopathic PD who underwent STN DBS. Assessments were conducted on- and off-medication, first prior to surgery and then 1 year later. All recordings were made on-stimulation. Vowel articulation was measured using acoustic vowel space and formant centralization ratio. Results. Compared to the period before surgery, vowel articulation was reduced after surgery when patients were off-medication, while it was better on-medication. The impact of levodopa intake on vowel articulation changed with STN DBS: before surgery, levodopa impaired articulation, while it no longer had a negative effect after surgery. Conclusions. These results indicate that while STN DBS could lead to a direct deterioration in articulation, it may indirectly improve it by reducing the levodopa dose required to manage motor symptoms. These findings suggest that, with respect to speech production, STN DBS and levodopa intake cannot be investigated separately because the two are intrinsically linked. Along with motor symptoms, speech production should be considered when optimizing therapeutic management of patients with PD. |
| format | Article |
| id | doaj-art-f77febc2b79b41d89b2452d10b46e0d1 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-f77febc2b79b41d89b2452d10b46e0d12025-08-20T03:25:38ZengWileyParkinson's Disease2090-80832042-00802015-01-01201510.1155/2015/382320382320Articulatory Changes in Vowel Production following STN DBS and Levodopa Intake in Parkinson’s DiseaseVincent Martel Sauvageau0Johanna-Pascale Roy1Léo Cantin2Michel Prud’Homme3Mélanie Langlois4Joël Macoir5Centre Interdisciplinaire de Recherche en Réadaptation et en Intégration Sociale, Québec, QC, G1M 2S8, CanadaCentre Interdisciplinaire de Recherche sur les Activités Langagières, Université Laval, Québec, QC, G1V 0A6, CanadaDépartement des Sciences Neurologiques, CHU de Québec (Hôpital de l’Enfant-Jésus), Québec, QC, G1J 1Z4, CanadaDépartement des Sciences Neurologiques, CHU de Québec (Hôpital de l’Enfant-Jésus), Québec, QC, G1J 1Z4, CanadaDépartement des Sciences Neurologiques, CHU de Québec (Hôpital de l’Enfant-Jésus), Québec, QC, G1J 1Z4, CanadaCentre de Recherche, Institut Universitaire en Santé Mentale de Québec, Laboratoire Langage et Cognition, Québec, QC, G1J 2G3, CanadaPurpose. To investigate the impact of deep brain stimulation of the subthalamic nucleus (STN DBS) and levodopa intake on vowel articulation in dysarthric speakers with Parkinson’s disease (PD). Methods. Vowel articulation was assessed in seven Quebec French speakers diagnosed with idiopathic PD who underwent STN DBS. Assessments were conducted on- and off-medication, first prior to surgery and then 1 year later. All recordings were made on-stimulation. Vowel articulation was measured using acoustic vowel space and formant centralization ratio. Results. Compared to the period before surgery, vowel articulation was reduced after surgery when patients were off-medication, while it was better on-medication. The impact of levodopa intake on vowel articulation changed with STN DBS: before surgery, levodopa impaired articulation, while it no longer had a negative effect after surgery. Conclusions. These results indicate that while STN DBS could lead to a direct deterioration in articulation, it may indirectly improve it by reducing the levodopa dose required to manage motor symptoms. These findings suggest that, with respect to speech production, STN DBS and levodopa intake cannot be investigated separately because the two are intrinsically linked. Along with motor symptoms, speech production should be considered when optimizing therapeutic management of patients with PD.http://dx.doi.org/10.1155/2015/382320 |
| spellingShingle | Vincent Martel Sauvageau Johanna-Pascale Roy Léo Cantin Michel Prud’Homme Mélanie Langlois Joël Macoir Articulatory Changes in Vowel Production following STN DBS and Levodopa Intake in Parkinson’s Disease Parkinson's Disease |
| title | Articulatory Changes in Vowel Production following STN DBS and Levodopa Intake in Parkinson’s Disease |
| title_full | Articulatory Changes in Vowel Production following STN DBS and Levodopa Intake in Parkinson’s Disease |
| title_fullStr | Articulatory Changes in Vowel Production following STN DBS and Levodopa Intake in Parkinson’s Disease |
| title_full_unstemmed | Articulatory Changes in Vowel Production following STN DBS and Levodopa Intake in Parkinson’s Disease |
| title_short | Articulatory Changes in Vowel Production following STN DBS and Levodopa Intake in Parkinson’s Disease |
| title_sort | articulatory changes in vowel production following stn dbs and levodopa intake in parkinson s disease |
| url | http://dx.doi.org/10.1155/2015/382320 |
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