Clinical & Labor Clinical & Laboratory markers as pr ers as predictors for se ors for severity and erity and mortality in COVID-19
Backgrounds: COVID-19, a new health challenge, can be diagnosed by many laboratory biomarkers. Biomarkers became valuable for prognosis; identifying the severity and mortality of the disease in COVID-19 patients. This study aims to determine the association of clinical, demographics, and laboratory...
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Erbil Polytechnic University
2023-09-01
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| Series: | Polytechnic Journal |
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| Online Access: | https://polytechnic-journal.epu.edu.iq/home/vol13/iss1/20 |
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| author | Asma Ameen Ghareeb Sazan Moffaq Abdulaziz |
| author_facet | Asma Ameen Ghareeb Sazan Moffaq Abdulaziz |
| author_sort | Asma Ameen Ghareeb |
| collection | DOAJ |
| description | Backgrounds: COVID-19, a new health challenge, can be diagnosed by many laboratory biomarkers.
Biomarkers became valuable for prognosis; identifying the severity and mortality of the disease in
COVID-19 patients. This study aims to determine the association of clinical, demographics, and laboratory
biomarkers (CRP, D-dimer, lymphocyte, and platelet) with the severity and mortality of COVID-19. Methods:
Between June 1st and November 1st, 2020, 34 healthy controls and 104 COVID-19 cases were enrolled in
this study. SARS-CoV-2 infection was confirmed using the real-time RT-PCR technique. All cases were
analyzed for clinical, epidemiological, and laboratory biomarkers. COVID-19 cases were regrouped into
mild (n=40), moderate (n=32), and severe (n=32) groups depending on the severity of the disease; it was
also re-categorized into survivor (n=85) and non-survivor (n=19) groups depending on mortality. After
collecting blood from participants, hematological parameters (lymphocyte and platelet) and other
biomarkers (CRP and D-dimer) were measured by colter and Cobas c111, respectively. Results: For age
categories and comorbidities, Statistical significance was found among COVID-19 groups. Regarding
ABO, Rh, and gender, a non-significant difference was found among groups of COVID-19 patients. Cough
and headache i the most common symptom in our population. SpO2 depressed more significantly in
severe and moderate groups than in mild groups. Severe and moderate groups exhibit higher CRP, Ddimer, and lymphocyte percentages than control while there was a non-significant change for platelets
and absolute lymphocyte counts among studies groups. All studied laboratory biomarkers were higher in
non-survivors than in survivor COVID-19 groups. A significant correlation was found between D-dimer and
other laboratory biomarkers. Conclusion: Gender, ABO, and Rh were not associated but age and
comorbidities were associated with the severity of COVID-19. All studied laboratory biomarkers were
associated with mortality. |
| format | Article |
| id | doaj-art-f766ea21f01d4832bf19b7635a79758f |
| institution | DOAJ |
| issn | 2707-7799 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Erbil Polytechnic University |
| record_format | Article |
| series | Polytechnic Journal |
| spelling | doaj-art-f766ea21f01d4832bf19b7635a79758f2025-08-20T03:06:35ZengErbil Polytechnic UniversityPolytechnic Journal2707-77992023-09-011316573https://doi.org/10.59341/2707-7799.1746Clinical & Labor Clinical & Laboratory markers as pr ers as predictors for se ors for severity and erity and mortality in COVID-19Asma Ameen Ghareeb0Sazan Moffaq Abdulaziz1Department of Medical Laboratory Technology, Erbil Technical Health and Medical College, Erbil Polytechnic University, Erbil, IRAQ.Department of Medical Laboratory Technology, Erbil Technical Health and Medical College, Erbil Polytechnic University, Erbil, IRAQ.Backgrounds: COVID-19, a new health challenge, can be diagnosed by many laboratory biomarkers. Biomarkers became valuable for prognosis; identifying the severity and mortality of the disease in COVID-19 patients. This study aims to determine the association of clinical, demographics, and laboratory biomarkers (CRP, D-dimer, lymphocyte, and platelet) with the severity and mortality of COVID-19. Methods: Between June 1st and November 1st, 2020, 34 healthy controls and 104 COVID-19 cases were enrolled in this study. SARS-CoV-2 infection was confirmed using the real-time RT-PCR technique. All cases were analyzed for clinical, epidemiological, and laboratory biomarkers. COVID-19 cases were regrouped into mild (n=40), moderate (n=32), and severe (n=32) groups depending on the severity of the disease; it was also re-categorized into survivor (n=85) and non-survivor (n=19) groups depending on mortality. After collecting blood from participants, hematological parameters (lymphocyte and platelet) and other biomarkers (CRP and D-dimer) were measured by colter and Cobas c111, respectively. Results: For age categories and comorbidities, Statistical significance was found among COVID-19 groups. Regarding ABO, Rh, and gender, a non-significant difference was found among groups of COVID-19 patients. Cough and headache i the most common symptom in our population. SpO2 depressed more significantly in severe and moderate groups than in mild groups. Severe and moderate groups exhibit higher CRP, Ddimer, and lymphocyte percentages than control while there was a non-significant change for platelets and absolute lymphocyte counts among studies groups. All studied laboratory biomarkers were higher in non-survivors than in survivor COVID-19 groups. A significant correlation was found between D-dimer and other laboratory biomarkers. Conclusion: Gender, ABO, and Rh were not associated but age and comorbidities were associated with the severity of COVID-19. All studied laboratory biomarkers were associated with mortality. https://polytechnic-journal.epu.edu.iq/home/vol13/iss1/20covid-19,mortality,laboratory biomarkers,sars-cov-2. |
| spellingShingle | Asma Ameen Ghareeb Sazan Moffaq Abdulaziz Clinical & Labor Clinical & Laboratory markers as pr ers as predictors for se ors for severity and erity and mortality in COVID-19 Polytechnic Journal covid-19, mortality, laboratory biomarkers, sars-cov-2. |
| title | Clinical & Labor Clinical & Laboratory markers as pr ers as predictors for se ors for severity and erity and mortality in COVID-19 |
| title_full | Clinical & Labor Clinical & Laboratory markers as pr ers as predictors for se ors for severity and erity and mortality in COVID-19 |
| title_fullStr | Clinical & Labor Clinical & Laboratory markers as pr ers as predictors for se ors for severity and erity and mortality in COVID-19 |
| title_full_unstemmed | Clinical & Labor Clinical & Laboratory markers as pr ers as predictors for se ors for severity and erity and mortality in COVID-19 |
| title_short | Clinical & Labor Clinical & Laboratory markers as pr ers as predictors for se ors for severity and erity and mortality in COVID-19 |
| title_sort | clinical labor clinical laboratory markers as pr ers as predictors for se ors for severity and erity and mortality in covid 19 |
| topic | covid-19, mortality, laboratory biomarkers, sars-cov-2. |
| url | https://polytechnic-journal.epu.edu.iq/home/vol13/iss1/20 |
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