Clinical & Labor Clinical & Laboratory markers as pr ers as predictors for se ors for severity and erity and mortality in COVID-19
Backgrounds: COVID-19, a new health challenge, can be diagnosed by many laboratory biomarkers. Biomarkers became valuable for prognosis; identifying the severity and mortality of the disease in COVID-19 patients. This study aims to determine the association of clinical, demographics, and laboratory...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Erbil Polytechnic University
2023-09-01
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| Series: | Polytechnic Journal |
| Subjects: | |
| Online Access: | https://polytechnic-journal.epu.edu.iq/home/vol13/iss1/20 |
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| Summary: | Backgrounds: COVID-19, a new health challenge, can be diagnosed by many laboratory biomarkers.
Biomarkers became valuable for prognosis; identifying the severity and mortality of the disease in
COVID-19 patients. This study aims to determine the association of clinical, demographics, and laboratory
biomarkers (CRP, D-dimer, lymphocyte, and platelet) with the severity and mortality of COVID-19. Methods:
Between June 1st and November 1st, 2020, 34 healthy controls and 104 COVID-19 cases were enrolled in
this study. SARS-CoV-2 infection was confirmed using the real-time RT-PCR technique. All cases were
analyzed for clinical, epidemiological, and laboratory biomarkers. COVID-19 cases were regrouped into
mild (n=40), moderate (n=32), and severe (n=32) groups depending on the severity of the disease; it was
also re-categorized into survivor (n=85) and non-survivor (n=19) groups depending on mortality. After
collecting blood from participants, hematological parameters (lymphocyte and platelet) and other
biomarkers (CRP and D-dimer) were measured by colter and Cobas c111, respectively. Results: For age
categories and comorbidities, Statistical significance was found among COVID-19 groups. Regarding
ABO, Rh, and gender, a non-significant difference was found among groups of COVID-19 patients. Cough
and headache i the most common symptom in our population. SpO2 depressed more significantly in
severe and moderate groups than in mild groups. Severe and moderate groups exhibit higher CRP, Ddimer, and lymphocyte percentages than control while there was a non-significant change for platelets
and absolute lymphocyte counts among studies groups. All studied laboratory biomarkers were higher in
non-survivors than in survivor COVID-19 groups. A significant correlation was found between D-dimer and
other laboratory biomarkers. Conclusion: Gender, ABO, and Rh were not associated but age and
comorbidities were associated with the severity of COVID-19. All studied laboratory biomarkers were
associated with mortality. |
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| ISSN: | 2707-7799 |