Growth Arrest-specific 1 Inhibits Keap1/Nrf2 Signaling Transduction in the Activation of the Ferroptosis Program in Retinal Müller Cells

Growth Arrest-specific 1 Inhibits Keap1/Nrf2 Signaling Transduction in the Activation of the Ferroptosis Program in Retinal Müller Cells

Background: Diabetes retinopathy (DR) represents a microvascular disease in diabetes. Growth arrest-specific 1 (GAS1) is differentially expressed in rat retinal Müller cells under high glucose (HG) conditions, and its promotion of ferroptosis contributes to retinal cell death. How...

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Bibliographic Details
Main Authors: Rongfeng Dai, Yu Qian, Siqi Liu, Xi Zou, Shanshan Sun, Zhuo Sun
Format: Article
Language:English
Published: IMR Press 2025-03-01
Series:Frontiers in Bioscience-Landmark
Subjects:
diabetes retinopathy
gas1
keap1/nrf2
ferroptosis
müller cells
Online Access:https://www.imrpress.com/journal/FBL/30/3/10.31083/FBL27954
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